Bisoprosol and clopidegril: Just came... - British Heart Fou...

British Heart Foundation

50,149 members31,649 posts

Bisoprosol and clopidegril

Pauline762 profile image
17 Replies

Just came off bisoprosol and clopidigrel. It’s about 2 weeks now. I feel so weak and tired. Is this normal?

Written by
Pauline762 profile image
Pauline762
To view profiles and participate in discussions please or .
17 Replies

I think you probably need to give us a bit more background if you are expecting many replies? What sort of problems do you have, what meds, why and how you came off them, and so on? It will help with further posts if you filled in your profile.

in reply to

Hi,Are you on any other medication? Just wondering why you have come off bisoprolol and clopidogrel? I am on both these tablets, amongst others, the bisoprolol is to gently lower your heart rate and blood pressure, and the clopidogrel helps to stop clots forming. They are both very important medications and I am on them for life, so im wondering if this is doctor's orders? are they not suiting you? perhaps if you told us a wee bit more if you can, then we might know how to support you, even though we cant give medical advice

Pauline762 profile image
Pauline762 in reply to

I had stents fitted April 20. Cardiologist said I was only supposed to be on them a year, so stopped them recently. Still on 2 blood pressure tabs. Canderstan and co-tenidone as well as a statin and aspirin

in reply to Pauline762

Hi Pauline,I guess all medical professionals are different. Both my gp and cardiologist have said I will be on these tablets for life to prevent another heart attack!? Is there a reason you were only to be on these tablets for a year???

in reply to Pauline762

Hi Pauline did you have a HA? If not then he might have taken you off the Beta Blocker if your heart is in good condition, especially if you are trying to build up your strength through regular exercise. You would have come off the Clopidogrel the same as most people do, but in answer to your original question I don't think coming off either of these two meds would make you feel tired and weak, unless your heart is currently under stress as a result of the increased heart rate coming of the bisoprolol would cause. Do you exercise regularly this can be extremely beneficial ?

Pauline762 profile image
Pauline762 in reply to

I do normally exercise but hurt my knee a few weeks ago. Going back to the gym today. I developed unstable angina. Really unstable. Couldn’t even take 2 steps without pulse climbing to 140/159 and oxygen dropping as low as 58%!!! Had to stay in the hospital bed until stents fitted. They tried to stabilise me but nothing worked but I’m sure they said my heart wasn’t damaged. 1 artery was blocked by 90% and the other 75%. The cardiologist said I was very, very lucky

in reply to Pauline762

Yeah join the club! My LAD was almost blocked totally in 2 places. I knew a guy who sadly died while out on his bike, his wife told me that the autopsy revealed almost the same in him, poor devil was only 57. Did you have an echocardiogram? This would give a decent idea of what shape your heart is in, you are probably oneof the lucky ones like me who have come out of things without any lasting damage, although obviously we still have heart disease and always will, hence the need for good diet and exercise regimes, as I am sure you are aware. If your knee is giving you gyp you could try swimming? I used to hate it but have really got into it lately and trust me it is great for both helping injuries to heal and also for all round fitness, plus the weather is always the same. Once you get back into the swing of it you will start to feel better, I presume you don't have any Angina symptoms now? I always take the GTN with me just in case.

in reply to

Hi Doora. not sure why there is a touch of sarcasm in your reply I am not the originator of this post, the member profile is there for a reason and I think you will find mine is as detailed as any. Anyway, to answer your questions - I was on Clopidogrel and aspirin as a "dual" anti platelet medication, as most people are especially if you have the drug-eluting stents like me. After a year when the possibility of clots forming in the stents has gone (some thoughts are it should be less than a year) then it is usual to come off one of them and to remain on the other for life, hence I came off the Aspirin as per Cardiologists recommendation. I have since swapped back and forth between the two as both give me side effects, I am currently back on Clopi after being on Aspirin for the last couple of years. As for the Bisoprolol, this was making exercising very difficult for me, and my GP was happy to take me off both this and Ramipril as my heart is undamaged (no HA) and I wish to exercise to the highest possible levels in order to strengthen it as much as I can. I never had a history of high blood pressure and was put on these two as part of the "blanket" prescription that is used as a "cover all bases" solution on discharge from hospital. Not everyone who is prescribed Beta Blockers actually needs to be, the cardiologists tend to take the view most people are going to go home and sit in front of the TV for the rest of their days, however they have a tough job and not enough time to provide subjective fine tuning.

in reply to

Hi Lateguitarist,

I am so sorry you feel there was a touch of sarcasm in my reply. It was genuinely not my intention so please forgive me if I upset you in any way. I will put it down to clumsy use of language on my part. You are right when you say that when you have a heart attack you are given the standard life saving drugs to include clopidogrel, bisoprolol, aspirin and some sort of statin, in my case atorvastatin. My understanding is that this is then reviewed regularly and decisions are made whether you need to stay on all of them or if any can be stopped? I think that's right? In my case, I have to stay on all of them!! I guess im lucky as ive had no side effects from any of them appart from the statin which was originally 80mg per day and it made me really unwell so they reduced it to 40mg and im now fine. We are all different and have been in different situations with our hearts so im guessing medication is tailored to us as individuals and to the condition we had and now have?

Good luck with getting back to the level of fitness you want to be at and I wish you all the good luck with your medication. It can be hit or miss getting it all right cant it. Just all takes time.

in reply to

Hi Doora. Don't worry about it I was probably being oversensitive. I know from the horses mouth that most cardiologists have a "standard" prescription that is given to all "run of the mill" patients, which always seems to include a beta blocker and blood pressure med. Unfortunately your perception of being reviewed regularly seems to vary from place to place but in my case it is non existent, I have to push for everything, even regular blood tests. Yes you will need to stay on a blood thinner for life, and usually a statin, which I personally think are both very beneficial. However as regards the others I firmly believe that in a lot of cases we can work on our fitness and diet, and in my case I have done this and come off them with the agreement of my GP. It can be hit and miss, I seem to have problems with both types of blood thinner but have settled on Clopidogrel as the lesser of two evils, as apparently there is no alternative. It does take time yes, the mental side of things can be very difficult, which is another reason to have something to focus on like exercise and watching what we eat. Thanks for the good luck, you too!

Reiver5 profile image
Reiver5 in reply to

Good reply...

Pauline762 profile image
Pauline762

I was told by the cardiologist, the statutory requirement was one year but it’s like I’ve turned into an old granny since I’ve stopped. Sleeping all time. So tired!!!

Clopidogrel caused me a lot of problems and I suffered with it for 6 months until I took myself off it. I had tried ticagrelor but that was even worse.

I felt it was 6-7 weeks before the side effects of the clopidogrel started to subside after cessation.

This is just my experience. I'd recommend trying to speak to your GP or cardiologist to see what they think.

in reply to

What problems did it give you? I find it gives me a burning sensation in my arms, not too bad but I would sooner it didn't.

in reply to

Similar. Burning in hands, feet and back of arms (although a lot of meds do that to me). I also went from being regular to very constipated, which created its own set of problems.

in reply to

I have had an un-diagnosed problem with a tingling/burning sensation in my hands, and mainly forearms ever since I had stents and went on medication. The blood thinners are the only possible culprit, unless by body has changed somehow. It has been almost 3 years now and it has never got any worse, comes and goes. Aspirin does it to a lesser extent but gives me gastro-intestinal problems. I would imagine it is your choice of diet that is causing the other problems.

in reply to

I think I have a mast cell problem which means my body frequently has histamine levels that are too high. This can lead to nerve pain. Since I've been on aspirin (which is a histamine liberator), this problem seems to be triggered far more easily. If I avoid high histamine and histamine triggering foods (which is difficult), things seem to improve. I also have to avoid triggers, local anaesthetic and fluorescein I have found cause huge problems.