Hi, I was prescribed Bisoprolol after an overnight visit at AE, i had to stop this. because side effects, one being giving high pulse, opposite it was supposed to do. My GP put me on Digoxin 125, back last week, but my pulse was 90, so up the dose to 250. Since then I don't feel well, no appetite, lethargy, and lost weight, I am drinking water so I am hydrated. Is this a blip, or will it pass. I am not overweight , so quite concerned ,don't want to lose too much weight, but always have nauseous so it's a vicious circle. Does anybody have this with Digoxin. I have been on Warfarin for 7years after having a mini stroke, but have a good range of 2.5 INR .