Ebastine blocks Histone methyltransferase

[Watcher24]

Has anybody tried this on combination with an ARSi?

pmc.ncbi.nlm.nih.gov/articl...

[MelodyCat]

I have not tried it. I have been reading in vitro and mouse model research for years. Most in vitro stuff should be looked st with great caution since it does not take into account your body’s metabolism which can change things dramatically. In vivo is better since it now takes into account metabolism, albeit a mouse, but often is short term (often only 28 days) and special types of mice. Additionally, they never make note of the extraordinary dosages used. The normal dose for ebastine is 10mg. They gave the mice 10mg per kilogram. A 170 lb. M is about 70 kg indicating a 70x normal dose. Seems like a red flag since who knows what other effects a megadose would have. I would recommend getting a copy of “Cancer Care” by Paul Marik if you are interested in adjunct care. It isn’t perfect but it is research based and doesn’t recommend silly things like taking baking soda or gasoline! Good luck!

[GP24]

Mevrometostat by Pfizer adresses EZH2 and extends the effectiveness of Enzalutamide in CRPC. urotoday.com/video-lectures...

[j-o-h-n]

When searching the H.U. history file I came across a few posts which contained the word Ebastine. (Not many hits).

3 regarding APC, 2 regarding IBS, 2 Regarding Lung and 1 or 2 other miscellaneous ones.

Good Luck, Good Health and Good Humor.

j-o-h-n