nadir

[1Warrior1]

when it the right time to monitor for this. My oncologist has never spoken about it

[Tall_Allen]

It depends on your diagnosis and treatment. There's nothing in your profile, so no one can answer.

[1Warrior1 in reply to Tall_Allen]

my profile shows pt3bn1mo

I’m currently on Eligard and Zytiga.

Psa <.006 for a while.

Had RP and 40 rounds

Of IMRT as well

[Tall_Allen in reply to 1Warrior1]

Nadir is not used post-prostatectomy, only after primary radiation. Ideally, your PSA should be undetectable.

[tango65]

Discuss having 3 years of ADT with 2 years of Zytiga.

If everything works well and there were not distant mets the PSA should not increase when your testosterone recovers after stopping the 3 years of ADT.

[1Warrior1 in reply to tango65]

wow

That’s exactly my treatment plan.

Just don’t understand nadir.

[tango65 in reply to 1Warrior1]

After radiation therapy as primary treatment of localized PC the nadir is determined when the testosterone recovers after finishing the ADT usually given with the radiation.

Testosterone will increase and the PSA will increase since the prostate is still present. The PSA eventually will stabilize. This value is considered the nadir.

If there is not cancer left in the body this value will remain stable or oscillate.

If the PSA increases more than 2 points over the nadir it is considered a BCR in the absence of a prostate infection.

Your situation is different, since you had a radical prostatectomy. If all the cancer was destroyed with the RP and the radiation your PSA nadir, having normal testosterone values should be undetectable since you do not have a prostate.

[PSAed in reply to tango65]

Thank you for such a detailed and informative explanation. Much appreciated.

Copied and Filed!

[j-o-h-n]

Don't fear your nadir will appear...........

j-o-h-n <===<<< Senior management is about to spike my spikes....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 04/22/2023 11:42 PM DST