LuPSMA prognostic model

[lokibear0803]

Apologies if this has already been posted.

The link below is for a nomogram, something developed after VISION — input a few variable quantities and get prediction around response to Lu-177. It’s intended to assist (vs dictate) MO decisions around treating with that therapy or not.

SUV-mean might be the trickiest variable to figure out since not all scan reports give a number for this (it takes more sophisticated software vs just calculating SUV-max). I just guesstimated mine.

Be sure to read the disclaimer before you use this, and then the PDF report after you get the prediction.

uclahealth.org/medical-serv...

[Ramp7]

Interesting, I was in a trial study so lots of information is not shared. I have no idea my SUV score. I was told my PSMA expression was over 95 %. But alas after 6 infusions the PSA started climbing again. So very good initial results but not long lasting. Doing BAT self administered and responding nicely.

[lokibear0803 in reply to Ramp7]

This article discusses nonresponders, how that is a pressing problem with radio ligand therapy.

urotoday.com/conference-hig...

It’s worth a read.

[Ramp7 in reply to lokibear0803]

Thank you.

[lokibear0803 in reply to Ramp7]

Sorry to hear the LU didn’t work, but happy to hear the BAT is.

You might consider getting an FDG scan if you haven’t yet done that. There are other types of radioligand therapy that use markers other than PSMA, the gastrin-releasing peptide receptor (GRPR) comes to mind — targeted by a copper isotope iirc.

But stick with the BAT for now if it’s working. I wish you the best of luck.

[Ramp7 in reply to lokibear0803]

Thanks for the encouragement. I have 3 MO's and a Urologist assisting me on BAT. They cannot commit to it but are fascinated and are monitoring my progress carefully. Although completely done by me.

Reading the article I sense where my soft spot is. I have one lymph node and one bone metastasis. Looks like a difficult combination for a durable response.

[lokibear0803]

BAT to the rescue. My tumor has an SPOP mutation, and there’s research that this makes me a non-responder to BAT. We’re dealing with a heterogeneous disease.

[j-o-h-n]

Thanks Loki and that's no Joki.....

(Beware the ides of March).

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 03/15/ 2023 10:58 PM DST