BAT and PD-L1 inhibitor

The BAT researchers have noted some exceptional responses in patients using Pembro after BAT - so far the phrase priming has been used. Now they seem to know why, PD-L1 is upregulated in EnzaResistant cell lines during BAT theraphy.

nature.com/articles/s41419-...

Maybe a combo of BAT and PD-L1 like Pembro or Dostarlimab will be efficient .

[Hidden]

For US living outside US, my MD accepts BAT treatment but insist on using testoteron cypionate used in clinical trials or by patients on BAT treatment. Which producer or Brand do you use?

[lokibear0803]

From the article, quite possibly one of the best sentences ever written:

Mechanism dissection indicates that transactivated AR can increase circularRNA-FKBP5 (circFKBP5) expression, which could sponge/inhibit miR-513a-5p that suppresses the PD-L1 expression via direct binding to its 3ʹUTR to negatively impact immune surveillance from NK cells.

This is why I stick to physics and math.

[Hidden in reply to lokibear0803]

Agree 100%, on the other hand this is important for those considering BAT being Enza resistant.