Mediterranean-style Dietary Pattern Improves Fatigue and Quality of Life in Men with PCa on ADT.

[pjoshea13]

New Australian study below [1].

"Cancer-related fatigue (CRF) is a prevalent and persistent symptom from androgen deprivation therapy (ADT) in prostate cancer. The Mediterranean-style dietary pattern (MED-diet) offers a plausible mechanism to mitigate CRF through reducing inflammation and improving body composition. This study aimed to evaluate the effects of a 12-week MED-diet, compared to usual care, on CRF and quality of life in men with prostate cancer treated with ADT."

"The MED-diet improved {cancer-related fatigue} at 8-weeks ... and 12-weeks, quality of life ... at 12-weeks .., reduced total body mass at 8-weeks ... and 12-weeks, lean mass at 8-weeks .., and IL-8 at 8-weeks ... compared to usual care. The MED-diet demonstrated zero adverse events ...."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/325...

Clin Nutr

. 2020 May 25;S0261-5614(20)30250-8. doi: 10.1016/j.clnu.2020.05.016. Online ahead of print.

Mediterranean-style Dietary Pattern Improves Cancer-Related Fatigue and Quality of Life in Men With Prostate Cancer Treated With Androgen Deprivation Therapy: A Pilot Randomised Control Trial

Brenton J Baguley 1 , Tina L Skinner 2 , David G Jenkins 3 , Olivia R L Wright 4

Affiliations collapse

Affiliations

1 Institute of Physical Activity and Nutrition, Deakin University, Geelong, Australia; School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia. Electronic address: [e-mail].

2 School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.

3 School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD, Australia.

4 School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.

PMID: 32534948 DOI: 10.1016/j.clnu.2020.05.016

Abstract

Background & aims: Cancer-related fatigue (CRF) is a prevalent and persistent symptom from androgen deprivation therapy (ADT) in prostate cancer. The Mediterranean-style dietary pattern (MED-diet) offers a plausible mechanism to mitigate CRF through reducing inflammation and improving body composition. This study aimed to evaluate the effects of a 12-week MED-diet, compared to usual care, on CRF and quality of life in men with prostate cancer treated with ADT.

Methods: Twenty-three men (65.9 ± 7.8 years; body mass index: 29.6 ± 2.7 kg/m2; ADT duration: 33.8 ± 35.6 months) receiving ADT for ≥3 months were randomly assigned (1:1) to 12-weeks of usual care or the MED-diet involving six individualised nutrition consults. Primary outcomes included CRF [Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale (FACIT-F) and quality of life [FACIT-General (FACIT-G)], secondary outcomes included body mass/composition and interleukin (IL)-6 and IL-8 concentrations measured at baseline, 8-weeks and 12 weeks. Intervention feasibility was measured by intervention safety, study completion rate, consult attendance, and adherence to the MED-diet through the Mediterranean-diet adherence screener (MEDAS). Intention to treat linear mixed models were used to determine changes in outcomes between the MED-diet and usual care at baseline, 8-weeks and 12-weeks.

Results: The MED-diet improved CRF (FACIT-F) at 8-weeks [+4.8 (0.0, 9.8); P = 0.05] and 12-weeks [+7.2 (2.2, 12.0); P = 0.005], quality of life (FACIT-G) at 12-weeks [+9.2 (2.7, 15.8); P = 0.006], reduced total body mass at 8-weeks [-2.51 kg (-4.25, -0.78); P = 0.005] and 12-weeks [-2.97 kg (-4.71, -1.25); P = 0.001], lean mass at 8-weeks [-1.50 kg (-2.91, -0.10); P = 0.036], and IL-8 at 8-weeks [-0.18 ng/ml (-0.34, -0.02); P = 0.029] compared to usual care. The MED-diet demonstrated zero adverse events, 91% study completion, 100% attendance, and 81% adherence to the MEDAS.

Conclusion: The MED-diet is safe and feasible, and has the potential to improve CRF and quality of life in overweight men treated with ADT compared to usual care. Further exploration of the MED-diet is warranted in a larger powered sample size to consolidate these findings.

Keywords: Cancer survivors; Diet intervention; Nutrition; Prostate cancer.

Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.

[Hidden]

I'm doing an N of 1 experiment on myself to see what diets work best for me (if they even make a difference). I'm using PSA as a proxy. Keto, plant based high carb, mediterranean. Right now I'm trying Keto.

[Cleodman in reply to Hidden]

I have also tried keto for 1 year, vegan, Mediterranean, vegetarian and no restrictions. All for at least 6 months consecutively. I didn’t see any correlation to feeling better or better control of PSA rise or radiographic evidence of progression of disease in my case. I do think diet is important especially in men who are obese (as the study posted points out) or those who eat a high inflammatory diet (red meats, etc) but I have always eaten well and I assume healthy and my BMI is 22 so I don’t really get too much benefit in regards to fatigue. I have opted for a plant based diet going forward.

[Hidden in reply to Cleodman]

Good data. Thanks. My ideal diet for my tastes would be lots of olive oil, salmon, turmeric cauliflower rice, peanut butter, berries and other fruit, some veggies and brown rice. Healthy but I've always eaten healthy. Diet would be kind of a amalgamation of keto, plant based, and mediterranean.

[pjoshea13 in reply to Hidden]

Peanut butter? See:

healthunlocked.com/advanced....

-Patrick

[LearnAll]

Thanks Patrick...Its common sense that good diet and right nutrition helps with immune system and cancer fighting capability in good shape.

But...sadly..many people are so devoid of common sense and do not want people to know this very basic scientific fact.

[GoBucks]

Hummus for the win!!

[Hidden]

I read some other NIH studies that indicate nuts are good for PCa. And some inconclusive ones. So, good? Bad? Mediocre? A non issue? Bottom line I like peanut butter and don't do the sugar added, salt added, chemical junk. Organic peanuts only. Nothing else.

[Dino24 in reply to Hidden]

Did the study specify peanuts which actually are not nuts but legumes?

[Hidden in reply to Dino24]

hifuprostateservices.com/20....

I also found some mayo and harvard health mentions of peanuts being healthy for the prostate. Nothing that really sticks out at me though like "this is a cure" or "this will kill you"

[olloreda]

Did they explain which "mediterranean diet" was?

[pjoshea13 in reply to olloreda]

They used the 14-point Mediterranean Diet Adherence Screener (MEDAS) used in the Prevención con Dieta Mediterránea (PREDIMED).

academic.oup.com/jn/article...

-Patrick

[Wings-of-Eagles]

Thanks Patrick,

I will definitely try it. I have procrastinated long enough, I am 25 pounds overweight, and feel the need to loose weight ,eat healthier and get some energy back. I have been feeling more fatigue every day with PCa.

Wings aka Dan in So Cal

[pjoshea13 in reply to Wings-of-Eagles]

Hi Dan,

Here is Dr. Myers' take:

askdrmyers.wordpress.com/20...

-Patrick

[Wings-of-Eagles in reply to pjoshea13]

Thank you very much you are always supplying us with great information I appreciate it

[Hidden in reply to pjoshea13]

Thanks. If keto doesn't work I think I'll try Mediterranean next and likely stay on it for a while.

[j-o-h-n]

Right up my alley.... Remember I'm Greek..... OPA!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 06/16/2020 6:35 PM DST

[pjoshea13 in reply to j-o-h-n]

What part of Greece? They say that the Cretan diet leads to long life. But does it include ice cream? -Patrick

[j-o-h-n in reply to pjoshea13]

Crete, the Island, My family is from the northern mountainous part called Epirus (just below Albania)..... and ice cream is called Pagato... which means frozen/cold..... How about feta ice cream? Yucks.... OPA!

BTW have you ever visited Greece?

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/17/2020 1:28 PM DST

[pjoshea13 in reply to j-o-h-n]

My wife & I talked about getting away to a Greek island with good seafood restaurants, etc. We spoke of Crete a number of times, but we haven't travelled since diagnosis 16 years ago. -Patrick

[j-o-h-n in reply to pjoshea13]

Well you have to make the trip....Try the island of Rhodes.... OPA!

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/18/2020 6:24 PM DST