Lu177PSMA

[JanJames]

Hi

Does anyone know which brand of Lu177 they use in Munich?

thanks

Jan

[Tall_Allen]

They were trying Lu-177-PSMA-I&T at the Technical University of Munich in clinical trials. I don't know if they switched from Lu-177-PSMA-617 on their standard protocol.

[JanJames in reply to Tall_Allen]

Thank you so much

[Tall_Allen in reply to JanJames]

Why do you ask?

[tango65]

They use Lu-177 PSMA I&T at the Technical University of Munich. The Wolfgang Maximilian University uses the Lu 177 PSMA 617. The I&T ligand is a smaller molecule than the 617 ligand and have the theoretical advantage of getting inside the cancer cells more frequently or in a larger proportion of the administered dose than the 617 ligand.

[JanJames in reply to tango65]

Thank you so much , very helpful

[Stegosaurus37 in reply to tango65]

This is great info. I'm going for a participation interview for a Lu-177 trial next week and you've given me a great question. Thank you!!

[The_Don5 in reply to tango65]

are there any clinical trials to back this up?

[tango65 in reply to The_Don5]

I do not know of any clinical trial comparing Lu 177 PSMA vs Lu 177 PSMA 617 . As I said the Lu 177 PSMA IT has a theoretical advantage.

[The_Don5 in reply to tango65]

How did it work for you?

[tango65 in reply to The_Don5]

Very well. I had a large number of lymph nodes metastases in the pelvis and abdomen up to the renal arteries. One treatment took care of all the metastases. The result of the treatment has been confirmed by 2 Ga 68 PSMA PET/CT done 5 weeks and 2 years after the treatment.

[The_Don5 in reply to tango65]

That's absolutely fantastic, V pleased for you- another success story. We were considering TUM and still could its just we didn't recognise the ligand I&T , everyone talks about the 617 but I guess if its more effective that's even better. Are there any links on its properties you could post?

[tango65 in reply to The_Don5]

There is some info here:

ascopubs.org/doi/abs/10.120...

thno.org/v05p1388.htm

ncbi.nlm.nih.gov/pubmed?ter...

Lu 177 DOTAGA is the same than LU 177 IT.