New Korean cell study.
Posted without much enthusiasm, since this is the only PCa study. Barley grass extract is mostly available as part of a blended product, but here is a "Just Barley" product:
iherb.com/pr/Pure-Planet-Or...
Anybody here use it?
Barley grass extract "inhibited the viabilities of breast and prostate cancer cells", & "caused apoptosis" (cell death).
As with almost every phytochemical PCa study, the effect was due to generation of ROS (reactive oxygen species). The effect was blocked by NAC (N-acetyl-L-cystein). NAC should not be used with high-dose polyphenols.
Unusual for the Abstract not to mention the PCa cell lines used.
-Patrick
ncbi.nlm.nih.gov/pubmed/?te...
Biomed Rep. 2017 Jun;6(6):681-685. doi: 10.3892/br.2017.897. Epub 2017 May 3.
Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production.
Woo SM1, Kwon SC2, Ko SG1, Cho SG3.
Author information
Abstract
Cancer remains a leading cause of mortality worldwide, therefore food products are being investigated for potential prevention or treatment strategies. The ingredient, barley grass extract (Hordeum vulgare L.; Bex) is used to prevent or ameliorate various types of disease. In cancer, Bex has been revealed to inhibit tumor growth. However, its effect on cancer cells is yet to be clearly defined. In the present study, the effect of Bex on cancer cell growth was investigated. Bex inhibited the viabilities of breast and prostate cancer cells according to the results of MTT assays. Accordingly, Bex caused apoptosis, which was confirmed by Annexin V staining and western blot analysis for poly (ADP-ribose) polymerase and caspases. Furthermore, Bex increased the intracellular levels of reactive oxygen species (ROS), and N-acetyl-L-cystein blocked Bex-induced apoptosis. Therefore, the study demonstrated that Bex causes apoptosis of breast and prostate cancer cells by increasing intracellular ROS levels.
KEYWORDS:
barley grass extract; cancer; reactive oxygen species
PMID: 28584641 PMCID: PMC5449973 DOI: 10.3892/br.2017.897