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đź“š Research 101: Who can take part in a clinical trial?
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
AnnaHU
HealthUnlocked
in
Research Opportunities
1 year ago
The immune system doesn't know that your eye's exist - Ocular immune privilege
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948372/#:~:text=The%20eye%20has%20a%20special,were%20not%20rejected%20%5B1%5D. The eye has a special relationship with the immune system, known as immune privilege. The term was coined in the 1940s by Sir Peter Medawar, who noticed that foreign tissue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948372/#:~:text=The%20eye%20has%20a%20special,were%20not%20rejected%20%5B1%5D. The eye has a special relationship with the immune system, known as immune privilege. The term was coined in the 1940s by Sir Peter Medawar, who noticed that foreign tissue
zaax
in
CLL Support
2 years ago
Focal Ablation doesn't work (again)
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Tall_Allen
in
Prostate Cancer Network
1 year ago
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Ambroxol
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Badmouth
in
Cure Parkinson's
1 year ago
Any advice about future treatment?
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Riverflo
in
My Ovacome
1 year ago
To those who replied to my question on clinical trials
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
MyMiracle13
in
SHARE Metastatic Breast Cancer
1 year ago
Self Hate
Anyone else have a lot of self-hatred? What are you doing to cope or conquer these feelings? I feel like the "hole" I am in is getting deeper and deeper - and worried that I might actually get the courage to do something stupid.
Anyone else have a lot of self-hatred? What are you doing to cope or conquer these feelings? I feel like the "hole" I am in is getting deeper and deeper - and worried that I might actually get the courage to do something stupid.
Tough-Fry
in
Anxiety and Depression Support
2 years ago
MPR flare-up or Aclasta reaction?
Went off prednisone early in July 2022. Was fine till 10 days ago. Started with pain in my legs and with 5 days spread through my whole body - same as I had when I was diagnosed with PMR in March 2020. Because of a low bone density scan the specialist physician recommended Aclasta infusion that was done
Went off prednisone early in July 2022. Was fine till 10 days ago. Started with pain in my legs and with 5 days spread through my whole body - same as I had when I was diagnosed with PMR in March 2020. Because of a low bone density scan the specialist physician recommended Aclasta infusion that was done
DeWet
in
PMRGCAuk
2 years ago
Tired pf existing like this
I used to be a hopeful person. I could believe that things were going to work out even when I couldn't see how...but this year I feel like my hope died. A large project I've been working on failed (or it feels like it failed) and I don't feel like I have a purpose anymore. I have anxiety attacks daily
I used to be a hopeful person. I could believe that things were going to work out even when I couldn't see how...but this year I feel like my hope died. A large project I've been working on failed (or it feels like it failed) and I don't feel like I have a purpose anymore. I have anxiety attacks daily
Milkshake_15
in
Anxiety and Depression Support
2 years ago
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Bolt_Upright
in
Cure Parkinson's
1 year ago
IVIG after heart surgery and stopping IBRUTIMIB
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
misterbee
in
CLL Support
1 year ago
Don’t know what to do
I have so much going on in my life I have no idea on what to do or where to go. A year ago my husband decided he wanted to bring in another women into our marriage he put our relationship on the back burner and has focuse all his energy and time on their relationship. He has gotten this women pregnant
I have so much going on in my life I have no idea on what to do or where to go. A year ago my husband decided he wanted to bring in another women into our marriage he put our relationship on the back burner and has focuse all his energy and time on their relationship. He has gotten this women pregnant
Dolphfan47
in
Anxiety and Depression Support
2 years ago
Volunteer Opportunity - Prostate Cancer Patient Advocate with SWOG for Genitourinary Cancer Committee
I have served as a volunteer Patient Advocate representing the LGBTQ+ Community with the Southwest Oncology Group (SWOG) for the past two years. As such I am serving as a member of the Patient Advocacy Committee (PAC) and the Diversity, Equality, and Inclusion Committee. I attend monthly zoom meetings
I have served as a volunteer Patient Advocate representing the LGBTQ+ Community with the Southwest Oncology Group (SWOG) for the past two years. As such I am serving as a member of the Patient Advocacy Committee (PAC) and the Diversity, Equality, and Inclusion Committee. I attend monthly zoom meetings
JRPnSD
in
Advanced Prostate Cancer
1 year ago
HAS ANYONE PARTICIPATED IN CLINICAL TRIALS
Hello everyone. Has anybody on this forum ever joined in a clinical trial? I have been invited to join a Phase 1 clinical trial for LOXO-783. The new drug is for those who have the PIK3CA mutation. At first I was very excited to join but when I was looking at the screening requirements, I don’t
Hello everyone. Has anybody on this forum ever joined in a clinical trial? I have been invited to join a Phase 1 clinical trial for LOXO-783. The new drug is for those who have the PIK3CA mutation. At first I was very excited to join but when I was looking at the screening requirements, I don’t
MyMiracle13
in
SHARE Metastatic Breast Cancer
1 year ago
response to clinical trial application?
A couple of months ago, I applied for a clinical trial that had just started recruiting. They are still recruiting and have begun administering the trial drug to participants. I never heard from trial staff. Has anyone applied for a trial and received notice whether they were rejected? Thank you. Sashay
A couple of months ago, I applied for a clinical trial that had just started recruiting. They are still recruiting and have begun administering the trial drug to participants. I never heard from trial staff. Has anyone applied for a trial and received notice whether they were rejected? Thank you. Sashay
Sashay2020
in
My Ovacome
1 year ago
Calquence and mouth issues?
I’m wondering if anyone taking Calquence has experienced white patches in their mouth? My dentist noticed I have one on my tongue side of gums. It doesn’t hurt and can’t be scraped off (fits the description of leukoplakia when I Google). My dentist thought it looked like trauma and said to call if it
I’m wondering if anyone taking Calquence has experienced white patches in their mouth? My dentist noticed I have one on my tongue side of gums. It doesn’t hurt and can’t be scraped off (fits the description of leukoplakia when I Google). My dentist thought it looked like trauma and said to call if it
CoCoLuna11
in
CLL Support
2 years ago
Interesting video with active ongoing clinical trial. Maybe on option for some!!
https://www.urotoday.com/video-lectures/asco-2022/video/2853-the-future-of-radiopharmaceuticals-in-the-treatment-of-prostate-cancer-philip-kantoff.html
https://www.urotoday.com/video-lectures/asco-2022/video/2853-the-future-of-radiopharmaceuticals-in-the-treatment-of-prostate-cancer-philip-kantoff.html
Bkraus1
in
Advanced Prostate Cancer
1 year ago
More on the biomarker NFL
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 Â There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 Â There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
House2
in
Cure Parkinson's
1 year ago
Annovis Bio Announces Approval for EU Clinical Trial Sites for the Phase 3 Study of Buntanetap for the Treatment of Parkinson's Disease
This trial is already open in the United States, and I believe some on this forum are participating. This announcemment indicates that the company is also opening clinical trial sites across the EU. I checked clnicaltrials.gov but they have not listed the EU sites yet. https://www.prnewswire.com/news-releases
This trial is already open in the United States, and I believe some on this forum are participating. This announcemment indicates that the company is also opening clinical trial sites across the EU. I checked clnicaltrials.gov but they have not listed the EU sites yet. https://www.prnewswire.com/news-releases
Canddy
in
Cure Parkinson's
1 year ago
Neuron23 Announces First-in-Human Dose in Phase 1 Clinical Trial of its Best-in-Class Brain-Penetrant LRRK2 Inhibitor for Parkinsons Disease
NEU-723 has been shown in preclinical studies to have strong disease-modifying potential with a higher therapeutic index than other candidates in development https://www.prnewswire.com/news-releases/neuron23-announces-first-in-human-dose-in-phase-1-clinical-trial-of-its-best-in-class-brain-penetrant-lrrk2
NEU-723 has been shown in preclinical studies to have strong disease-modifying potential with a higher therapeutic index than other candidates in development https://www.prnewswire.com/news-releases/neuron23-announces-first-in-human-dose-in-phase-1-clinical-trial-of-its-best-in-class-brain-penetrant-lrrk2
Farooqji
in
Cure Parkinson's
1 year ago
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