Have you ever participated in a clini... - SHARE Ovarian Can...
Have you ever participated in a clinical trial? Why or why not? Tell us about it in the comments.
It was a dose dense trial of taxol, carboplatinum and avastin. Gave me three years of NED!!
I did the ICON8 trial to help to determine the kindest way to administer taxol & carbo
Currently in second line treatment. If I don't respond to this my GynOnc will look into what clinical trials I may be eligible for.
First let me say hats off to the ladies that have/will do them. My original deal with God and my Dr was to please let me be well enough to travel and take care of of my 1st grandson while my daughter was having my 2nd grandson and that was in December... So with their expertise I was able to do that with no complications. Now each and every day after that has been icing on the cake and and I plan to keep my word to both and not ask for any more miracles to used up on me. There are so many Mothers and wonderful ladies out there that need those resources of the wonderful doctors and trial medications that I don't have the heart to have them diverted my way. At this point of the journey if my cancer has spread even further than my liver at the next scan or rise in CA125 count, it will have been within the 6 months of 1st line treatment. I am truly blessed.
The first trial I did was to find out whether adding Avastin in to the usual carboplatin-paclitaxel chemo for frontline treatment after surgery would be worthwhile, and whether doing Avastin maintenance afterwards helped. There were 3 arms of the trial, all using Avastin along with chemo and for 22 cycles total; mine was IP carboplatin & dose-dense paclitaxel (which was what I'd wanted without the trial). It seemed to help me, but the overall results seem to show that adding Avastin in almost erases the increased PFS gotten by having IP chemo. I had a recurrence 28 months after finishing the carbo-taxol (Avastin doesn't count as "chemo").
The second trial I'm doing is to test out using olaparib as a maintenance chemo after recurrence for BRCA+ mutation carriers. I've been on olaparib or placebo for 28 months now, starting 4 weeks after finishing my carbo-Gemzar chemo for my recurrence. I have constant chemo fatigue but otherwise am doing well.
Have never needed to. But would be open to the possibility if needed.
Was on a monoclonal antibody trial - phase 2 and after phase 3, it was not approved. I have been in remission for 10 years to maybe it helped me (stage 3C)
Just recurred less than 6 months after front line. Clear cell. This is a Phase 2 trial for clear cell ladies (ovarian and womb) have recurred within 6 months. Not enough research etc done yet for clear cell so I'm happy to join this one.
Currently waiting to hear whether I will be having a tablet twice a day or weekly Taxol. Randomised so no choice. No placebo!
We need more specific treatments for our different types of Ovarian cancer
Trial is NiCCC
I could not stay on the trial due to the fact my creatinine levels were too high I was on it for 5 months
I was in an international clinical trial for Veliparib for about 20 months. It was a double blind study, but it quickly became obvious that I was on the trial drug. The side effects of the trial drug were worse than the side effects of my chemo drugs (carboplatin and Taxol). I had, and still have from time to time, uncontrollable shaking. I also had neuropathy in both my hands and my feet. It is all gone in my hands, and getting better in my feet. I had a lot of nausea, and complete exhaustion (in bed like 20 hours a day).
I loved the fact that I had only one nurse I interacted with, close monitoring--CTs and bloodwork every 12 weeks at the expense of the trial for the first year and I would be followed with CTs and bloodwork for 10 years. In addition, I felt like I was possibly helping some of my young friends who are now undergoing infertility treatments, thus raising their chances for ovarian cancer.
Likely won't be acceptable because I have two kinds of cancer at once.
