How long did it take people to begin se... - LDN Research Trust
How long did it take people to begin seeing benefits from LDN?
I take LDN for Hashimoto's, IBD, Pernicious Anemia, & Vitiligo. I began with a dosage of 1.5 mg at bedtime, and almost immediately noticed a difference in pain level. By the 3rd months, my TPO antibodies reduced from 899 to 104. I attempted to raise to 4.5 mg but my "sweet spot" seems to be at 3.0 mg. I usually take my LDN just prior to my head hitting the pillow (around 11 pm), and after initial difficulties sleeping (for about 10-days and again when I raised dosage), I now sleep like a baby, and feel great!
I experienced less fatigue/more stamina within a few weeks of starting LDN at 1.5 mg for RRMS.
Shortly followed by less brain fog and anxiety. The improvements continued as time went on and I increased my dose to 3.0mg.
After initial insomnia for several weeks, I now sleep more soundly.
The first 2 or 3 days of taking LDN resulted in my pain going into overdrive (I had been warned that this would happen by my prescribing Dr)...but I persevered, and it then subsided. Within a week the pain levels were fine-much below normal....I do still get some pain/tenderness. (I have Lupus), but I can cope with it, mostly without medication...if it gets a bit much I will take paracetamol or ibuprofen, but the times I have to take these are few and far between-prior to LDN I was popping pain tablets-all day, every day!!
Only two days on LDN for TMS Tumefactive Multiple Sclerosis I noticed all my brain fog lifting, l could finish off m own sentences again. After a year now I am happy.I look to the future instead of just living in the moment. LDN is amazin I shall be taking for the rest of my life Xxx
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I was one of the lucky ones and felt the results in 3 days. I have RRMS and the cognitive issues got better in 3 days. Then the balance, dizziness, bladder, and all the other symptoms improved. I started out at 3.0 mg, then 6 months later upped it to 4.5 mg and have been on 4.5 mg for going on 14 years now! I can say that LDN saved my quality of life. Sometimes I forget I even have MS, it's been that amazing for me. My Neuro is awed that I'm in such good shape for having this disease for 19 years now. I've never tried the mainstream MS drugs, I started on LDN 5 years after my first exacerbation and know I made the right decision. I recommend LDN highly; it saved me!
Man, I'd love to be able to take more than 2 mg. I have better QOL at 2 but would be an amazing person, like you, at 4.5. I think you're right. LDN saved you. I've never taken any of the mainstream MS drugs, either. I've had MS for 42 years and I'm still walking. Wrote a book: Muddling Through MS. Website: muddlingthroughms dot com.
Thank you Katemtms... I know a lot of people take less mg than I do and are doing extremely well. LDN is such a unique drug... dosages work so differently on all of us. Some people do better on a lower dose ... it depends on the disease and the chemistry of our bodies. I'm impressed that you have had MS for so many years and are doing so well. I'll check out your book... thank you for posting! 
I started 3 days ago on LDN.I have RRMS.Today I awoke to find one of my hands has been relieved of the numbness it had suffered for the past 2 years.
So glad for you. It's weird and wonderful to have symptoms go away when you least expect it.
Thanks alot. I've not slept very well for months and was really expecting that maybe it would let me sleep.However that didn't happen and instead I found the numbness had gone.Now I'm hoping it will eventually work on my other hand.
I've had MS for more than 40 years and I've been taking LDN for six years with mostly good results. I started at 1.5 and in two weeks went to 3 mg and felt young again!! I had energy, stamina, and great mood. That lasted 15 months and then I had a spasticity problem that I could not live with (urethra cramped and I couldn't pee!) The years since, I've tried this dose and that but have come to the conclusion that 2 mg is my dose. Four years ago, I went gluten free and eight months ago vegan. I also raised my vitamin d level to almost 100 (from a fragile 16). Put these all together and I'm feeling better than I have in a long, long time.
you write that you raised your vit d level to almost 100 - may I ask 100 what ?
Because I have gastritits, it took me a while to find something I could take. Capsules, gelcaps, liquid. My stomach crashed before I could get enough into me. FINALLY, a health food store recommended a chewable by KAL that I dissolve under my tongue. If you look on the Mayo Clinic website or google Mayo's vit d recommendations, you'll find one for your condition. For MS, they say 10K a day and that's what I take. I was taking 15 just in case I missed one here and there but the cardio (who was the one I thought might have a concern because d raises the calcification in your blood). He told me to stick to 10. It makes a world of difference!
what is the best dose for vit d to work properly? and where can I buy more than tiny doses of it.
Check the Mayo Clinic on line for dosing recommendations. You can get KAL vitamin d in a vitamin shop. I buy the 5K and take it twice a day. I don't buy the 10K. Maybe it's just me?
I've been on LDN fr nearly 4 years and Ifound within a week I had noticed I was staying up later and had a bit more energy.
it took me about two days before I started to feel the benefit. I thought that I would have side effects but I've had none, which for me is brilliant because I carn't take much every.thing is too strong for me.
Hi, I'm pretty new here so hi to all. I began seeing a difference within a week. I feel so lucky, that I spread the word on and off the web.
I also help with the LDN Trust.
A very,happy and grateful LDN user.
I have MS. For me...it was 2-4 weeks when I started feeling less fatigue and having more stamina! Soon followed by less brain fog, less anxiety....vertigo is very infrequent, muscle spasms, nerve twitches and numberness & tingling are gone now.
I remember the third night I was on LDN and I felt my Fibromyalgia trigger points open up in my neck and shoulders. It was similar to the feeling I used to get a couple of days after a pain specialist would give me trigger point injections with lidocaine. I was in disbelief that on an extremely low dose I could begin to experience less tightness and therefore less pain. For Hailey-Hailey Disease, it was a bit more subtle, but I noticed blisters drying up faster and less flare-ups.
I have had a progression of pain, spasm, pain in the legs, groin and now forearms. Fasciculations in the legs and face, pain is excruciating and debilitating causing falls with now the use of cane and walker. Continue to try and work with occasional tear wrenching pain. In addition to muscle relaxers and oxycodone which last for about 6-8 hours I can tolerate with difficulty to work. The doctor started me on LDN 2.25 three weeks ago and a week later increased to 4.50. The pain has continued to be unbearable in legs as well as testicles as the symptoms increase. Disappointed that I have not had any decrease in the symptoms as of yet and was wondering how long to keep trying this technique.
I notice you are taking Oxycodone along with LDN,
. My understanding is that At mg doses LDN can trigger opioid withdrawal and increased pain. For people on lipids ultra low doses between 1 _100 mfg or so has often helped with pain without causing withdrawal. My son started at 1 mfg twice daily and is now at 2 mfg thrice daily. Maybe discuss it with your doctor.
To Phyllis I am curious what dosage you are taking
Hi! I realize this post is from 6 years ago but I just stumbled across it and had to ask how are you still doing on the LDN? , and have you heard of the cream form being just as beneficial as the pill? Was just prescribed it by my doctor and I'm so hopeful that it will help for my depression ,PA and possibly CFS- still finding out if I may have that. Thanks!!
