Neuraly Announces Topline Results from Phase 2 Trial of NLY01 in Parkinson's Disease

finance.yahoo.com/news/neur...

Neuraly announces topline results of their randomized, double-blind, placebo-controlled trial designed to assess safety, tolerability, & efficacy of their GLP-1 receptor agonist NLY01 in 255 individuals with early, untreated Parkinsons.

- The primary endpoint, change from baseline in the sum of MDS-UPDRS Parts II and III after 36 weeks of NLY01 treatment, compared with placebo, did not reach statistical significance.

* Age was identified as a significant factor in response. Statistically significant and dose-related improvements in UPDRS Parts II + III were observed in patients under the age of 60.

* NLY01 was safe and well tolerated.

[kevowpd]

If the hypothesis is that these drugs are disease modifying, then one has to wonder what kind of difference you should expect between the modified and unmodified after less than 9 months in a group of PWPs with 'early, untreated Parkinsons'. Early PD can be quite stable for longer than 9 months at least in any manner than can currently be reliably measured.

[Parkinsonjisung in reply to kevowpd]

Agreed. Exenatide trial (similar drug) is 2 years so I believe that should be long enough to give some decent results. The trial reporting on Thursday is only over 3 months I think which doesnt seem at long enough to take results that would be meaningful

[AGH_1966 in reply to Parkinsonjisung]

Award for your name 😂

[Hidden in reply to kevowpd]

Good point

[Baron1 in reply to kevowpd]

This is the problem. They make claims that the disease (Parkinson's) is gradual and occurs over several years if not 10 years before any indications that a person has become a victim. So how can they think that the disease can modified in such a short time frame in a trial?

This is why I am convinced that the cure has already being found. But the studies were probably cut short because the end results did not justify continuing the studies. Perhaps a cure was discovered 10 years ago or more recently, from one of those thousand clinical trials.

Science and big Pharma are impatient sometimes, they use drug trials like a microwave cooking food, quick fix and time is minimal. When using an oven and cooking slowly gets a better result.

They all want the goose that lays the golden egg.

Lets hope that something is coming soon.

[AGH_1966 in reply to Baron1]

"This is why I am convinced that the cure has already being found. But the studies were probably cut short because the end results did not justify continuing the studies" - that is a very interesting comment. I have thought the same.

[Hidden in reply to Baron1]

I agree. So in a way you are saying it might be beneficial to do these kind of studies where the results are tailored in a way that the drugs hits market as soon as possible. Later, users will tell it is more or less disease modifying ?

[jeffreyn]

See also this recent PNT article:

parkinsonsnewstoday.com/new...