An interaction was found between rivaroxaban and an anti-epileptic drug, levetiracetam, where a patient had a series of TIAs. After extensive tests, his blood serum of rivaroxaban was found to be zero at times:
It is considered that this effect also applies to all the other DOACs as they act on the same pathway. Also that it applies to other anti-epileptic drugs as most of them also have a common pathway.
I do wonder what other drugs also affect DOACs as it is so difficult to measure their effectiveness.
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MarkS
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Nor is my hubby. He has been asked before about moving to a NOAC. Point blank refuses! You may remember a previous post where we were deciding what to do about his INR testing at surgery re COVID-19. The doc suggested changing ro a NOAC which he doesnt want to do as he is very sensitive to lots of meds unfortunately. There is also no regular testing for NOACs as we know. Interesting that it seems there was zero rivaroxaban in serum blood on occasions. I dont likecthe sound of that either The doc did say they could check the NOAC like they do the Warfarin but that would defeat the object of not going ro the surgwry. Thankfully a lovely lady on this site has sentvus an INR machine that she no longer uses. The doc also said that if he didnt have regular checks at the surgery they would have to take the warfarin away! Just hope she accepts him using the machine. He is pretty clued up on it and also INR testing. He has had to point out to surgery that they have been wrong once or twice with how much warfarin he should be taking!
Isle of Wight have stopped all patients from having INR checks, so no choice there. Hope they are giving patients something else?!
Hi Mark I have now changed to aphixaban not dissimilar to rivaroxaban but this was only done due to a supply issue, I was origionaly on warfarin but my GP called me in one day and told me I had been on it far too long I had at times been taking 15 mg as prescribed by my original GP , in his words he told me that if they tried to licence warfarin now they would not get it passed , as regards rivaroxaban I had been on this for about 7 years and had no side effects and not having to keep going for weekly tests when I was on warfarin was a massive plus. and as one of your previous responses has said I have never had an INR test since changing over rivaroxaban I took 5mg once daily the aphixaban I take 5mg twice daily ,I am also taking other meds for my heart - beta blockers, statins plus other meds for other issues, but as stated I have had no side effects, one last thing I would say is after my GP took me off the warfarin I learned that after having some blood tests for an unrelated issue that I have acute kidney disease I firmly believe that this was due to taking high levels of warfarin ?
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