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ISO a third MO opinion for my dad
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Dsmejkal88
in
Advanced Prostate Cancer
3 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
3 months ago
Clinical Trial PT 112 ?
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
Enilorac63
in
Advanced Prostate Cancer
3 months ago
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Is it PSA recurrence or not...
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
traveller64
in
Advanced Prostate Cancer
3 months ago
PSA vs Testosterone Nadir for CRPC and Non-CRPC
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
janebob99
in
Advanced Prostate Cancer
3 months ago
Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA Score Doubling / Lab Error?
Hey folks I was diagnosed back in 2017 with 3+3, later upgraded to 3+4, but with less then 5% of G4. Epstein reviewed and said he would go against Johns Hopkins policy to automatically treat ANY amount of G4 and stick with AS, at least in my situation. Before and since my diagnosis, my PSA score has
Hey folks I was diagnosed back in 2017 with 3+3, later upgraded to 3+4, but with less then 5% of G4. Epstein reviewed and said he would go against Johns Hopkins policy to automatically treat ANY amount of G4 and stick with AS, at least in my situation. Before and since my diagnosis, my PSA score has
PTvsPC
in
Prostate Cancer Network
3 months ago
Rising PSA post RP,IRT,ADT
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
3 months ago
First PSA after RARP
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
Pca2024
in
Advanced Prostate Cancer
3 months ago
Docxtel triple therapy?
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
Thank you for sharing your thoughts. My dad--81, advanced metastatic castrate resistant Diagnosed at 79 with stage 4 met 8 bones, including skull, no Gleason, never even saw a urologist. Diagnosed in ER and sent straight to the oncologist and palliative care doctor. PSA initially at 137 Lupron
lgutman
in
Advanced Prostate Cancer
3 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
3 months ago
Dad's PSA risen from 0.01 to 0.05 in 2 months, 2 years post SRT. Any chance that there is no further progression?
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
PSA has risen 3 times in a row. I understand the figure is still low, but is this a definite indication that it will progress, or is there a chance that PSA can stabilize or fluctuate and not progress further? Things have been difficult in the family, I am hoping for a miracle that he had a curative
MsBoBo
in
Advanced Prostate Cancer
3 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
3 months ago
PSA spiked from .6 to 8.0 in 3 months
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
crony
in
Advanced Prostate Cancer
3 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
3 months ago
Patches (I'm depending on you, son)
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
Dated pop reference - sorry. While my research has continued, my oncologist has nothing to give me within the SOC to keep the PSA in check. Now I've witnessed another unwelcome visitor: facial hair (it only took me 70 yrs to start shaving....) Joking aside however, that means the T is on the rise.
CrocodileShoes
in
Advanced Prostate Cancer
3 months ago
AUS revision surgery?
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
allnewstuff
in
Advanced Prostate Cancer
3 months ago
Pain Management
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Nyon
in
Advanced Prostate Cancer
3 months ago
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