So... I'm digging into PDTom 's post: Propionic acid (sodium propionate) - Does anyone have any experience? healthunlocked.com/cure-par...
And the feedback seems to be "Go Propionic Acid!" so I start Googling and not only find worrying posts about proprionate, but then results questioning the wisdom of supplementing Butyrate or boosting SCFAs at all.
I eat pistachios EVERY morning in an effort to boost my SCFAs. I'm not stopping, but I am researching.
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition 2021 elifesciences.org/articles/...
"Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown. Here, we identify microbiota-derived short chain fatty acids (SCFA) as microbial metabolites which promote Aβ deposition."
Propionate and Alzheimer’s Disease 2021 frontiersin.org/articles/10...
"Propionate serves important functions in the body. However, excess levels of propionate may play a role in AD. The cause of the excessive levels of propionate could be related to diet, medication use, the commensal microbiota, or potentially related to propionate metabolism. Future studies should aim to clarify the cause of the excess levels. There are multiple mechanisms by which propionate may lead to AD, including glutamate excitotoxicity and hyperammonemia. The mechanisms offer potential points for intervention."
(This is a good one and looks more positive?) Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic 2023 researchgate.net/publicatio...
"In this review, we comprehensively summarize the relation-ship between SCFAs and PD from pathology to the clinic. Significant alterations in SCFAs are present in patients with PD and are closely associated with motor symptoms and non-motor symptoms. SCFAs affect the pathological pro-gress of PD through multiple dimensions. In the future, more attention should be paid to the diagnostic and therapeutic value of SCFAs for PD. There are still some problems that need to be solved urgently. First, we need to clarify the regu-latory mechanism of SCFAs on microglia. Direct central regulation or indirect peripheral regulation? Second, the decrease in fecal SCFAs in PD patients is now a consensus, but the significance and alteration of plasma SCFAs need to be further confirmed, including in other tissues. Third, it is necessary to identify a stable and highly recognized PD model with specific non-motor symptoms to verify the thera-peutic potential of SCFAs in non-motor symptoms. Fourth, the value of SCFAs-producing probiotics, prebiotics, and synbiotics in PD deserves further development. Some short-comings in this review should also be noted. The study of SCFAs-producing bacteria in PD has not been summarized. In addition, we did not focus on the interaction between SCFAs and other metabolites. It is hoped that future research and reviews will add to these aspects."
Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in 465 Parkinson Disease (RESISTA-PD) 2020 clinicaltrials.gov/ct2/show...
"RS, as a dietary supplement to increase fiber intake, is safe and well-tolerated in PD. RS supplementation partially restores fecal SCFA concentrations in the PD + RS group without clear-cut changes in the gut microbiome that were attributable to the intervention. Alterations at the transcriptome level that are not captured by our approach might explain the intervention-associated significant increase in fecal markers in the PD + RS group." (Bolt reads: Not much of a result).
I don't know what this all means. I WILL keep eating my pistachios.
