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TAPUR study
Following up on a genomics report (47 pages ! Plus 54 min consult) and came across this study (phase 2 basket trial) in the US. Essentially when exhausting, or before, standard of care options, allows patients to trial off label approved drugs using genomics to identify specific targetable variations
Following up on a genomics report (47 pages ! Plus 54 min consult) and came across this study (phase 2 basket trial) in the US. Essentially when exhausting, or before, standard of care options, allows patients to trial off label approved drugs using genomics to identify specific targetable variations
muzzatron
in
SHARE Metastatic Breast Cancer
6 months ago
worried something missing
after having skin issues ie red burning rash and bloating and blood in stool and weight loss loss of hair and nails all got worse since original ct scan and of colonoscopy found pre cancerous poloyp hyperplasticity poloyp that weren’t all removed and mild diverticulitis and and endoscopy found ulcer
after having skin issues ie red burning rash and bloating and blood in stool and weight loss loss of hair and nails all got worse since original ct scan and of colonoscopy found pre cancerous poloyp hyperplasticity poloyp that weren’t all removed and mild diverticulitis and and endoscopy found ulcer
Doughnut83
in
Colon Cancer Connected
5 days ago
Confused about relatives diagnosis and treatment for colon cancer
Grandad is 87, diagnosed with colon cancer at the beginning of the year. Only symptom was rapidly decreasing iron in blood.They said he had stage T4 and that they were going to do an operation to remove the cancer. They did just that last week. Doctors said they had removed the cancer and he was released
Grandad is 87, diagnosed with colon cancer at the beginning of the year. Only symptom was rapidly decreasing iron in blood.They said he had stage T4 and that they were going to do an operation to remove the cancer. They did just that last week. Doctors said they had removed the cancer and he was released
Fenella34
in
Colon Cancer Connected
5 days ago
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Is serum folate levels the level of b12?
I received this as a blood result 3 weeks after receiving my b12 injection but I am confused. Does this tell me the level of b12 in my blood or folate? There are no other test results that refer to b12. I am currently suffering very badly with the symptoms of low b12 despite having my 3 monthly injections
I received this as a blood result 3 weeks after receiving my b12 injection but I am confused. Does this tell me the level of b12 in my blood or folate? There are no other test results that refer to b12. I am currently suffering very badly with the symptoms of low b12 despite having my 3 monthly injections
Lynne81
in
Pernicious Anaemia Society
6 days ago
Best diet and supplementation guide for hypothyroidism?
Is there a really simple list of vitamins (and best times of day to take them) and a list of foods to avoid when starting out of levothyroxine? I have such brain fog that I'm struggling to compile a plan for myself. I really need to lose the weight I've recently piled on too. Also I have ADHD so I struggle
Is there a really simple list of vitamins (and best times of day to take them) and a list of foods to avoid when starting out of levothyroxine? I have such brain fog that I'm struggling to compile a plan for myself. I really need to lose the weight I've recently piled on too. Also I have ADHD so I struggle
Granolalovers2
in
Thyroid UK
6 days ago
IBS / Diverticulosis
Does anyone suffer from a flare , UTI and diverticulitis at the same time ? This last flare started after a course of antibiotics for another infection. , but now I have felt really ill for the last few days with very tender abdomen and pain all along my left side even up under my left ribs ! I also
Does anyone suffer from a flare , UTI and diverticulitis at the same time ? This last flare started after a course of antibiotics for another infection. , but now I have felt really ill for the last few days with very tender abdomen and pain all along my left side even up under my left ribs ! I also
Mascot68
in
IBS Network
7 days ago
stomach bloating
I have pain starting from stomach then it seems to travel down to lower abdomen. I am very bloated, only burping or passing wind, my pain can be released a bit. The bloating is so bad, I couldn’t even breathe. I am wondering if anyone who have similar symptoms and how to relief such painful bloating.
I have pain starting from stomach then it seems to travel down to lower abdomen. I am very bloated, only burping or passing wind, my pain can be released a bit. The bloating is so bad, I couldn’t even breathe. I am wondering if anyone who have similar symptoms and how to relief such painful bloating.
Stomach2024
in
IBS Network
8 days ago
Help and understanding
Hi all, let me start with how much I love this site everyone is so helpful and understanding. I'm sorry if I go on a bit just sometimes things seem better when you write it down and get anothers view. I've had ibs c for 30 ish years. It was just constant constipation in the beginning. As the years went
Hi all, let me start with how much I love this site everyone is so helpful and understanding. I'm sorry if I go on a bit just sometimes things seem better when you write it down and get anothers view. I've had ibs c for 30 ish years. It was just constant constipation in the beginning. As the years went
Gizmo6
in
IBS Network
8 days ago
what is ibs?
Hi! new here and didn’t actually know this forum was about until I started googling on the nhs site. So my question is what is ibs? I want to explain what I’m experiencing and if someone can tell me if it’s completely normal for ibs to be like this I would be really grateful. This time last year
Hi! new here and didn’t actually know this forum was about until I started googling on the nhs site. So my question is what is ibs? I want to explain what I’m experiencing and if someone can tell me if it’s completely normal for ibs to be like this I would be really grateful. This time last year
HLeamon
in
IBS Network
8 days ago
Ca125 huge rise please help
My mother 's Ca 125 had a huge Spike from 2.74 last november to 11.42 at the begininng of May. CEA went Down instead. She changed Lab and this new Lab has a different range, the previous One used 0-21 and this One use the usual 0-35. She also had a ct scan , absolutely clear. She had , 15 days prior
My mother 's Ca 125 had a huge Spike from 2.74 last november to 11.42 at the begininng of May. CEA went Down instead. She changed Lab and this new Lab has a different range, the previous One used 0-21 and this One use the usual 0-35. She also had a ct scan , absolutely clear. She had , 15 days prior
Belindajames
in
My Ovacome
8 days ago
Esomeprazole and metoclopramide
Hello everyone I’ve been enjoying the posts on What’s in a Title and thank you to all involved. On a more mundane matter, I had a telephone consultation with I’m pleased to say, Dr Murray’s gastrointestinal/Scleroderma clinic over a week ago. It was with Kristina Clarke who I’ve met before and when
Hello everyone I’ve been enjoying the posts on What’s in a Title and thank you to all involved. On a more mundane matter, I had a telephone consultation with I’m pleased to say, Dr Murray’s gastrointestinal/Scleroderma clinic over a week ago. It was with Kristina Clarke who I’ve met before and when
Halfwayuphill
in
Scleroderma & Raynaud's UK (SRUK)
8 days ago
Happy holiday post!
Quick catch up to give a boost if you're struggling right now starting your journey 😘 Basics Stage4b hgsc hrd+ brca negative with lymph nodes next to my heart and pelvis, started carbo/taxol June 2021 had 4 rounds then paid private for operation then 2 rounds. Finished 22 infusions of avastin in April
Quick catch up to give a boost if you're struggling right now starting your journey 😘 Basics Stage4b hgsc hrd+ brca negative with lymph nodes next to my heart and pelvis, started carbo/taxol June 2021 had 4 rounds then paid private for operation then 2 rounds. Finished 22 infusions of avastin in April
Newbery3
in
My Ovacome
9 days ago
Stomach pain bam
Got diagnosed with bile acid malabsorption over a year ago terrible pain before and after bowel movements that lasts a good few hours seeing a different doctor at my surgery he said he could be the bile salts aggravating my colon so i have to up the colesevelam to 2 a day instead of 1 if that dont help
Got diagnosed with bile acid malabsorption over a year ago terrible pain before and after bowel movements that lasts a good few hours seeing a different doctor at my surgery he said he could be the bile salts aggravating my colon so i have to up the colesevelam to 2 a day instead of 1 if that dont help
Netbet22
in
IBS Network
9 days ago
Simethicone
Been having problems due to Pelvic Floor Dysfunction. Whilst it’s improved a little bit in the last few days I’m finding that trapped gas first thing when waking is an issue. I was looking at Simethicone and whether that or Deflatine would help me. I’ve got afib and on regular medication (flec and bisoprolol
Been having problems due to Pelvic Floor Dysfunction. Whilst it’s improved a little bit in the last few days I’m finding that trapped gas first thing when waking is an issue. I was looking at Simethicone and whether that or Deflatine would help me. I’ve got afib and on regular medication (flec and bisoprolol
Profound15
in
Atrial Fibrillation Support
9 days ago
Is my Endo back?
Hi Everyone, Looking for some advice or anyone who's been through a similar experience. I had Endo 3 years ago some of my main symptoms where bowel issues bloating, gassy, stomach cramps and diarrhea whenever I ate to much. Initially the doctor put it down to IBS. Obviously that wasn't the case and it
Hi Everyone, Looking for some advice or anyone who's been through a similar experience. I had Endo 3 years ago some of my main symptoms where bowel issues bloating, gassy, stomach cramps and diarrhea whenever I ate to much. Initially the doctor put it down to IBS. Obviously that wasn't the case and it
mo222
in
Endometriosis UK
9 days ago
High dose Turmeric and links to low ferritin
My ferritin has dropped from 82ug/L (30-150) 4 months ago to 64ug/L (30-264) this week (both Medichecks- Inuvi lab). I’ve been scratching my head to find out why this could be, as my diet hasn’t changed. https://amzn.eu/d/bTWoF2o The only change I’ve made is to increase my usual turmeric dose (which
My ferritin has dropped from 82ug/L (30-150) 4 months ago to 64ug/L (30-264) this week (both Medichecks- Inuvi lab). I’ve been scratching my head to find out why this could be, as my diet hasn’t changed. https://amzn.eu/d/bTWoF2o The only change I’ve made is to increase my usual turmeric dose (which
Buddy195
Administrator
in
Thyroid UK
10 days ago
hepatic Encephalopathy
morning, can anyone advice me about hepatic Encephalopathy ? I have stage 4 liver desease and was feeling so confused last night with things like time and thinking lights were off but were on is this the start of it? Last time I was like this was last march when I had my diagnoses, I take lactose which
morning, can anyone advice me about hepatic Encephalopathy ? I have stage 4 liver desease and was feeling so confused last night with things like time and thinking lights were off but were on is this the start of it? Last time I was like this was last march when I had my diagnoses, I take lactose which
Kingbilly3
in
British Liver Trust
10 days ago
Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
Maxone73
in
Advanced Prostate Cancer
11 days ago
Struggling with disimpaction regime
Hello, really hoping someone has some advice as I’m at the end of my tether! My son is 5, he has struggled with constipation since he was 6 months old. He went onto Movicol (just x1 sachet a day) which was working fine to keep his stools soft and passable however when he began potty training at 3y/o
Hello, really hoping someone has some advice as I’m at the end of my tether! My son is 5, he has struggled with constipation since he was 6 months old. He went onto Movicol (just x1 sachet a day) which was working fine to keep his stools soft and passable however when he began potty training at 3y/o
Lem14
in
ERIC
11 days ago
Vitamin B12 Sublingual - Why do I feel sleepy?
Hello Everyone Just took a tablet of Vitamin B12 Sublingual today morning just after breakfast and felt v sleepy and took a short nap after noon. Is this expected? Has anyone experienced this? This is the brand that I bought: https://www.cytoplan.co.uk/vitamin-b12-sublingual-as-methylcobalamin-adenosylcobalamin
Hello Everyone Just took a tablet of Vitamin B12 Sublingual today morning just after breakfast and felt v sleepy and took a short nap after noon. Is this expected? Has anyone experienced this? This is the brand that I bought: https://www.cytoplan.co.uk/vitamin-b12-sublingual-as-methylcobalamin-adenosylcobalamin
BookLover2020
in
Thyroid UK
11 days ago
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