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New drug approved for those with KRAS G-12C
On December 12th, 2022, the Food and Drug Administration (FDA) approved Krazati (adagrasib) for treatment of non-small cell lung cancer (nsclc) where there is a KRAS G12C mutation. This approval is for patients who have received at least one line of prior treatment such as chemotherapy. The FDA based
On December 12th, 2022, the Food and Drug Administration (FDA) approved Krazati (adagrasib) for treatment of non-small cell lung cancer (nsclc) where there is a KRAS G12C mutation. This approval is for patients who have received at least one line of prior treatment such as chemotherapy. The FDA based
Miranda_GO2
Partner
in
Lung Cancer Support
1 year ago
Urso blocks COVID - research today from Addenbrooke's Hospital, Cambridge
15h Dec 2022 at 14:15 UK time : On the BBC World Service programme Healthcheck, right now. Liver consultant from Addenbrooke's reporting that they have discovered that Urso protects against COVID. Medic says that Urso blocks COVID's ability to enter human cells. 'It shuts the doorway (into the cell
15h Dec 2022 at 14:15 UK time : On the BBC World Service programme Healthcheck, right now. Liver consultant from Addenbrooke's reporting that they have discovered that Urso protects against COVID. Medic says that Urso blocks COVID's ability to enter human cells. 'It shuts the doorway (into the cell
Wilderswimmer
in
PBCers Organization
1 year ago
Delivery of mRNA therapies: Moderna's founder Bob Langer discusses past, present, and future
[i]"mRNA is expected to become one of the major pillars of drug development. With an increasing number of concepts entering clinical trials, the first approval of an mRNA therapeutic against cancer is nearing" [/i]are the concluding lines of a review paper published in April 2021 https://molecular-cancer.biomedcentral.com
[i]"mRNA is expected to become one of the major pillars of drug development. With an increasing number of concepts entering clinical trials, the first approval of an mRNA therapeutic against cancer is nearing" [/i]are the concluding lines of a review paper published in April 2021 https://molecular-cancer.biomedcentral.com
bennevisplace
in
CLL Support
1 year ago
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Update
I think I have to eat my words. My private appointment for echocardiogram etc is booked for next Tuesday. Today I received a call from cardiology at my local hospital advising me my blood result had been automatically referred to them and I am to attend for echo ecg then see a doctor this Friday at 10pm
I think I have to eat my words. My private appointment for echocardiogram etc is booked for next Tuesday. Today I received a call from cardiology at my local hospital advising me my blood result had been automatically referred to them and I am to attend for echo ecg then see a doctor this Friday at 10pm
Florence-Nightingale
in
AF Association
2 years ago
The Vaccines are coming[b] [/b]
https://www.yahoo.com/now/moderna-merck-announce-mrna-4157-120000391.html Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial Moderna, Inc. Tue,
https://www.yahoo.com/now/moderna-merck-announce-mrna-4157-120000391.html Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial Moderna, Inc. Tue,
Scout4answers
in
Advanced Prostate Cancer
1 year ago
18 Month Update
Brief Summary Gleason 4+5 with Intraductal histology T3b n1 Brca2. After 18 months of ADT plus Abiraterone and HDR Brachytherapy and EBRT my WBC is within normal limits for the first time since HDR Brachytherapy. My PSA started at 10.28 and decreased 95% the first month of ADT and slowly after that
Brief Summary Gleason 4+5 with Intraductal histology T3b n1 Brca2. After 18 months of ADT plus Abiraterone and HDR Brachytherapy and EBRT my WBC is within normal limits for the first time since HDR Brachytherapy. My PSA started at 10.28 and decreased 95% the first month of ADT and slowly after that
TylexGP
in
Advanced Prostate Cancer
1 year ago
Afib after Ablation
Had the same issue after my Ablation. Had two cardioversion to put back into NSR. I was on Metropolol but it had no effect was getting sick and tired of it. My Cardiologist put me on Sotalol 80mg twice a day made all the difference in the world have afib free for Seven months now. It took a about Four
Had the same issue after my Ablation. Had two cardioversion to put back into NSR. I was on Metropolol but it had no effect was getting sick and tired of it. My Cardiologist put me on Sotalol 80mg twice a day made all the difference in the world have afib free for Seven months now. It took a about Four
Nifty65
in
AF Association
2 years ago
Is ADT beneficial after castration resistance sets in?
If PSA is rising at the same doubling time (3 weeks) as it was without ADT (when I was Castration sensitive and did intermittent ADT breaks), then is it useful to keep taking ADT? If so, why? Is that because the ADT would be slowing some castration sensitive cancer, even though the castration resistant
If PSA is rising at the same doubling time (3 weeks) as it was without ADT (when I was Castration sensitive and did intermittent ADT breaks), then is it useful to keep taking ADT? If so, why? Is that because the ADT would be slowing some castration sensitive cancer, even though the castration resistant
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Starting my prostate cancer journey after radical prostatectomy. Looking for info, suggestions or recommendations on future treatments.
Hello everyone, I am 67 and had a PSA of 8.9 and a grade group 4 Gleason score of 4+4=8. I had radical prostatectomy with lymph node dissection on 12/1/2022. I am on the road to recovery. The pathology report showed 60-70 % of prostate involved by tumor with extraprostatic extension present, non
Hello everyone, I am 67 and had a PSA of 8.9 and a grade group 4 Gleason score of 4+4=8. I had radical prostatectomy with lymph node dissection on 12/1/2022. I am on the road to recovery. The pathology report showed 60-70 % of prostate involved by tumor with extraprostatic extension present, non
MrDexter
in
Advanced Prostate Cancer
1 year ago
Experimental cancer therapy shows success in more than 70% of patients in global clinical trials
Myeloma is only cancer mentioned https://medicalxpress.com/news/2022-12-experimental-cancer-therapy-success-patients.html?utm_source=join1440&utm_medium=email&utm_placement=newsletter
Myeloma is only cancer mentioned https://medicalxpress.com/news/2022-12-experimental-cancer-therapy-success-patients.html?utm_source=join1440&utm_medium=email&utm_placement=newsletter
Scout4answers
in
Advanced Prostate Cancer
1 year ago
Suddenly Glad....
In my first post to the community, I was wondering if I should get an ablation or not, based on the advice of a somewhat snarky cardiologist. Since then, I have had a second opinion from both a new cardiologist and a new electrophysiologist. BOTH said they saw no reason to rush into this. The cardiologist
In my first post to the community, I was wondering if I should get an ablation or not, based on the advice of a somewhat snarky cardiologist. Since then, I have had a second opinion from both a new cardiologist and a new electrophysiologist. BOTH said they saw no reason to rush into this. The cardiologist
Elsie1955
in
Atrial Fibrillation Support
2 years ago
admitted to A& E with PAF
anyone else find that their PAF is set off after lots of exercise? Had a busy energetic week on holiday followed by a 34 mile e-bike ride then developed AF nothing worked tried everyone’s suggestions and Bisoperol so into A& E at 20.30 hoping to be cardioverted and sent home but no luck! Dr didn’t really
anyone else find that their PAF is set off after lots of exercise? Had a busy energetic week on holiday followed by a 34 mile e-bike ride then developed AF nothing worked tried everyone’s suggestions and Bisoperol so into A& E at 20.30 hoping to be cardioverted and sent home but no luck! Dr didn’t really
09Bumblebee
in
AF Association
2 years ago
Feeling really down
I am week 7 post my first cryoablation for paroxysmal AFib. For the first week or so I had NSR fluctuations with mild AFib. Since 6th September I have been in constant AFib with HR ranging from 80-120bpm. I have tried and failed to get any real advice from AFib nurses and the EP who did my procedure
I am week 7 post my first cryoablation for paroxysmal AFib. For the first week or so I had NSR fluctuations with mild AFib. Since 6th September I have been in constant AFib with HR ranging from 80-120bpm. I have tried and failed to get any real advice from AFib nurses and the EP who did my procedure
Kennyb1968
in
Atrial Fibrillation Support
2 years ago
Fine-Tuning the Wave of Innovation in CLL
ASH2022 is happening in New Orleans, right now. Yesterday, there was a great webinar hosted on the PeerView platform that covered Personalized Models for Upfront and Sequential Care With Groundbreaking Treatment, which should be of interest to anyone contemplating firstline or relapsed/refractory treatment
ASH2022 is happening in New Orleans, right now. Yesterday, there was a great webinar hosted on the PeerView platform that covered Personalized Models for Upfront and Sequential Care With Groundbreaking Treatment, which should be of interest to anyone contemplating firstline or relapsed/refractory treatment
SeymourB
in
CLL Support
1 year ago
Treatment of Richter's syndrome - ASH 2022 Education Program
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
CLLerinOz
Administrator
in
CLL Support
1 year ago
Lu-177 as SOC vs Clinical Trial
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
MechD
in
Advanced Prostate Cancer
1 year ago
Post Ablation change in meds
I have/had PAF and had been taking Sotalol 120 2x daily, Diltiazem 120 1x and Eliquis before my ablation which occurred in January 2022. Since I had no further occurrences of Afib, my EP reduced the Sotalol to 80 2x in April. During my follow up visit with my EP this week he discontinued the Sotalol
I have/had PAF and had been taking Sotalol 120 2x daily, Diltiazem 120 1x and Eliquis before my ablation which occurred in January 2022. Since I had no further occurrences of Afib, my EP reduced the Sotalol to 80 2x in April. During my follow up visit with my EP this week he discontinued the Sotalol
MJZaw
in
AF Association
2 years ago
How bad is it?
Does anyone understand BNP levels mine is 2963ng/L I think normal is between 0.0. 150. I think it indicates heart failure but not sure. Before I can have echocardiogram privately I need referral from GP who would you believe it is off sick!!
Does anyone understand BNP levels mine is 2963ng/L I think normal is between 0.0. 150. I think it indicates heart failure but not sure. Before I can have echocardiogram privately I need referral from GP who would you believe it is off sick!!
Florence-Nightingale
in
AF Association
2 years ago
New drug for treating hot flashes under FDA review
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
garyjp9
in
Advanced Prostate Cancer
1 year ago
Chemo/Pluvicto or Clinical Trial?
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
carguy
in
Advanced Prostate Cancer
1 year ago
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