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JAK2 V617F Allele Burden and Thrombotic Events in Patients w/ JAK2 V617F Positive PCV/ET @ High Risk of Thrombosis
The cumulative incidence of
thrombosis
at 7 years was 35.5%.
Arterial
thrombosis
(93.8%) predominated. Median overall survival was 103.6 months (95% CI 68.8–138.4). Median thrombosis-free survival was 86 months (95% CI 68.4–103.6).
The cumulative incidence of
thrombosis
at 7 years was 35.5%.
Arterial
thrombosis
(93.8%) predominated. Median overall survival was 103.6 months (95% CI 68.8–138.4). Median thrombosis-free survival was 86 months (95% CI 68.4–103.6).
PhysAssist
in
MPN Voice
29 days ago
Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management
Additional predictors for
arterial
thrombosis
include cardiovascular risk factors and for venous thrombosis higher absolute neutrophil count and JAK2V617F allele burden. Treatment Current goal of therapy is to prevent thrombosis.
Additional predictors for
arterial
thrombosis
include cardiovascular risk factors and for venous thrombosis higher absolute neutrophil count and JAK2V617F allele burden. Treatment Current goal of therapy is to prevent thrombosis.
Manouche
in
MPN Voice
11 months ago
How long for platelets to go back up?
Hello Since the start of my husband's cirrhosis journey last August, with a variceal bleed, his platelets went as low as 2700. Since then they rose to 6000 at one point and are now back down to 5000. I thought they would have gone much more by now but he is also on blood thinners because he has portal
Hello Since the start of my husband's cirrhosis journey last August, with a variceal bleed, his platelets went as low as 2700. Since then they rose to 6000 at one point and are now back down to 5000. I thought they would have gone much more by now but he is also on blood thinners because he has portal
looby24
in
British Liver Trust
2 months ago
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Immunoglobulin tests
Hi again. Yesterday I asked my GP if I could have my blood immunoglobulin levels checked as I like to keep a handle on those parameters which can indicate the status of my immune system. To be honest, I thought this would be done without question and routinely. However, my doc prefers that my CLL haematologist
Hi again. Yesterday I asked my GP if I could have my blood immunoglobulin levels checked as I like to keep a handle on those parameters which can indicate the status of my immune system. To be honest, I thought this would be done without question and routinely. However, my doc prefers that my CLL haematologist
Fogey
in
CLL Support
2 months ago
difference between portal vein thrombosis and portal hypertension?
Good evening. New here. Husband in hospital with liver cirrhosis. Having scope on Monday and we were told today that he has portal vein thrombosis. I understand what that is but I’m confused after doing some research as to the difference between portal vein thrombosis and portal vein hypertension? Or
Good evening. New here. Husband in hospital with liver cirrhosis. Having scope on Monday and we were told today that he has portal vein thrombosis. I understand what that is but I’m confused after doing some research as to the difference between portal vein thrombosis and portal vein hypertension? Or
Lvbv
in
British Liver Trust
3 months ago
The role of JAK2V617F allele burden in PV
Conclusion « The knowledge of the JAK2V617F mutation in relation to PV has allowed both physicians and patients to understand that risk is not inherently based on blood counts alone but also due to the effects of JAK2V617F VAF on thrombosis and disease progression. Prospective trials are now highlighting
Conclusion « The knowledge of the JAK2V617F mutation in relation to PV has allowed both physicians and patients to understand that risk is not inherently based on blood counts alone but also due to the effects of JAK2V617F VAF on thrombosis and disease progression. Prospective trials are now highlighting
Manouche
in
MPN Voice
7 months ago
Necrosing spleen
Does anyone have any experience of having a spleen embolisation? If so, did their spleen carry on necrosis 5 months later? Has anyone had a drain for 5 months outputting necrosing puss? How long were they in hospital for? My bother has PV and portal vein thrombosis and was directed to have radical
Does anyone have any experience of having a spleen embolisation? If so, did their spleen carry on necrosis 5 months later? Has anyone had a drain for 5 months outputting necrosing puss? How long were they in hospital for? My bother has PV and portal vein thrombosis and was directed to have radical
DeKa
in
MPN Voice
9 months ago
Purpura on w&w?
Since diagnosis 3 years ago, while on W&W, I have had presume purpura spots come and go on my left arm, but today, after reaching in to tomato cages to capture the best and presumably scraping my arm, I have developed a whole big area of what I assume to be purpura, spread over about 3 inches and not
Since diagnosis 3 years ago, while on W&W, I have had presume purpura spots come and go on my left arm, but today, after reaching in to tomato cages to capture the best and presumably scraping my arm, I have developed a whole big area of what I assume to be purpura, spread over about 3 inches and not
Vlaminck
in
CLL Support
9 months ago
Spleen embolisation gone wrong
Hello, Does anyone have any experience of why anyone with Polycythemia Vera and Portal Vein Thrombosis, with a 22cm spleen would be offered a partial splenectomy, a spleen embolisation through the groin? Has anyone been through this? My 48 year old brother went through this on 3rd April 2023 and
Hello, Does anyone have any experience of why anyone with Polycythemia Vera and Portal Vein Thrombosis, with a 22cm spleen would be offered a partial splenectomy, a spleen embolisation through the groin? Has anyone been through this? My 48 year old brother went through this on 3rd April 2023 and
DeKa
in
MPN Voice
10 months ago
What is the Importance of Platelet Counts in MPNs
From our friends ay MyMPNTeam. The interview with Dr. Kuykendall is informative and easily understood. There is an article based on the interview too. [i]“This association between high platelets and thrombotic events has been looked at in a variety of fashions over the past 50 years now, and really
From our friends ay MyMPNTeam. The interview with Dr. Kuykendall is informative and easily understood. There is an article based on the interview too. [i]“This association between high platelets and thrombotic events has been looked at in a variety of fashions over the past 50 years now, and really
hunter5582
in
MPN Voice
1 year ago
Recovery from pneumonia
70 YO F with bronchiectasis - I developed double pneumonia 3 months ago and completed 2 weeks of IV antibiotic treatment in hospital and at home 2 months ago. Is it normal for recovery from pneumonia to wax and wane, to be "nonlinear"? I was getting better 2 weeks ago, the fatigue was starting to lift
70 YO F with bronchiectasis - I developed double pneumonia 3 months ago and completed 2 weeks of IV antibiotic treatment in hospital and at home 2 months ago. Is it normal for recovery from pneumonia to wax and wane, to be "nonlinear"? I was getting better 2 weeks ago, the fatigue was starting to lift
eoram25
in
Lung Conditions Community Forum
10 days ago
nose bleed
was rushed to hospital 2weeks ago for pneumonia. Was discharged after a week. Wasn’t home 24 hrs. And out of the blue my nose started bleeding. It hasn’t stopped. Has this happened to anyone else and what did the doctors do to stop it?
was rushed to hospital 2weeks ago for pneumonia. Was discharged after a week. Wasn’t home 24 hrs. And out of the blue my nose started bleeding. It hasn’t stopped. Has this happened to anyone else and what did the doctors do to stop it?
Daytym
in
British Liver Trust
14 days ago
wanting to share the news
Hi , I have had my CT scan and blood work again I just to say there is no evidence of disease!!!!!! It was last year had my removal of all my bits and then chemo and a stay in ICU with septic shock but I’m still here , I know it’s early stages yet and anything can happen in the future but I GOT THERE
Hi , I have had my CT scan and blood work again I just to say there is no evidence of disease!!!!!! It was last year had my removal of all my bits and then chemo and a stay in ICU with septic shock but I’m still here , I know it’s early stages yet and anything can happen in the future but I GOT THERE
Cazy1010
in
My Ovacome
14 days ago
Septic shock
My partner has been in ICU for six days with septic shock affecting all organs and iGAS. He's still fully sedated but now able to come off some meds. He was already struggling with severe bronchiectasis, depression and PTSD before this. I arrived home from work and had to phone the ambulance. Blaming
My partner has been in ICU for six days with septic shock affecting all organs and iGAS. He's still fully sedated but now able to come off some meds. He was already struggling with severe bronchiectasis, depression and PTSD before this. I arrived home from work and had to phone the ambulance. Blaming
Bee808
in
ICUsteps
16 days ago
Pneumonia and collapsed lung after catching the ‘100 day cough’
For all you folks who have Lupus, please be careful of this ‘100’ day cough that is going around at the moment, as this is what caused me to end up in hospital. I was diagnosed with Lupus in February 2022. I’ve had a rough ride for the past few years, ending up in hospital every year for one thing
For all you folks who have Lupus, please be careful of this ‘100’ day cough that is going around at the moment, as this is what caused me to end up in hospital. I was diagnosed with Lupus in February 2022. I’ve had a rough ride for the past few years, ending up in hospital every year for one thing
Loopy1971
in
LUPUS UK
28 days ago
Help. Icu
Hi all I'm new here but I'm also lost and don't know what to do. My mom currently needs a liver transplant but she has pneumonia and they had her sedated now she's awake but won't listen to orders.
Hi all I'm new here but I'm also lost and don't know what to do. My mom currently needs a liver transplant but she has pneumonia and they had her sedated now she's awake but won't listen to orders.
Joccelyn
in
ICUsteps
1 month ago
PMR & Cellulitis
Hi, some of you may remember that I posted a while back asking for tips to cope with long haul flights. Well, I arrived in Australia 6 weeks ago and didn’t have any problems after the flights, I just took an extra dose of Pred as suggested. However, two weeks ago I developed cellulitis in my left leg
Hi, some of you may remember that I posted a while back asking for tips to cope with long haul flights. Well, I arrived in Australia 6 weeks ago and didn’t have any problems after the flights, I just took an extra dose of Pred as suggested. However, two weeks ago I developed cellulitis in my left leg
GreatGranny4
in
PMRGCAuk
1 month ago
PMR & Cellulitis
Hi, some of you may remember that I Tposted a while back asking for tips to cope with long haul flights. Well, I arrived in Australia 6 weeks ago and didn’t have any problems after the flights, I just took an extra dose of Pred as suggested. However, two weeks ago I developed cellulitis in my left
Hi, some of you may remember that I Tposted a while back asking for tips to cope with long haul flights. Well, I arrived in Australia 6 weeks ago and didn’t have any problems after the flights, I just took an extra dose of Pred as suggested. However, two weeks ago I developed cellulitis in my left
GreatGranny4
in
PMRGCAuk
1 month ago
Streptococcal Bacterial Meningitis
Hi, everyone! I was admitted to the hospital on March 11 and diagnosed with Streptococcal Bacterial Meningitis and hospitalized for 17 days. Just released last Thursday. This was all brought on by an ear infection that I guess turned into meningitis. I had all the tests and scans and was told I was lucky
Hi, everyone! I was admitted to the hospital on March 11 and diagnosed with Streptococcal Bacterial Meningitis and hospitalized for 17 days. Just released last Thursday. This was all brought on by an ear infection that I guess turned into meningitis. I had all the tests and scans and was told I was lucky
Fjreed23
in
Meningitis Now
1 month ago
How can I help my intubated father in ICU?
I am desperately frightened as my father is fighting for his life, he has septic shock due to a liver abscess which has resulted in complications to his kidneys, brain and liver. Yesterday I saw him and he was so sleepy he could barely open his eyes and speak, although he was able to tell me he was in
I am desperately frightened as my father is fighting for his life, he has septic shock due to a liver abscess which has resulted in complications to his kidneys, brain and liver. Yesterday I saw him and he was so sleepy he could barely open his eyes and speak, although he was able to tell me he was in
Pluto8
in
ICUsteps
1 month ago
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