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Any updates on the 2019 Italian work on CRISPR-CAS9 that anyone knows about?
I am referring to this article: Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670138/ https://www.labiotech.eu/trends-news/crispr-deletion-interleukin
I am referring to this article: Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670138/ https://www.labiotech.eu/trends-news/crispr-deletion-interleukin
PCreader
in
Advanced Prostate Cancer
5 months ago
Please suggest "must read" articles for men diagnosed with an advanced stage of prostate cancer
If your prostate cancer knowledge seeking includes reading peer-reviewed articles, please suggest "must read" articles for men diagnosed with an advanced stage of prostate cancer and perhaps for their family members, too.
If your prostate cancer knowledge seeking includes reading peer-reviewed articles, please suggest "must read" articles for men diagnosed with an advanced stage of prostate cancer and perhaps for their family members, too.
Darryl
Partner
in
Advanced Prostate Cancer
5 months ago
PSA suppression
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
My PSA lows tend to be around 3.3, and it occurs to me that some might think it odd that I don't drive it lower. I think it is very common for men on ADT to draw too much comfort from a significant PSA reduction, if not a near-zero PSA. I have witnessed men misinterpret a dramatic drop in PSA as
pca2004
in
Fight Prostate Cancer
5 months ago
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I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
I saw my PSA suddenly rise to 3.67 in January 2023. My PMD was not overly concerned as it was under 4. His plan was to repeat it in 6 months. I will also not I was on Tamsulosin and Finasteride for some time at that point for urinary frequency. That started several years before (at that time I was
Cleantop
in
Advanced Prostate Cancer
5 months ago
chronic rectal bleeding, colonoscopy normal
I have been dealing with chronic rectal bleeding for at least 8 months, if not more. Been blown off by doctors. My family doctor finally sent me to a general surgeon who ordered a colonoscopy. Was instantly not a fan of him. My consultation was literally a minute long. He was very arrogant, and didn’
I have been dealing with chronic rectal bleeding for at least 8 months, if not more. Been blown off by doctors. My family doctor finally sent me to a general surgeon who ordered a colonoscopy. Was instantly not a fan of him. My consultation was literally a minute long. He was very arrogant, and didn’
Bulldogmomma73
in
Colon Cancer Connected
5 months ago
walnuts
hello, I’m post breast cancer treatment and on tamoxifen. There’s been a bit of thyroxine wobbling as I started that so being monitored. I’m eating more nuts, particularly / including walnuts (good for Bc) for extra protein as I’m exercising and lifting weights. how long would you wait before
hello, I’m post breast cancer treatment and on tamoxifen. There’s been a bit of thyroxine wobbling as I started that so being monitored. I’m eating more nuts, particularly / including walnuts (good for Bc) for extra protein as I’m exercising and lifting weights. how long would you wait before
haggisplant
in
Thyroid UK
5 months ago
Some good advancements today too: Advances in Engineered Macrophages - A New Frontier in Cancer Immunotherapy
"These cells act synergistically in tumour progression, invasion, metastasis, and response to immunotherapies. Consequently, cancer treatment has transitioned from a model centred solely on the cancer itself to one focused on the
tumour microenvironment
, and cancer immunotherapy has consequently
"These cells act synergistically in tumour progression, invasion, metastasis, and response to immunotherapies. Consequently, cancer treatment has transitioned from a model centred solely on the cancer itself to one focused on the
tumour microenvironment
, and cancer immunotherapy has consequently
Maxone73
in
Advanced Prostate Cancer
2 months ago
Improved Posts and Replies
Responding to ChatGPT charging $20 per month to use the advanced versions of Cancer Copilot and Clinical Trial Navigator: We found a way where you won't have to pay. Starting this month, "Advanced Prostate Cancer" will be power-charged by our AI engine…for free. We know many people have been shy about
Responding to ChatGPT charging $20 per month to use the advanced versions of Cancer Copilot and Clinical Trial Navigator: We found a way where you won't have to pay. Starting this month, "Advanced Prostate Cancer" will be power-charged by our AI engine…for free. We know many people have been shy about
Darryl
Partner
in
Advanced Prostate Cancer
2 months ago
PSMA and bladder Cancer?
I have been having various difficulties with urination and know that my bladder is messed up. I have radiation cystitis and who knows what else. I saw my urologist recently and he had little to offer, sort of said yes you are a mess and pretty much left it at that. I have had PSMA pet scans and SPECT
I have been having various difficulties with urination and know that my bladder is messed up. I have radiation cystitis and who knows what else. I saw my urologist recently and he had little to offer, sort of said yes you are a mess and pretty much left it at that. I have had PSMA pet scans and SPECT
spencoid2
in
Advanced Prostate Cancer
2 months ago
WellCare Plan D specialty pharmacy
My husband had Aetna Silverscript Part D and was using BioPlus specialty pharmacy for abiraterone. He switched to WellCare Part D and is having trouble getting his abiraterone prescription to the right department. When he’s called WellCare, he’s just been shuffled around and no one seems to be able
My husband had Aetna Silverscript Part D and was using BioPlus specialty pharmacy for abiraterone. He switched to WellCare Part D and is having trouble getting his abiraterone prescription to the right department. When he’s called WellCare, he’s just been shuffled around and no one seems to be able
Jewelrylady
in
Advanced Prostate Cancer
5 months ago
new immune therapy phase 1-2 trial: targeting NK cells
The first patient with metastatic castration-resistant prostate cancer (mCRPC) has been dosed in the phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy https://www.targetedonc.com/view/first-patient-dosed-with-inkmune-therapy-in-phase-1-2-trial-for-mcrpc
The first patient with metastatic castration-resistant prostate cancer (mCRPC) has been dosed in the phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy https://www.targetedonc.com/view/first-patient-dosed-with-inkmune-therapy-in-phase-1-2-trial-for-mcrpc
Maxone73
in
Advanced Prostate Cancer
5 months ago
Update On Eclipse Trial-another failure. Has LU-177 worked for anyone?
In 2010 at the age of 59, I had Da Vinci surgery with a Gleason 4+5=9 and PSA of 9. Post surgical biopsy showed all margins clear with no seminal vesicle involvement and Gleason post-op score was changed to a 4+3=7. Subsequent PSA was non-detectable as tested every three months for the first two years
In 2010 at the age of 59, I had Da Vinci surgery with a Gleason 4+5=9 and PSA of 9. Post surgical biopsy showed all margins clear with no seminal vesicle involvement and Gleason post-op score was changed to a 4+3=7. Subsequent PSA was non-detectable as tested every three months for the first two years
SViking
in
Advanced Prostate Cancer
5 months ago
Long term ADT bone loss mitigation tips?
My post RP BCR was diagnosed 8 months ago when they said, "you will be on ADT the rest of your life". I am on Lupron and abiraterone 4 months now. I am taking 1000mg of calcium per day and 2000IU of D3 per day. If I am lucky enough to last years, what else can I do to prevent the loss of bone? Thanks
My post RP BCR was diagnosed 8 months ago when they said, "you will be on ADT the rest of your life". I am on Lupron and abiraterone 4 months now. I am taking 1000mg of calcium per day and 2000IU of D3 per day. If I am lucky enough to last years, what else can I do to prevent the loss of bone? Thanks
jackwfrench
in
Prostate Cancer Network
5 months ago
Kaiser Fresno has stopped prescribing Xtandi, even for people midstream with it. they are switching over to xytega and prednisone.
just what it says. I went to renew my monthly , extremely effective , Xtandi a couple of days ago and today I’ve been told that my Xtandi prescription has been canceled, and I see on my prescriptions list, Zytiga and prednisone. Never a single word from anybody about this for anything. Basically I’m
just what it says. I went to renew my monthly , extremely effective , Xtandi a couple of days ago and today I’ve been told that my Xtandi prescription has been canceled, and I see on my prescriptions list, Zytiga and prednisone. Never a single word from anybody about this for anything. Basically I’m
Kaliber
in
Advanced Prostate Cancer
5 months ago
BAT and Pluvicto?
Did well on Zoladex and Apalutimide for 2 1/2 yrs. with Mets to bones. Cancer has now spread to liver and pelvic lymph nodes. Docetaxel has failed and I am now waiting to hear if insurance will cover Pluvicto. Any thoughts on starting BAT now in case Pluvicto doesn’t happen? Can you do both at the
Did well on Zoladex and Apalutimide for 2 1/2 yrs. with Mets to bones. Cancer has now spread to liver and pelvic lymph nodes. Docetaxel has failed and I am now waiting to hear if insurance will cover Pluvicto. Any thoughts on starting BAT now in case Pluvicto doesn’t happen? Can you do both at the
Vinny59
in
Advanced Prostate Cancer
5 months ago
ADT SE’s
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
I had a 6 month Lupron shot in April last year. I experienced all the typical SE the worst being the hot flashes at night. I am following the Ssport protocol for a biological reoccurrence. Basically a 6 month adt with 39 radiation treatments last year. Current labs show undetectable PSA with a slow
plato123
in
Advanced Prostate Cancer
5 months ago
IMRT WITHOUT THE JELL
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
woppaginny
in
Advanced Prostate Cancer
2 months ago
Rising PSA … Clear PSMA SCAN
My husband sees Dr. Rahul Aggarwal at UCSF. I’m surprised by his treatment plan. hubby has been on Lupron & NUBEQA since April. At first it brought PSA down but now it is up to 6.5 His last PSMA SCAN was in October when PSA was 4.3 Next PSMA scan is mid January. Aggarwal says PSA # is no longer of
My husband sees Dr. Rahul Aggarwal at UCSF. I’m surprised by his treatment plan. hubby has been on Lupron & NUBEQA since April. At first it brought PSA down but now it is up to 6.5 His last PSMA SCAN was in October when PSA was 4.3 Next PSMA scan is mid January. Aggarwal says PSA # is no longer of
JolleySprings
in
Advanced Prostate Cancer
5 months ago
Happy New Year and Update
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Scout4answers
in
Advanced Prostate Cancer
5 months ago
CRISPR: promising in vitro but I can barely understand it!
In Vitro Prostate Cancer Treatment via CRISPR-Cas9 Gene Editing Facilitated by Polyethyleneimine-Derived Graphene Quantum Dots. https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/148829-in-vitro-prostate-cancer-treatment-via-crispr-cas9-gene-editing-facilitated-by-polyethyleneimine-derived-graphene-quantum-dots.html
In Vitro Prostate Cancer Treatment via CRISPR-Cas9 Gene Editing Facilitated by Polyethyleneimine-Derived Graphene Quantum Dots. https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/148829-in-vitro-prostate-cancer-treatment-via-crispr-cas9-gene-editing-facilitated-by-polyethyleneimine-derived-graphene-quantum-dots.html
Maxone73
in
Advanced Prostate Cancer
5 months ago
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