Very interesting article: Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression 2024 gilmorehealth.com/tetanus-v...
It is based on this paper: Tetanus vaccination is associated with decreased incidence of Parkinson’s disease and slower progression 2024medrxiv.org/content/10.1101...
Abstract
Parkinson’s disease (PD) is characterized by progressive neurodegeneration in the autonomic and central nervous systems, manifesting with hallmark symptoms of rest tremor and bradykinesia. Its etiology remains poorly understood, and currently available treatments do not halt disease progression.
Here we analyze the impact of vaccination and medication purchase on PD occurrence and disease severity in a national health provider, employing a novel machine learning method.
We show that anti-tetanus vaccination significantly reduces PD occurrence, and that both the rate and severity of PD are strongly associated with the time elapsed since last vaccination. These results, which suggest that C. Tetani toxin is involved in PD pathology, are reinforced by findings that antimicrobial treatments that affect Clostridium species are associated with significant changes in disease severity.
Tetanus vaccination and clostridium eradication are promising strategies to prevent PD and slow its progression, pending controlled trials.
Parkinson’s disease (PD) is a neurodegenerative disorder affecting over six million individuals worldwide (1). PD is characterized by the progressive loss of neurons throughout the peripheral autonomic and central nervous systems. Current diagnosis of PD is based on the presence of rest tremor, bradykinesia, rigidity and postural response abnormalities which are tightly associated with dopaminergic loss. The etiology of PD remains poorly understood, although aging, genetic and environmental factors have been identified as risk factors. Currently, only exercise has shown an effect on disease progression and no approved treatment targets the basic mechanism of the disease or its direct cause.
Clostridia are gram-negative obligate anaerobe bacteria that are prevalent in the environment. Several members of the Clostridium species produce highly potent toxins (2). Notably, C. tetani can produce Tetanus neurotoxin, the causative agent of tetanus (3, 4). In tetanus, the neurotoxin is internalized into signaling endosomes and transported retrogradely to the neuronal soma, interfering with the release of neurotransmitters, notably glycine and gamma-aminobutyric acid, blocking inhibitory impulses(5). Lacking inhibitory neurotransmission, motor neurons stimulation increases, producing rigidity, unopposed muscle contraction and spasm(6)
To protect from the severe risks associated with tetanus disease, the combined Tetanus and Diphtheria toxoid (TD) vaccine is routinely administered to infants, children and adolescents as part of the standard immunization programs(7, 8). Adults usually receive anti-tetanus booster vaccination upon clinical indication, when they present in clinic with a wound susceptible to be infected with C. tetani, and there is no record of vaccination in the last ten years (or five years in a dirty wound at high risk for contamination). In a serologic survey performed in the United States between 1988 and 1994, fully protective levels of anti-tetanus and anti-diphtheria antibodies were detected in 91% of individuals aged 6 to 11 years but in only 47% of individuals 20 years or older (9, 10). Interestingly, PD happens to be diagnosed at the late adult age, typically after 45, when tetanus antibody protection acquired from childhood and adolescence vaccination is no more protective.
Recent studies have revealed significant differences in the gut microbiota composition between patients with Parkinson’s Disease (PD) and healthy controls (11). Notably, alterations were observed for Clostridia species (12). C. tetani have been isolated in the feces from adult individuals (13), suggesting it might be a common host of the human gut. Given its potential to cause synaptic dysfunction, clostridium neurotoxin might play a role in the neurodegenerative process responsible for PD. If a Clostridium neurotoxin contributes to the pathogenesis of PD, an inverse correlation would be expected between the administration of the tetanus toxoid vaccine and the incidence of PD."
Written by
Bolt_Upright
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My husband had to get a tetanus shot because he got scratched by a rusty nail in an old piece of wood he found on our property. The nurse giving the shot did not want to give it to him because it was shortly after he had a covid vaccination. He did get the shot due to the dangers involved but right after that his symptoms were far worse. My initial thought was that maybe this was the result of extra stress on the immune system.
He does take B1 and is doing relatively well now and maybe it was just the stress of attempting to develop immunity to two things at once - I don't know
I went months on a B1 sweet-spot and have had worsening of symptoms, twice. I figure due to supplements working, I took breaks and reduced dose. healthunlocked.com/cure-par....
Extra stress caused by the immune system - Vaccines work by causing a strong inflammatory response, and that surely adds up when two are given close together.
Any improvements at all in his PD after the exacerbation subsided?
Yes he did have improvement about 4-6 weeks after that and now he is actually better than he was before. He has had acupuncture, craniosacral therapy, chiropractic treatments, and matrix repatterning. We see one practitioner who is trained in all of these. She is very focused on learning everything she can that might be helpful.
He is having stem cell infusions now and his walking and vision are improved. His tremors are somewhat improved but not gone. He has macular puckers in both eyes and the eye specialist wanted to do surgery on his eyes but he just had another appointment with the eye specialist and he does not think surgery is necessary for the time being. I do find myself wondering if the macular puckers could have developed due to changes to the eyes caused by Parkinsons. He got a macular pucker in one eye then a few years later one in the other eye. The eye doctor did cataract surgery on both eyes in 2018 because he had hopes that this would improve his vision but that surgery did not do much. The macular pucker happens due to less vitreous humor inside of the eye which can be more common as a person ages.
"Macular pucker, also known as epiretinal membrane (ERM) or cellophane maculopathy, is a rare eye condition that causes scar tissue to form on the macula, the center of the retina. The macula provides sharp, central vision for reading, driving, and seeing fine detail. Macular pucker can cause blurred and distorted central vision
Blurry or mildly distorted vision
Straight lines appearing wavy
Difficulty seeing fine detail and reading small print
You cannot focus perfectly even when wearing your glasses
Difficulty seeing in low light
My husband likes to read just a couple weeks ago he mentioned that it was easier for him to read now but it is important for him to have a lot of light when reading.
Brainstorming (my thoughts): The tetanus shot inhibits Clostridium infection in the body. It is reasonable to assume there are no antibodies in the gut and Clostridium could still be unrestrained in the gut. Therefore, it should be beneficial to take other probiolic to overpower Clostridium in the gut. More important make sure your probiolic does not contain Clostridium.
Googled: will Clostridium Butyricum cause Clostridium infection
Yes, some strains of Clostridium butyricum (CBM) are involved in infectious diseases. CBM 588 can improve colonization resistance against Clostridioides difficile (CDI) and reduce gut inflammation. CBM 588 can also modulate the gut microbiome and metabolic function.
CBM is one of the most commonly used probiotics and has been shown to be effective in many kinds of gastrointestinal disease, such as ulcerative colitis and enterohemorrhagic E. coli (EHEC) colitis. CBM can inhibit the transmission of antibiotic-resistant genes and maintain homeostasis of the gut.
However, some strains of C. butyricum are involved in infectious diseases. For example, case reports have noted the development of C. butyricum bacteremia in patients taking probiotics. Bacteremia caused by C. butyricum is a rare condition, and the prevalence, clinical features, and bacteriologic and genetic origins of the strains are unknown.
Also Googled: is Clostridium Butyricum a Butyrate producing bacteria.
Yes, Clostridium butyricum is a butyrate-producing bacterium that is found in the human gut. It has been used as a probiotic for decades and has been investigated for its potential to treat a variety of diseases.
C. butyricum is relatively common in the Clostridium genus, and most Firmicutes are butyrate-producing bacteria. Other common butyrate-producing bacteria include Ruminococcus, Eubacterium, and Coprococcus.
C. butyricum has the potential to alleviate a range of disorders such as inflammatory bowel disease (IBD), colitis, and obesity. It has also been shown to suppress Clostridioides difficile infection.
🌟👋👍Google search: what probiotic kills Clostridium, results:
Probiotics, or "good bacteria", are live microorganisms that can help prevent or treat Clostridium difficile (C. diff). Some probiotics that have been shown to be effective against C. diff include:
Lactobacillus GG: Reduces the three-week recurrence rate of C. diff, and patients report less abdominal cramps and diarrhea
Saccharomyces boulardii: Reduces pathogen adhesion, and lessens the inflammatory immune response
Lactobacillus acidophilus: Inhibits C. diff growth, and downregulates C. diff virulence genes
Other probiotics that have been used in clinical trials include: Lactobacillus plantarum 299vand Bifidobacterium lactis Bl-04.
Probiotics work by inhibiting harmful bacteria through producing bacteriocin. They can also support the gut microbiome to remain balanced
Recurrence of clinical symptoms (main outcome) was seen in 4 of 11 patients who received metronidazole in combination with L. plantarum 299v and in 6 of 9 treated with metronidazole in combination with placebo.
So, maybe 299v isn't the best defense against Clostridium.
This morning I took a 299v with my Probiotic and Inulin on empty stomach. My head was tingly with in a few minutes and it lasted for at least45 minutes. Something happened... Feel fine now... Maybe a little better...
"My husband had to get a tetanus shot because he got scratched by a rusty nail in an old piece of wood he found on our property. The nurse giving the shot did not want to give it to him because it was shortly after he had a covid vaccination. He did get the shot due to the dangers involved but right after that his symptoms were far worse. My initial thought was that maybe this was the result of extra stress on the immune system. "
In my case, it's been 7 months since my Covid vaccine (and 12 years since my last tetanus booster), but I'll mention that to the Dr. Thanks for the heads up.
Great find, Bolt. Note that the study covers factors in addition to Tetanus vaccination. Table 2 from the study shown, Positive numbers mean an increase in Parkinson symptoms; negative numbers a decrease. If you need to take a course of an antibiotic, avoid clindamycin. Also, "Interestingly, we also observed strong apposing effects for two laxative agents commonly used to treat constipation in PD patients. Macrogol (polyethylene glycol), was significantly associated with increased disease severity (+0.34, P<0.001), while ispaghula (Psyllium), a dietary fiber, was associated with decreased disease severity (−0.42, P=0.0004)."
The study is noted as not peer reviewed nor to be taken for medical direction. So doctors won't act on it.However it's a good glimmer of light.
We need researchers to build further, thorough research on this.
The good thing is that European and U.S. medical health organisations will have this same type of data. All they need to do is, extract it, join it up and analyse. No need for big pharma approval to demonstrate the correlation.
I believe my PD resulted from a Tetanus DTAP, shot as upon receiving the shot I was met with a strong metallic taste in my mouth. This resulted in a change in my health, as evidenced by my medical records over a number of years. My son also had the same shot prior to our trip to Egypt and now has symptoms and signs of MS. His health also changed following the shot with chronic gut issues. We were both perfectly healthy prior to our shots. The only thing I can say, is we both have slow progression of our situations.
I am so sorry to hear bout you and your son's reaction. I am not suggesting anybody get the shot, just sharing the info.
I am guessing you have heard about this MS treatment. I have been tracking it for quite some time: Hematopoietic stem-cell transplantation (HSCT). This is the treatment Selma Blair got. today.com/health/selma-blai...
Please let me know if you want more info on this. It is supposed to best for relapsing remitting, but I tracked a person that got it for secondary progressive once.
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