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Xtandi
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Medicare B not covering Keytruda
Since then, I have failed salvage radiation, ADT, Casodex, radiation to the left humerus (incipient fracture), Zytiga+prednisone,
Xtandi
, and full replacement of the left shoulder.
Since then, I have failed salvage radiation, ADT, Casodex, radiation to the left humerus (incipient fracture), Zytiga+prednisone,
Xtandi
, and full replacement of the left shoulder.
gvweller
in
Advanced Prostate Cancer
6 years ago
Xtandi and Severe abdominal cramps.
Anyone experience severe abdominal cramps with
Xtandi
? If so what are you doing to control cramps/pain. There are many reports of pain and abdominal cramps but what is causing it and what will help with it. No narcotic/opioid for pain. He is currently on no pain medications. Only takes Advil.
Anyone experience severe abdominal cramps with
Xtandi
? If so what are you doing to control cramps/pain. There are many reports of pain and abdominal cramps but what is causing it and what will help with it. No narcotic/opioid for pain. He is currently on no pain medications. Only takes Advil.
Daddysdaughter
in
Advanced Prostate Cancer
7 years ago
Why Resistance To Xtandi and Zytiga Develops
Looks like combination therapy is the way to go to delay resistance Gus http://www.sciencedirect.com/science/article/pii/S2214388215000247
Looks like combination therapy is the way to go to delay resistance Gus http://www.sciencedirect.com/science/article/pii/S2214388215000247
gusgold
in
Advanced Prostate Cancer
7 years ago
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The War on Cancer, & Stem-like Cancer Cells.
The big success stories of recent years - Zytiga &
Xtandi
- follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now
Xtandi
) or by starving AR of hormones (as with castration, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
The big success stories of recent years - Zytiga &
Xtandi
- follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now
Xtandi
) or by starving AR of hormones (as with castration, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Xtandi (Enzalutamide) & Drug-Drug Interaction.
Worth asking if dosages will be diluted by
Xtandi
. The Pharma attitude to liver enzymes, rather than inhibiting them, is to use ten times as much drug, say, on the basis that the liver will destroy 90%. But in the case of
Xtandi
, there seems to be a case for inhibiting excess production of CYP3A4.
Worth asking if dosages will be diluted by
Xtandi
. The Pharma attitude to liver enzymes, rather than inhibiting them, is to use ten times as much drug, say, on the basis that the liver will destroy 90%. But in the case of
Xtandi
, there seems to be a case for inhibiting excess production of CYP3A4.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Xtandi Lower Dose Work?
I have a question for those of you that had been on
Xtandi
and had significant side effects. My father began
Xtandi
and after the 3rd week we saw significant mood change, depression and forgetfulness. The MO recommend we lower the dose to 3 pills a day. Since then my father is back!
I have a question for those of you that had been on
Xtandi
and had significant side effects. My father began
Xtandi
and after the 3rd week we saw significant mood change, depression and forgetfulness. The MO recommend we lower the dose to 3 pills a day. Since then my father is back!
Daddysdaughter
in
Advanced Prostate Cancer
7 years ago
Finally, Real Promise' for Prostate Cancers With No Therapy20+-Month Improvement in Metastasis-Free Survival
The PROSPER trial employed the earlier-generation enzalutamide (
Xtandi
, Astellas/Pfizer), which is already approved for men who have metastatic prostate cancer.
The PROSPER trial employed the earlier-generation enzalutamide (
Xtandi
, Astellas/Pfizer), which is already approved for men who have metastatic prostate cancer.
Hidden
in
Advanced Prostate Cancer
6 years ago
How to Find a good pain management and/or Quality of life specialist for an advanced metastic prostate cancer patient
I believe it is the result of the side effects from the pain medication (50mcg/hr fentanyl patches and 4mg Hydromorphone tablets every 4 hours as needed) and
Xtandi
(4 40mg capsules every 4 hours as needed) which I started August 15.
I believe it is the result of the side effects from the pain medication (50mcg/hr fentanyl patches and 4mg Hydromorphone tablets every 4 hours as needed) and
Xtandi
(4 40mg capsules every 4 hours as needed) which I started August 15.
chascri
in
Advanced Prostate Cancer
7 years ago
New Guy Info
I will start taking the
Xtandi
in a few days and thought I might be able to relate my experience with it here to possibly help others. I am 69 years old and in good health other than having a incurable disease.
I will start taking the
Xtandi
in a few days and thought I might be able to relate my experience with it here to possibly help others. I am 69 years old and in good health other than having a incurable disease.
steveebear
in
Advanced Prostate Cancer
7 years ago
Xtandi after Zytiga
Has anyone had any luck with
Xtandi
after Zytiga?
Has anyone had any luck with
Xtandi
after Zytiga?
wrando
in
Advanced Prostate Cancer
7 years ago
Xtandi dosage
Started on
xtandi
10 weeks ago and PSA has reduced from 30 to 5 . I have been taking the tablets one 4 times a day but now I realise from other posts here that I should have been taking the 160 mgs all at once.
Started on
xtandi
10 weeks ago and PSA has reduced from 30 to 5 . I have been taking the tablets one 4 times a day but now I realise from other posts here that I should have been taking the 160 mgs all at once.
Hidden
in
Advanced Prostate Cancer
7 years ago
CVS in talks to buy Aetna
Now, it makes sense why I was denied
Xtandi
. And now, JoelT's post from last year, about CVS, is coming to fruition. This is a sad state of affairs, in my opinion. Joe
Now, it makes sense why I was denied
Xtandi
. And now, JoelT's post from last year, about CVS, is coming to fruition. This is a sad state of affairs, in my opinion. Joe
Hidden
in
Advanced Prostate Cancer
7 years ago
Abi to Enzi no cross resistance yet
Changed to
xtandi
. and after four months went to 5.64 . Hope Provenge is doing it’s thing in the microenvironment. Alkaline phosphatase down 60. No pain in almost 8 years.
Changed to
xtandi
. and after four months went to 5.64 . Hope Provenge is doing it’s thing in the microenvironment. Alkaline phosphatase down 60. No pain in almost 8 years.
Drcrunch
in
Advanced Prostate Cancer
7 years ago
Dx 3/2017 PSA 363 with bone mets
The pain is back in his hips - side effects of
Xtandi
or mets?? Don't know. He will have a PET scan soon. Dr is getting that scheduled now. Also getting Procrit shots every week Xgeva every 4 weeks and Zoladex every 12 weeks.
The pain is back in his hips - side effects of
Xtandi
or mets?? Don't know. He will have a PET scan soon. Dr is getting that scheduled now. Also getting Procrit shots every week Xgeva every 4 weeks and Zoladex every 12 weeks.
CaregiverWife
in
Advanced Prostate Cancer
7 years ago
Xtandi update
I started
Xtandi
August 15, PSA 5.35. My PSA on October 13 was down to 2.04. So it seems to be working. Side effects have gotten worse , extreme fatigue, mild nausea, severe bloating and gas and shortness of breath on exertion.
I started
Xtandi
August 15, PSA 5.35. My PSA on October 13 was down to 2.04. So it seems to be working. Side effects have gotten worse , extreme fatigue, mild nausea, severe bloating and gas and shortness of breath on exertion.
chascri
in
Advanced Prostate Cancer
7 years ago
Lupron and arrhythmias
He started
Xtandi
September 26th. Prior to
Xtandi
he had an episode of chest pain that he was admitted for. My father has CAD with 9 stents but every test including chest CT, ECHO, stress test, multiple EKG and cardiac enzymes were all NEGATIVE.
He started
Xtandi
September 26th. Prior to
Xtandi
he had an episode of chest pain that he was admitted for. My father has CAD with 9 stents but every test including chest CT, ECHO, stress test, multiple EKG and cardiac enzymes were all NEGATIVE.
Daddysdaughter
in
Advanced Prostate Cancer
7 years ago
Leu 177 and Advice
Im about to start some leutetium 177 psma therapy here in australia and wondered what people thought about combining it with zytiga or
xtandi
. Im now on xgeva. Ive used lots of natural supps, juice,meditation etc but my PSA is around 120 now and I have mets. Just wanting thoughts.
Im about to start some leutetium 177 psma therapy here in australia and wondered what people thought about combining it with zytiga or
xtandi
. Im now on xgeva. Ive used lots of natural supps, juice,meditation etc but my PSA is around 120 now and I have mets. Just wanting thoughts.
jonnycrouch
in
Advanced Prostate Cancer
7 years ago
Xtandi experiences
Just received the call an hour ago , Doctor wants to put me on
Xtandi
immediately and see me in a month. Been anticipating this call; now want learn what I should expect over the course of the next few months from those that have been down this road
Just received the call an hour ago , Doctor wants to put me on
Xtandi
immediately and see me in a month. Been anticipating this call; now want learn what I should expect over the course of the next few months from those that have been down this road
AnderB
in
Advanced Prostate Cancer
7 years ago
Xtandi Experiment
I just came into 11 bottles of
Xtandi
from a family whose father died. I plan on doing
Xtandi
BAT. My T level is 900 + or -...So it is
Xtandi
on for 3 months then
Xtandi
off for 3 months...
Xtandi
BAT
I just came into 11 bottles of
Xtandi
from a family whose father died. I plan on doing
Xtandi
BAT. My T level is 900 + or -...So it is
Xtandi
on for 3 months then
Xtandi
off for 3 months...
Xtandi
BAT
gusgold
in
Advanced Prostate Cancer
7 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
The study enrolled 50 patients who were no longer responding to standard treatments, including docetaxel (Taxotere), abiraterone acetate (Zytiga), enzalutamide (
Xtandi
), or cabazitaxel (Jevtana). Genomic sequencing was performed on tumor biopsies as a requirement of the study.
The study enrolled 50 patients who were no longer responding to standard treatments, including docetaxel (Taxotere), abiraterone acetate (Zytiga), enzalutamide (
Xtandi
), or cabazitaxel (Jevtana). Genomic sequencing was performed on tumor biopsies as a requirement of the study.
JLS1
in
Advanced Prostate Cancer
6 years ago
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