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Atorvastatin
I had been resisting my GPs' calls to take statins for some years having pointed out to them that although they were saying a total cholesterol level around 6 was too high the ratio of HDL to LDL was good. About eighteen months ago I acquiesceded and started taking Atorvastatin. However, l was hospitalised
I had been resisting my GPs' calls to take statins for some years having pointed out to them that although they were saying a total cholesterol level around 6 was too high the ratio of HDL to LDL was good. About eighteen months ago I acquiesceded and started taking Atorvastatin. However, l was hospitalised
Roland_Burdess
in
British Heart Foundation
10 months ago
terrible metalic taste in my mouth ALL the time!
I’m now into my second year of PMR, I’m on 5mgs of Prednisone and 20mgs of somac a day, 50mgs of Endep at night. I don’t think I have changed anything in my diet etc but I have a terrible metallic taste in my mouth constantly, nothing cuts through it, I’ve tried biting a lime and nothing, whatever
I’m now into my second year of PMR, I’m on 5mgs of Prednisone and 20mgs of somac a day, 50mgs of Endep at night. I don’t think I have changed anything in my diet etc but I have a terrible metallic taste in my mouth constantly, nothing cuts through it, I’ve tried biting a lime and nothing, whatever
Heidiypi1
in
PMRGCAuk
6 months ago
Aspen Neuroscience to Present at International Society for Cell & Gene Therapy (ISCT) Annual Meeting
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
Farooqji
in
Cure Parkinson's
6 days ago
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Gene therapy
I know it's not PD but it is a neurological condition and sounds like a hopeful developmentUK toddler has hearing restored in world first gene therapy trial https://www.theguardian.com/science/article/2024/may/09/uk-toddler-has-hearing-restored-in-world-first-gene-therapy-trial?CMP=share_btn_url
I know it's not PD but it is a neurological condition and sounds like a hopeful developmentUK toddler has hearing restored in world first gene therapy trial https://www.theguardian.com/science/article/2024/may/09/uk-toddler-has-hearing-restored-in-world-first-gene-therapy-trial?CMP=share_btn_url
WinnieThePoo
in
Cure Parkinson's
27 days ago
Bayer and AskBio report data from Parkinson’s disease therapy trial
The bilateral infusions of AB-1005 were well tolerated, without any SAEs linked to the gene therapy or contrast agent. AskBio Parkinson’s and MSA Scientific chair Krystof Bankiewicz said: “These early findings are encouraging and show AB-1005 to be well tolerated in this study in patients with mild
The bilateral infusions of AB-1005 were well tolerated, without any SAEs linked to the gene therapy or contrast agent. AskBio Parkinson’s and MSA Scientific chair Krystof Bankiewicz said: “These early findings are encouraging and show AB-1005 to be well tolerated in this study in patients with mild
Farooqji
in
Cure Parkinson's
2 months ago
CRISPR 13 (what? you thought I abandoned CRISPR?): very promising proof of concept - Targeting HOXB13 in mPCa by CRISPR/Cas13d- nanoparticle
And people thought it was undruggable....they have already filed for a patent 😲 Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
And people thought it was undruggable....they have already filed for a patent 😲 Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
Maxone73
in
Advanced Prostate Cancer
2 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
2 months ago
Swanbio gene therapy study
Anyone know how this study is going? I did a google search and there was something posted a few days ago but you had to buy the report. $500. I’m very interested but information seems hard to come by. It doesn’t sound like it would repair damage but stop or slow the disease. I wonder if it would eliminate
Anyone know how this study is going? I did a google search and there was something posted a few days ago but you had to buy the report. $500. I’m very interested but information seems hard to come by. It doesn’t sound like it would repair damage but stop or slow the disease. I wonder if it would eliminate
Golfdog3
in
AMN EASIER
3 months ago
Gene therapy
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
Farooqji
in
Cure Parkinson's
4 months ago
Let's enjoy some predictions: cell and gene therapy in 2024
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
Maxone73
in
Advanced Prostate Cancer
4 months ago
Secondary Cancers after CAR-T Cell Therapy
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
Jm954
Administrator
in
CLL Support
4 months ago
Neurological Disorders: How Regenerative Medicines Help in Treating Nervous System Diseases
In this insightful discussion, the revolutionary field of regenerative medicine and its profound impact on treating neurological disorders are being discussed. Discover cutting-edge techniques such as stem cell therapy, gene therapy, and surgical innovations that are reshaping the landscape of neurology
In this insightful discussion, the revolutionary field of regenerative medicine and its profound impact on treating neurological disorders are being discussed. Discover cutting-edge techniques such as stem cell therapy, gene therapy, and surgical innovations that are reshaping the landscape of neurology
Farooqji
in
Cure Parkinson's
5 months ago
AB-1005
By posting this I am not necessarily advocating this treatment just trying to find out more information on how it is made and how it is administered [u]Gene therapy AB-1005 found safe in Phase 1b Parkinson’s trial[/u] https://parkinsonsnewstoday.com/news/gene-therapy-ab-1005-safe-phase-1b-trial/?utm_source
By posting this I am not necessarily advocating this treatment just trying to find out more information on how it is made and how it is administered [u]Gene therapy AB-1005 found safe in Phase 1b Parkinson’s trial[/u] https://parkinsonsnewstoday.com/news/gene-therapy-ab-1005-safe-phase-1b-trial/?utm_source
Boscoejean
in
Cure Parkinson's
5 months ago
AAV-GAD Gene Therapy
Did anyone hear of AAV-GAD gene therapy? I have a chance to get into a phase 1/2 trial, but information is somewhat limited. The original developing company went bankrupt, and a new company bought the rights to the therapy. The trails are being held at reputable sites like Yale, Columbia , and Cornell
Did anyone hear of AAV-GAD gene therapy? I have a chance to get into a phase 1/2 trial, but information is somewhat limited. The original developing company went bankrupt, and a new company bought the rights to the therapy. The trails are being held at reputable sites like Yale, Columbia , and Cornell
JohnP65
in
Cure Parkinson's
5 months ago
FDA Investigating 'Serious Risk' of Malignancy After CAR-T Therapy - Applies to all approved therapies, but benefits still outweigh risks
From MedPage Today, by Charles Bankhead, Senior Editor, MedPage Today November 28, 2023, Last Updated November 29, 2023. Posted FYI without comment: [i]
FDA Investigating 'Serious Risk' of Malignancy After CAR-T Therapy - Applies to all approved therapies, but benefits still outweigh risks, agency
From MedPage Today, by Charles Bankhead, Senior Editor, MedPage Today November 28, 2023, Last Updated November 29, 2023. Posted FYI without comment: [i]
FDA Investigating 'Serious Risk' of Malignancy After CAR-T Therapy - Applies to all approved therapies, but benefits still outweigh risks, agency
cujoe
in
CLL Support
6 months ago
Genetic therapy: for solid malignancy hopefully soon
ok, I post them also because they are fellow Italians! But the platform is very promising even if clinical use has been approved only for glioma and glioblastoma at the moment. But there are clinical trials going on for solid tumors, prostate included. https://www.genenta.com/wp-content/uploads/2021
ok, I post them also because they are fellow Italians! But the platform is very promising even if clinical use has been approved only for glioma and glioblastoma at the moment. But there are clinical trials going on for solid tumors, prostate included. https://www.genenta.com/wp-content/uploads/2021
Maxone73
in
Advanced Prostate Cancer
6 months ago
Replace or reorganize neurons
Can someone explain :Does the parkinson's glove therapy assume we don't have a loss of Dopa. Neurons but they just need to be reorganized. Via vibration Where gene therapy assume we have a loss of Neurons that need to be replaced ? Which is it, replace or reorganize?
Can someone explain :Does the parkinson's glove therapy assume we don't have a loss of Dopa. Neurons but they just need to be reorganized. Via vibration Where gene therapy assume we have a loss of Neurons that need to be replaced ? Which is it, replace or reorganize?
bigl62
in
Cure Parkinson's
7 months ago
Targeted Gene Therapy for Symptom Relief in Parkinson’s Disease
Very early, still a looooong way out, and results were only in animal models, but something to keep an eye on. https://www.brainpost.co/weekly-brainpost/2023/11/7/targeted-gene-therapy-for-symptom-relief-in-parkinsons-disease
Very early, still a looooong way out, and results were only in animal models, but something to keep an eye on. https://www.brainpost.co/weekly-brainpost/2023/11/7/targeted-gene-therapy-for-symptom-relief-in-parkinsons-disease
Neurosmith
in
Cure Parkinson's
7 months ago
Megan's Update from Mission: Cure
Dear friend, I just got back from New Delhi, India, where the International Association of Pancreatology invited me to speak to a few hundred pancreas researchers and doctors, and I wanted to share some updates. 💬
Pancreas 2023 Conference
This was the first time that a patient advocacy group
Dear friend, I just got back from New Delhi, India, where the International Association of Pancreatology invited me to speak to a few hundred pancreas researchers and doctors, and I wanted to share some updates. 💬
Pancreas 2023 Conference
This was the first time that a patient advocacy group
Skye_MC
Administrator
in
Chronic Pancreatitis Support
8 months ago
Lanzoprazole and low B12
Hi guys I am worried and I don’t know if I am worried about nothing. In a nutshell, in 2018 hubby starts heart meds and has done so ever since. One of which is landoprazole 15mg every day. Purpose to protect his stomach from the potential harm from taking 75mg asprin to thin his blood. A couple
Hi guys I am worried and I don’t know if I am worried about nothing. In a nutshell, in 2018 hubby starts heart meds and has done so ever since. One of which is landoprazole 15mg every day. Purpose to protect his stomach from the potential harm from taking 75mg asprin to thin his blood. A couple
Wwwdot
in
Pernicious Anaemia Society
11 months ago
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