For the last week, I’ve been wearing a 7mg nicotine patch with amazing results. Almost every night since I’ve slept through the night. My symptoms have improved, I have a much better sense of wellbeing.
Nicotine has been known for years for its medicinal properties. Eggplant has the second most nicotine containing plant, tomatoes are the 3rd.
Nicotine has been demonized for years, you know who didn’t die from Covid, smokers. Covid attacked same receptors that nicotine uses. God put nicotine on this earth and put receptors in your cell so you can use it. There’s a 2015 study, where Harvards scientist tried to get mice addicted to nicotine. They could get mice, addicted to sugar, alcohol, and other drugs. They couldn’t get the mice addicted to nicotine without the added pyrazines. It’s well-known that the tobacco companies started to add them to nicotine to make them more addictive in the 1970s. They also added arsenic and sugar?
What would be the purpose of adding arsenic and sugar other than to create and feed cancer? 1994, all the tobacco industry, heads testified before Congress, the nicotine was not addictive. They have not been sued. It’s also when they started to demonize nicotine, not tobacco, nicotine. As we well know, the government is in bed with the pharmaceutical companies. Those companies know the medicinal properties of nicotine. They can’t make billions on treating us with artificial man-made chemicals if All we have to do issues a cheap, natural medicinal chemical that God put on this earth. Similar to marijuana. The demonized marijuana because they knew it worked. When I was a kid I didn’t know the difference between marijuana and cocaine . It’s also incredibly safe. I’m going to see Willie Nelson in Vegas next month. He’s 90 and going Strong . It’s been well known that smokers have huge decreased risks from Parkinson’s.
Do you know what’s also interesting? Biden just announced that by 2030, he’s getting rid of nicotine products? That’s a heckuva coincidence.
I haven’t felt at all addicted to the nicotine patches. After I started wearing them, my 12-year-old daughter asked if I had to went to the doctor because I was walking so good. I wanted to cry. Do you know what is addictive??? carbidopa levodopa!!! Early in my Parkinson’s diagnosis, I felt better when I didn’t take the medicine. So I stopped cold turkey. I know how stupid that was. I nearly died of neuro malignant syndrome.
Do yourself a favor and go buy a 7 mg nicotine patch. To start with, especially if you are sensitive, you can cut the patch into thirds or half. See how you feel?
Nicotine is a normal ingredient in the diet, and is present in many vegetables and foodstuffs.
It appears to have an important role in protecting against neurodegenerative and auto-immune disease, for some genotypes if not all. Those who eat more nicotine-containing vegetables are shown to be less vulnerable to Parkinson’s, for example.
Nicotine is an effective therapy for Parkinson’s patients and others.
Nicotine has no association with cancer. It does not affect it or induce or assist it in any way in humans. See NICE PH45 for example.
No clinical study exists that demonstrates pure nicotine has any negative health impact for humans. For other lifeforms, this does not apply. Many of the things we consider nutrients are toxic for other species, and we consume ‘insecticides’ as normal because they are beneficial for us. It is entirely normal for us to consume the ‘insecticides’ trimethylxanthine or methyl pyridine [1], for example, because they are good for us. Indeed labelling some of our foods as insecticides indicates the disingenuous nature of the argument. Having a scary chemical name like d-alpha tocopherol does not make something poisonous [2].
It is clinically impossible to demonstrate any potential for vaping to ‘addict’ never-consumers of tobacco. There is at least $10 million waiting for the first researcher to demonstrate it; they are trying all the time and have been for years. It can’t be done. Ex-smokers are dependent on nicotine because that is what smoking it with tobacco does.
Dependence on nicotine requires a tobacco delivery vehicle. There is no evidence anywhere to refute that. A clinical trial that demonstrates dependence on nicotine in never-smokers does not exist - but nicotine is being administered to never-smokers in CTs every day. Ethics panel approvals for this are routine - nicotine is considered harmless, or the current level of research with never-smokers could not exist.
You cannot become dependent on nicotine outside of being a tobacco consumer - the other compounds in tobacco boost, potentiate and synergise nicotine, and increase its potential for dependence exponentially. Ethics committees know very well indeed that you can shovel it down the throat of never-smokers for 6 months and it will have no effect at all except act as a therapeutic for the neurodegenerative or auto-immune condition it is being tested on.
If it does have any other effect, it will be to reduce blood pressure in the hypertensive and improve cognitive functionality for some.
All the arguments against nicotine turn out to be fraudulent in some way when examined - somebody is making money by convincing you it is harmful. As an example, they repeat that nicotine harms the CV system, in some way. However, the world authority on long-term pure nicotine administration to never-smokers, Dr Paul Newhouse, states clearly that the only chronic effect he can locate unrelated to treating patients with assorted medical conditions is that nicotine lowers the blood pressure slightly.
You might want to read that last sentence again. It’s made by the person with the largest database on pure nicotine clinical trial effects in the world, when administered to never-smokers. Nobody else has access to this size of data resource.
Smoking has all kinds of harmful effects. They are restricted to smoking, not consumption of individual compounds present without smoke.
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"Among 163 participants, 101 were assessed for the primary end point. Mean worsening of Total UPDRS was 3.5 in the placebo versus 6.0 in the nicotine group ... Dropout was mainly because of early treatment discontinuation or adverse events. Cutaneous adverse effects at the patch application site were common"
In other words, Parkinson's progressed more rapidly in the nicotine group, although those results were not stat sig.
Individual variation is also possible - There are many different causes of Parkinson's disease. If it is working for you it is not my intention to throw cold water on the benefit that you experience.
I have to say, I titrate 1.5 mg nicotine in my water daily 2 ltr bottle. I prefer to get addicted to hydration over patches, vaping or smoking. Water is good. Now for this study the flaw is in the group selected - those with PD. Nicotine may be best used in the prodromal phase because it is at this point the neurogenisus benefits are relavent. Product is inexpensive nicbase.com/nicotine-liquid...
It does help me maintain focus. Now regarding MJFF, I would expect no other results as I suspect they wish to preserve there relationships with Big Pharma. Nicotine is a Big Pharma killer is it has a benefit. Nicotine is not the demon regardless if it is addictive or not. If it is addictive, I will just drink more water. I look at it no different than coffee. I definately want to hear from others that are using and and at what phase are they in the PD spectrum.
Why would prodromal phase PD give the opposite result from early stage PD patients, who were the subjects of the study?
MDs in general do tend to be hostile towards supplements, but that fact alone is not sufficient to invalidate a study. This study was undertaken by a group out of Marburg Germany. No reason to specifically bash MJFF.
well in the prodromal phase damage is to a degree and when you are diagnoised with PD damage is done. One is stopping the progression of damage and the other is reversing the damage - two very different processes. The very sad fact is prodromal PD is not treated by traditional medicine as expressed here on this site. It is my mission to establish therapies that do slow or stop the progression and allow the body to do its work of healing.
Progression continues after diagnosis. Stopping progression at any time is of great value. In the study at hand, nicotine treated patients progressed more rapidly than placebo patients. No reason to expect any difference in prodromal patients.
Western allopathic medicine does not treat disease progression at any stage of Parkinson's at this time.
Thanks for sharing this. If it works it works regardless of how people feel about it. I'm so happy for anyone who has any relief of symptoms. I'll keep this in mind for the future. I just started seeing a new Dr .who is helping me tremendously and thinks out of the box. I'll mention this to him.
He's a Osteopathic Dr. who does hands on manipulation and craniosacral work.He is focusing on pulling toxins out of my body that he thinks is contributing to advancing Parkinsons.
A good Dr.will try to find the underlying cause or anything contributing to worsening symptoms.
I agree with much of what you said about nicotine and its health potentials as well as the benefit you are reporting re your symptoms and wellbeing, but you said the following :
' Nicotine has been demonized for years, you know who didn’t die from Covid, smokers. '
This is completely wrong and has been repeated in a video available on YouTube and it is simply wrong as are other quotes from that video! The following 2023 meta analysis of multiple studies clearly shows the fallacy of this statement and weakens your testimonial about the benefit of nicotine :
' Overall, the meta-analysis revealed that smokers were 1.4 times more likely to have severe symptoms of COVID-19 and were 2.4 times more likely to be admitted to an intensive care unit (ICU), need medical ventilation, or die compared to non-smokers. While the above study found that smokers were more likely to have severe symptoms of COVID-19, a second meta-analysis by Patanavanich and Glantz (2020) demonstrated a likelihood of COVID-19 disease progression with smoking. This study included data available from 19 peer-reviewed papers (China (16), Korea (1), and the United States (U.S.) (2)) that were accessible from PubMed on April 6, 2020 [29]. This meta-analysis included a total of 11,590 individuals among which 731 COVID-19 patients (6.3%) had a history of smoking. Out of these smokers, 29.8% demonstrated disease progression as compared to 17.6% of non-smokers that experienced disease progression. The authors concluded that patients who are smokers were significantly more likely to experience disease progression and severe COVID-19 infection compared to nonsmokers (OR = 1.91; 95% CI: 1.42–2.59). '
Please do not perpetuate this straight up lie as it has no scientific basis in fact.
Art, I appreciate the info. How does a meta analysis for the likelihood of getting Covid? is there a particular study comparing non smokers to non smokers? It says that 6.3% of the people who they studied got Covid. What is the average of the population that smokes? In the United States it’s around 11%.. The study was mostly in China and Korea where 30% of the population smoke. Why is only 6.3 of the population getting Covid? If you think about it, you made my argument for me.
I’m just asking? Studies can manipulate the data. I’m not trying to get an argument, but I want to know your explanation?
Of course, the people who got Covid, probably had a worse outcome, because the damage to the lungs . But what about the people who never got it in the first place. I work with about 15 smokers. Everyone else got Covid except for them. I’ve had it three times???
Why did they base the study in china? Was there not enough studies in the United States? Do you honestly believe they tell the truth? Most of the studies were in China where info is suspect at best . Why would you be study in a country like China? Why not have a study United States? What is the study in United States? I trust science when it doesn’t follow the money. Science nowadays follows the money.
This is not an individual study, it is a meta analysis of multiple studies which all found that the outcome for smokers, including death was worse for smokers compared to non smokers. I saw the video that this quote came from and he used a mixture of truth and lies to put together a plausible argument for the use of nicotine as the treatment for Covid-19, plausible until you actually fact check his arguments. The following multi hospital randomized double blind placebo controlled trial (RCT) involving 218 participants, clearly shows that nicotine patches were similar to placebo in terms of their effect at reducing Covid-19 symptoms and death :
' Between November 6th 2020, and April 2nd 2021, 220 patients were randomized from 18 active recruiting centers. After excluding 2 patients who withdrew consent, 218 patients (152 [70%] men) were included in the analysis: 106 patients to the nicotine group and 112 to the placebo group. Day-28 mortality did not differ between the two groups (30 [28%] of 106 patients in the nicotine group vs 31 [28%] of 112 patients in the placebo group; odds ratio 1.03 [95% confidence interval, CI 0.57–1.87]; p = 0.46). The median number of day-28 ventilator-free days was 0 (IQR 0–14) in the nicotine group and 0 (0–13) in the placebo group (with a difference estimate between the medians of 0 [95% CI -3–7]). Adverse events likely related to nicotine were rare (3%) and similar between the two groups. '
They have seen similar studies in humans using melatonin in Covid-19 pneumonia patients on ventilators (late stage disease) and melatonin decreased symptoms, length of time on the ventilator, length of hospital stay and significantly increased survival, making it a far superior choice to placebo and or nicotine. I have already written about this at length on the HU forum.
I don't know where he gathered his supposed facts from, but he is 100% wrong about smokers and Covid-19! He has a couple of other quotes in that video that are also wrong. I am not trying to detract from your results of one week, but I can't let that misrepresentation pass without rebuttal.
Isn’t that study with people who already have Covid? I’m not saying it’s a treatment for Covid, but it’s clearly obvious that it had some protection if you smoke before getting Covid. You never answered my question why did all the studies come out of China not the United States? They make billionaires disappear in China if they go against the narrative. How do you explain that only 6.3% of the population was hospitalized were smokers 30% of the population smoked. That other study is quite small 218.? They literally gave billions of doses of the vaccine but they have a study of 218? I don’t believe in science when science follows the money. I don’t know if what I felt was placebo effect, it very well may be. But you have to answer why is only 6.3% of the population hospitalized with Covid and 30% of the population smoke? Is there not enough studies done in the United States? I know meta analysis is. It’s a study that studies other studies. Why based all those studies in China? My father in law was a perfectly health 66 year old before the vaccine. He got the vax and now he is dead.
That same father-in-law was an engineer. He works in multiple car companies, crashing cars. do you know what the companies would do when they found fault in their vehicles? They didn’t say anything. is there other studies more than 218 that showed benefits? They may just leave that out of the conversation because it’s not beneficial.
I'm going to repeat the quote from what you originally wrote that I am arguing against:
' Nicotine has been demonized for years, you know who didn’t die from Covid, smokers. '
This sentence implies smokers don't die from Covid-19 and that is simply not true because smokers die from Covid-19 as the meta analysis I linked to above proves. This is what I am arguing about, not whatever else you think I meant.
Reread the bold quote from the meta analysis that I linked to above. It clearly shows that smokers do worse from Covid-19 than non smokers including increased death rate.
I shouldn’t have made such a blanket statement. Why not answer my question? What about the 24% of people that never got hospitalized? How many of those people could’ve died? I apologize, but I think I’m correct. You say another way. You were five times less likely to be hospitalized if you smoked compared to regular population? Correct?
I don't know whether your last sentence is correct or not. Whether you are correct or not, the statement that I quoted is wrong and that is the point I was making, nothing more.
I have always looked at Covid-19 in terms of treating it with melatonin or other alternatives such as colloidal silver, hesperidin, X-Lear Nasal Spray or lysine etc. I have not looked at it in terms of percentage of people who get it or don't get it, just in terms of people who got it and what they can do to help get through it without dying. My intent is to offer a potential treatment option. The percentages you are asking me for, I don't have because I have never looked at covid in those terms, but it seems that many of covid statistics are based on hospitalizations where it is probably easier to conduct studies in a somewhat controlled environment.
I believe nicotine has health value and there is very limited anecdotal evidence to suggest it may help with long covid, but that was not what I was arguing. I was arguing against this statement which is 100% wrong :
' Nicotine has been demonized for years, you know who didn’t die from Covid, smokers. '
Is it possible that nicotine can prevent Covid-19? I don't know the answer to that question and I don't think the science is there yet to answer that question, but I wouldn't bet my life on it at this point in time.
you’re a good guy. I appreciate your input I believe you don’t even have Parkinson’s.? Pretty noble of you to help us out? I just believe science is failing with a lot of long-term chronic illnesses. My brother has Crohn’s disease and my mother had MS. Modern medicine didn’t really help either one of them. Your melatonin has really helped me a lot. MJF noble to try to cure it, it has failed and failed miserably. What makes me mad is that they are only looking at curing it with man-made chemical that they can make billions off of. Why not study all things that could possibly benefit. Like melatonin? I’m not saying for anyone to take up smoking. I just think it’s pretty obvious. It can have some great health benefits, especially Parkinsons. Thank you.
I agree on the science which generally moves at a glacial pace and is often looking at symptom relief as opposed to an actual cure. While that is helpful, a cure is forever?
If you have time, look into low dose naltrexone (LDN) for your brother as it significantly helps some people with Crohn's and other digestive issues. It is slow and gentle for those that it helps. It has a very good safety profile.
I still agree on the health potential of nicotine, but its association with smoking is so strong and I think overall that association works against productive nicotine research. I also agree that nicotine may likely not be addictive on its own in non smokers. I hope some studies using it in people with PD are done soon. It would be nice to have another option to choose from. Hopefully you update on your nicotine experience as you go because I'm sure interest will be high if your experience continues as positive.
I've been working on a new angle for melatonin over the past year and a half that has produced very interesting results which I may write about on this forum soon, but I need to gather more information first.
Don't waste your time with him. I don't know who you are, other than a 38yroldmale, but something tells me you will change the world. Have you tried keto with patch?
Amen....Out of curiosity how do you feel about I v e r m e c t i n, you know the horse de-wormer and h y d r o x y c h l o r o q u i n e, the fish tank cleaner?
I think that ALS patients would be interested in a trial for N i c o t i n e. If it has improved my husbands gait, stability, agility and balance for Parkinson's, why not.... Some people have nothing to lose. You know when they tell cancer patients you have 3 months to live but don't try any alternative medicine, whatever you do.
I would agree because I find when I smoke my Pipe. My mind clears and the fog goes away, I am also more steady on my feet. I have ready studies on the benefits from nicotine on slowing Parkinson's, Alzheimer's...
I have read your other posts as well. How has the nicotine patch helped your gait? Are you still using the Wellred helmet? Trying to find help for rigid dominant PWP with trouble walking/stiffness. Thanks for sharing.
I just realized that maybe some of the benefit was actually caused by Glynac. You need to for sure get your husband this supplement. NAC orally is a supplement, intervenous it’s a prescription. Quietly, the pharmaceuticals tried to ban it as a supplement. it caused quite an uproar, especially because there has been no harm shown ever. It’s because it works. Don’t know the dosage, but the study that I refer to in my other post. Approximately 8 g of both. For an 80 kg person. That’s a huge dose NAC, I don’t know if that would be healthy to go long-term. I am 190 lbs. I usually supplement somewhere between 2 to 3 g of NAC every single day. I really started to feel good when I got about 10 g gylcine. Be careful because Gylcine can make you very tired.
I walk faster, less hesitation, a more natural gait. I’d be happy to discuss further if you want to PM me. I enjoy it.
yes I do the well red helmet every other day with the nasal attachment. Have a cold laser that is very expensive that I do the other day. I went to a chiropractor a couple years ago, where he pointed the cold laser my head. I literally noticed after I was done, I could smell better. it makes sense because the laser like the light stimulates mitochondria. Good luck.
Could you tell me where you purchased the red light helmet? My husband has severe dementia already? Could it possible help him? He has had PD since 2015 which does not seem that long to be so advanced. He is 75.
HI. WAS VERY INTERESTED IN YOUR ARTICLE RE NICOTINE. WHAT IS YOUR REGIMEN ON ALL MEDICATION? I TOTALLY AGREE WITH YOUR TAKE ON 'BIG PHRMA' AND AM AWARE OF THE PITFALLS WITH C/L.THANK YOU IN ADVANCE
This study was partially funded by MJFF for a one year test of nicotine patch in PwP and was not helpful for people with PD in the early disease stages :
' Among 163 participants, 101 were assessed for the primary end point. Mean worsening of Total UPDRS was 3.5 in the placebo versus 6.0 in the nicotine group (HL-difference with 95% CI: –3 [–6 to 0], P=0.06). For the first secondary end point, analysis of 138 participants showed a mean worsening of 5.4 in the placebo versus 9.1 in the nicotine group (HL-difference with 95% CI: –4 [–7 to –1]). Dropout was mainly because of early treatment discontinuation or adverse events. Cutaneous adverse effects at the patch application site were common. In all, 34.6% of participants initiated dopaminergic therapy during participation. '
It sounded like the treatment group did not do as well as placebo.
Thanks for the food for thought. These spirited discussions are a reason I like this group so much. I never get these well-intentioned, passionate, outside the box thinking at the doctor's office. It motivates me to do research that I would have never done to dig deeper. I then adjust my regimen with more purpose. Appreciate the effort and camaraderie. Glad you are getting improvements
What I'm getting from this discussion is that nicotine does not equal smoking. I believe that is what Art and you are both saying. Although you muddied it a bit with the smokers statement, and I think that's where things got a little confused. But in my case, I was a smoker for more than half my life (march 7th made 14 years since I quit). So when I read a while back that smokers were less likely to get PD, I was baffled. I even considered briefly that maybe I should pick it back up! Anyway, I see totally what you are saying, that smoking is not the same as getting nicotine in your system, and that it binds to the same receptors as maybe COVID would, and maybe it is beneficial for PD for the same reason. I'm wondering whether a simple study with the nicotine gum might be useful. For me, the worst symptoms are tremor and constipation ... I'm actually considering ayurveda at the moment, and definitely want my lifestyle to change for the better. Us humans can be stubborn, and usually it takes a serious illness for most of us to make a meaningful change.
Amen. Husband has been able to work by chewing one piece of nicotine gum a day. Brain fog lifts, tremor stops, balance improves, sight improves, concentration improves, personality returns, energy boost, but calm. Sounds like a miracle to me...A neuro and a GP admitted that there was scientific evidence to support...I guess they just didn't want to share?
Hi, he takes one 4mg piece of gum when he goes to work...to stay alert when driving and working. He has a public speaking job which is very challenging. He is on Keto with intermittent fasting. So empty stomach all day, eats dinner at night. Sometimes he needs a second piece of gum in the afternoon because his work schedule varies. It's kind of a rescue med. Acts right away. He still passes out when he gets home, but it gets him through the day and he is able to earn a living which we didn't think was possible. My only regret is that we didn't know about this earlier in his disease process. I think he could have had a decent life for 10 years instead of constant suffering. The fact that a GP and a Neuro admitted that there is evidence to support use for Parkinson's makes my blood boil. I guess they just didn't feel the need to mention this.
I was looking at the recent news someone had kindly posted about a new drug that may slow or stop progression. I looked at some of the companies info about this and it’s dismaying how long ago they started all of this. As we suspect there’s probably not one cure for Parkinson’s. That plus the time on these things makes me think every time I hear “Race for the Cure for Parkinson’s, I think “Facedown, Slow Crawl for the Cure.”
I know companies have to create some thing that works and doesn’t do us in, but good grief. For someone with Parkinson’s it all seems very slow. So of course, we may want to to consider carefully other options, bearing in mind how important safety is.
To me, it’s good to be able to read about 38-year-old male’s thoughts and enthusiasm but also to know and appreciate Art trying to keep us safe.
You’re both doing a heck of a lot more than I am !
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Neupro (Rotigotine transdermal patches) for Parkinson's disease 
Any advice? Good/bad experiences with the Neupro patch for PD? 
Rotigotine/Neupro patches causing deep drowsiness after food
To help or not help, a question of levadopa.
My experiments with supplements
