jnanobiotechnology.biomedce...
Clinical trials of ' gold dust' drug !
jnanobiotechnology.biomedce...
Clinical trials of ' gold dust' drug !
CNM-Au8 is an orally-administered, concentrated suspension of clean-surfaced catalytically-active gold nanocrystals, whose surfaces catalyze the rapid oxidation of NADH to NAD+, increasing the intracellular availability of both NAD+ and ATP in in vitro studies [16, 17]. In multiple preclinical studies, CNM-Au8 has not only been shown to restore energetic homeostasis, but also reduce oxidative stress via superoxide dismutase-like and catalase-like activity.
"via superoxide dismutase-like and catalase-like activity"
This is the process that goes sideways in ALS. I wonder if colloidal gold would be a substitute.
They're always looking for ways to patent an existing unpatentable substance and sell it for a ridiculous amount of money.
SE
So......I'm attempting to answer my own question about colloidal gold being the equivalent to gold nanocrystals. It seems like the term can be used interchangeably.
Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease ncbi.nlm.nih.gov/pmc/articl...
I don't really subscribe to this headline...nanoparticles are also Aluminum and Mercury and other heavy metals that ARE neurotoxic and accumulate in the brain. Synergistic toxicity exists between Al and Hg - it's not 1+1, it's many times more toxic.
I'm starting with hydrogen water first to clear out the heavy metals, ie Aluminum and reduce brain inflammation.
I haven't done the research on how gold interacts with other metals. Here's an interesting observation: Gold (Au) is right next to Mercury (Hg) on the Periodic Table. 🧐 Could Gold displace Mercury in the brain and other tissue? Does colloidal gold cross the blood brain barrier? Could colloidal gold be used as a nasal spray? Maybe the answers are hiding in plain sight.
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"Compared to pre-treatment baseline, the mean NAD+/NADH ratio in the brain, a measure of energetic capacity, was significantly increased by 10.4% after 12 + weeks of treatment with CNM-Au8 (0.584 units, SD: 1.3; p = 0.037, paired t-test) in prespecified analyses of the combined treatment cohorts"
Stat sig but was it clinically significant? Why did they not check UPDRS prior to and then after treatment? Or did they?
I say it often, PD and ALS are related if not different ends of a spectrum. This is more than just overlapping symptoms.
Clinical trials for CNM-Au8 has already happened for ALS.
SE