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How prostate cancer transforms into aggressive NEPC following treatment with anti-androgen therapy.
Because
serine
is a non-essential amino acid, treatments aimed at blocking
serine
production may be devised that could impact the tumor with minimal or no effect on the normal cells, thereby reducing potential toxicities.
Because
serine
is a non-essential amino acid, treatments aimed at blocking
serine
production may be devised that could impact the tumor with minimal or no effect on the normal cells, thereby reducing potential toxicities.
Scout4answers
in
Advanced Prostate Cancer
8 months ago
Selective amino acid restriction therapy (SAART)
For example,
serine
is required for the synthesis of cysteine, and
serine
and glycine are interconvertible through the enzymes
serine
hydroxymethyltransferases SHMT1 and SHMT2 (Figure (Figure1).1).
For example,
serine
is required for the synthesis of cysteine, and
serine
and glycine are interconvertible through the enzymes
serine
hydroxymethyltransferases SHMT1 and SHMT2 (Figure (Figure1).1).
pca2004
in
Fight Prostate Cancer
1 year ago
Does anyone take this supplement?
I have been doing a lot of research on how to fix cramping. Let me first say, no pickle juice does not work. I also do not have fluid taken off during dialysis. I add 400ml of saline each treatment. I also have no fluid restrictions and so I do drink a lot of water. And none of my mineral labs indicate
I have been doing a lot of research on how to fix cramping. Let me first say, no pickle juice does not work. I also do not have fluid taken off during dialysis. I add 400ml of saline each treatment. I also have no fluid restrictions and so I do drink a lot of water. And none of my mineral labs indicate
Bassetmommer
in
Kidney Dialysis
3 days ago
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Could MCAS a possibility?
Hello everyone, I have been wondering for a while if I could have MACS. Last year I was diagnosed with a Raw Pecan allergy, borderline brazil and salami allergy through raw food skin to skin prick testing and given epi pens. My immunologist at the time did not want to risk it as I have asthma and
Hello everyone, I have been wondering for a while if I could have MACS. Last year I was diagnosed with a Raw Pecan allergy, borderline brazil and salami allergy through raw food skin to skin prick testing and given epi pens. My immunologist at the time did not want to risk it as I have asthma and
Owl84
in
The UK Mastocytosis Support Group
7 days ago
Peritoneal dialysis catheter block
Hi everyone, for those on PD, have you had any catheter complications or blockages and how were they resolved? My father suddenly started to have his PD fluid drain bloody two weeks ago. We notified the nurse/dr who are both unresponsive and just assumed it’s a burst blood vessel. We requested a sample
Hi everyone, for those on PD, have you had any catheter complications or blockages and how were they resolved? My father suddenly started to have his PD fluid drain bloody two weeks ago. We notified the nurse/dr who are both unresponsive and just assumed it’s a burst blood vessel. We requested a sample
Marbella17
in
Kidney Disease
10 days ago
do I go ahead with a laparoscopy?
please help me - you’re the only community that who actually helps and understands! I have had 3 miscarriages(natural) - all early. Since my first miscarriage 14 months ago I have been in constant pain. 2/10 half the month and maybe 6-7 for maybe 1 week. I have heavy periods and recently clotting, especially
please help me - you’re the only community that who actually helps and understands! I have had 3 miscarriages(natural) - all early. Since my first miscarriage 14 months ago I have been in constant pain. 2/10 half the month and maybe 6-7 for maybe 1 week. I have heavy periods and recently clotting, especially
Maybeendo
in
Endometriosis UK
13 days ago
WHAT IS THE BEST DIET FOR BRONCHIECTASIS
I HAVE TONS of mucas all the time tho use saline neb and oscillating vest twice a day. adjustable bed but mucas still drains what is the best diet for this illness\?
I HAVE TONS of mucas all the time tho use saline neb and oscillating vest twice a day. adjustable bed but mucas still drains what is the best diet for this illness\?
Lapis5
in
Lung Conditions Community Forum
14 days ago
First Time Nebuliser Use
Hi everyone, my Respiratory Consultant has suggested I try nebulising with saline to help clear my chest and hopefully reduce the problem of mucus plugging which then impacts my breathing obviously. I’ve bought the nebuliser and have the saline on prescription. My query is I’ve read when using for the
Hi everyone, my Respiratory Consultant has suggested I try nebulising with saline to help clear my chest and hopefully reduce the problem of mucus plugging which then impacts my breathing obviously. I’ve bought the nebuliser and have the saline on prescription. My query is I’ve read when using for the
LizPat30
in
Lung Conditions Community Forum
24 days ago
Update on tests etc
hi all. Just an update after my recent CT scan, and the dreaded bronchoscopy on Tuesday this week. Obviously haven't had full results of latest CT scan, apart from a short note from my consultant to say there was a 6.5 millimetre nodule in ththe Apex of my right lung. They will monitor it, if it stays
hi all. Just an update after my recent CT scan, and the dreaded bronchoscopy on Tuesday this week. Obviously haven't had full results of latest CT scan, apart from a short note from my consultant to say there was a 6.5 millimetre nodule in ththe Apex of my right lung. They will monitor it, if it stays
Tiggertheterrier
in
Lung Conditions Community Forum
25 days ago
Salt water washing post adult Circumcision week 6
It has now almost been 6 weeks post my circumcision surgery and the dry patches of skin still linger on my glans and frenulum. I have read on this forum elsewhere that salt water washes help in clearing these dry patches. I was wondering if 1) I should dip it in saline solution before or after taking
It has now almost been 6 weeks post my circumcision surgery and the dry patches of skin still linger on my glans and frenulum. I have read on this forum elsewhere that salt water washes help in clearing these dry patches. I was wondering if 1) I should dip it in saline solution before or after taking
Bisyar
in
Men's Health Forum (Penis Health)
25 days ago
can't get a mucas culture from lungs.
I have had Bronchiectasis for five years and many lung infections.. Pseudomonas etc.and mos of Iv antibiotics. Have never had a problem getting a culure till now.. four times the lab said it was contaminated by oral something or other. So did not run it for respiratory disease. I even went to
I have had Bronchiectasis for five years and many lung infections.. Pseudomonas etc.and mos of Iv antibiotics. Have never had a problem getting a culure till now.. four times the lab said it was contaminated by oral something or other. So did not run it for respiratory disease. I even went to
Lapis5
in
Lung Conditions Community Forum
1 month ago
is my pain Endo + did it cause my miscarriages?
finally a community that I can ask! Please help as I’ve seen so many docs and none can give me an answer. I’ve had 3 miscarriages in 12 months. From ovulation from the 1st pregnancy and ever since I now have lower abdominal pain - maybe 3 out of 4 weeks of the month. I never had this pain before
finally a community that I can ask! Please help as I’ve seen so many docs and none can give me an answer. I’ve had 3 miscarriages in 12 months. From ovulation from the 1st pregnancy and ever since I now have lower abdominal pain - maybe 3 out of 4 weeks of the month. I never had this pain before
Maybeendo
in
Endometriosis UK
1 month ago
Question on steam/vapour breathing
I have a question for those who use steam/vapour breathing to ease off their symptoms. Do you use distilled water, reagular tap water, or a saline solution? My specialist seemed puzzled when I asked her this, and said that, in principle, a saline solution is optimal. I currently use distilled water.
I have a question for those who use steam/vapour breathing to ease off their symptoms. Do you use distilled water, reagular tap water, or a saline solution? My specialist seemed puzzled when I asked her this, and said that, in principle, a saline solution is optimal. I currently use distilled water.
runcyclexcski
in
Asthma Community Forum
2 months ago
Asthma
I'm on a high level of medication for my asthma I've been with lung specialist for 5 years, I was diagnosed with asthma in the 90s but it was mild enough for me to continue work, however as the years increased my asthma was starting to become a problem, well anyway now my asthma has become a real problem
I'm on a high level of medication for my asthma I've been with lung specialist for 5 years, I was diagnosed with asthma in the 90s but it was mild enough for me to continue work, however as the years increased my asthma was starting to become a problem, well anyway now my asthma has become a real problem
Happy103
in
Lung Conditions Community Forum
2 months ago
Rheumatologist advices no reduction of prednisolone while adrenal glands not working and has issued emergency hydrocortisone kit
I've had PMR since October 2020 and managed to get down to 2.5mg of prednisolone in February 2023. But after a flare, I had to raise it to 5mg and have been pain-free since then. I started on methotrexate weekly injections (15mg) in December 2023, with the hope of being able to reduce the prednisolone
I've had PMR since October 2020 and managed to get down to 2.5mg of prednisolone in February 2023. But after a flare, I had to raise it to 5mg and have been pain-free since then. I started on methotrexate weekly injections (15mg) in December 2023, with the hope of being able to reduce the prednisolone
harpsichor
in
PMRGCAuk
2 months ago
Better Understanding
I knew and expressed here that I was fearful of crashing this winter as I have since 1995 to varying degrees. I had set a marker of April 01 as a measure. I was successful although I will wait until April 01 to see it in my rear view mirror, and have a celebration although I am already celebrating. Some
I knew and expressed here that I was fearful of crashing this winter as I have since 1995 to varying degrees. I had set a marker of April 01 as a measure. I was successful although I will wait until April 01 to see it in my rear view mirror, and have a celebration although I am already celebrating. Some
WIZARD6787
in
Pernicious Anaemia Society
3 months ago
antihistamines
hi 👋🏻 think I need some antihistamines to help my ETD. I’ve been using Sudafed last 2 days because the steroid nasal sprays seem to make my ears sore. I know you can only use them for a few days though. I can literally feel the swelling reducing and then swelling up again. So maybe I need an antihistamine
hi 👋🏻 think I need some antihistamines to help my ETD. I’ve been using Sudafed last 2 days because the steroid nasal sprays seem to make my ears sore. I know you can only use them for a few days though. I can literally feel the swelling reducing and then swelling up again. So maybe I need an antihistamine
Lakeshiker
in
Tinnitus UK
3 months ago
steroid nasal sprays
hi everyone, I’ve been using a steroid nasal spray for ETD and I think it’s making my ears sore and my T louder 🤔 Just wondering if anyone has had similar experiences. My ears get sore and all down the side of my face near my jaw line from my ear to my neck. My right ear registered negative pressure
hi everyone, I’ve been using a steroid nasal spray for ETD and I think it’s making my ears sore and my T louder 🤔 Just wondering if anyone has had similar experiences. My ears get sore and all down the side of my face near my jaw line from my ear to my neck. My right ear registered negative pressure
Lakeshiker
in
Tinnitus UK
4 months ago
0.9 saline 1 liter IV infusion.
Last year I asked on the forum if anyone knew where I could get a saline infusion. Come to find out that was heretical and not done in the UK. 🙂 In the USA there are clinics owned and run by nurses where one can get infusions with or without vitamins of your choice. There are also mobile clinics.
Last year I asked on the forum if anyone knew where I could get a saline infusion. Come to find out that was heretical and not done in the UK. 🙂 In the USA there are clinics owned and run by nurses where one can get infusions with or without vitamins of your choice. There are also mobile clinics.
WIZARD6787
in
Pernicious Anaemia Society
4 months ago
Body Temperature Regulation.
How body temperature regulation made it in the symptoms list of the neurological effects of B12 deficiency I have not yet come across. I have experienced body temperature regulation issues my whole life. It results in mild hypothermia. I am well versed in the physicians and nurses understanding of
How body temperature regulation made it in the symptoms list of the neurological effects of B12 deficiency I have not yet come across. I have experienced body temperature regulation issues my whole life. It results in mild hypothermia. I am well versed in the physicians and nurses understanding of
WIZARD6787
in
Pernicious Anaemia Society
4 months ago
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