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Opicapone
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When does Opicapone work?
For those who are taking
Opicapone
, how many days it needs for it to start to work? I started 2 nights ago at 11pm after 400 mg di Sinemet during the day, but it is like to eat a candy: nothing happens đź«Ą
For those who are taking
Opicapone
, how many days it needs for it to start to work? I started 2 nights ago at 11pm after 400 mg di Sinemet during the day, but it is like to eat a candy: nothing happens đź«Ą
michelagvolpe
in
Cure Parkinson's
10 months ago
Opicapone helps prolong plasma levodopa levels in patients with Parkinson’s
- Once-daily
opicapone
50 mg with carbidopa/levodopa helped achieve and maintain plasma concentrations of levodopa in patients with PD.- Maximum COMT inhibition was nearly 85% at day 14. - Adding once-daily
opicapone
50 mg to carbidopa/levodopa therapy helped achieve and maintain plasma concentrations
- Once-daily
opicapone
50 mg with carbidopa/levodopa helped achieve and maintain plasma concentrations of levodopa in patients with PD.- Maximum COMT inhibition was nearly 85% at day 14. - Adding once-daily
opicapone
50 mg to carbidopa/levodopa therapy helped achieve and maintain plasma concentrations
Farooqji
in
Cure Parkinson's
1 year ago
Time to try some extended release?
I ran into
opicapone
, a.k.a. Ongentys, and it seemed to sound like a better option than Entacapone, so I ordered a three month supply of it. I’m now two months on Ongentys, and it’s no more effective than Entacapone.
I ran into
opicapone
, a.k.a. Ongentys, and it seemed to sound like a better option than Entacapone, so I ordered a three month supply of it. I’m now two months on Ongentys, and it’s no more effective than Entacapone.
Dpeachey
in
Cure Parkinson's
9 months ago
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rasagiline (Azilect) vs Xadago (safinamide) be. Ongentys (opicapone)
Hello all, I have been experiencing off times about 3 1/2 hours after taking one C/L, so my MDS suggested one of these three medications as an add on. (I started with Nourianz, which had no effect. I’m wondering about what people’s experiences has been with any of these drugs? Pros and cons? Thanks
Hello all, I have been experiencing off times about 3 1/2 hours after taking one C/L, so my MDS suggested one of these three medications as an add on. (I started with Nourianz, which had no effect. I’m wondering about what people’s experiences has been with any of these drugs? Pros and cons? Thanks
jocelyng
in
Cure Parkinson's
5 days ago
opicapone
These days my doctors have prescribed me
opicapone
in combination with levodopa. I currently take 600mg of Sinemet, 10mg of selegiline and 3 grams of Vitamin B1 per day. I wanted to ask who takes
opicapone
their experience in this regard.
These days my doctors have prescribed me
opicapone
in combination with levodopa. I currently take 600mg of Sinemet, 10mg of selegiline and 3 grams of Vitamin B1 per day. I wanted to ask who takes
opicapone
their experience in this regard.
Axter
in
Cure Parkinson's
2 years ago
Safinamide. Opicapone
does anyone have any news views or opinions on these drugs ?
does anyone have any news views or opinions on these drugs ?
M-o-ggy
in
Cure Parkinson's
2 years ago
Supplements to help thiamin (B1) therapy
I recently saw my neurologist & he wants to put me on
Opicapone
, as my off times are getting longer, however I would rather like to give the B1 therapy another go before trying this new medication. This time with magnesium & B complex.
I recently saw my neurologist & he wants to put me on
Opicapone
, as my off times are getting longer, however I would rather like to give the B1 therapy another go before trying this new medication. This time with magnesium & B complex.
LinnyGee
in
Cure Parkinson's
2 years ago
video: Design of the EPSILON trial of opicapone as an add-on to levodopa in early PD
https://www.youtube.com/watch?v=LA6CdWs6Y1w
https://www.youtube.com/watch?v=LA6CdWs6Y1w
Hidden
in
Cure Parkinson's
2 years ago
The rationale & design of the Phase IV randomised, double-blind, double-blind OCEAN (OpiCapone Effect on motor fluctuations & pAiN) trial
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02602-8 more on
OpiCapone
https://www.youtube.com/watch?v=S7gqfynW-wI
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02602-8 more on
OpiCapone
https://www.youtube.com/watch?v=S7gqfynW-wI
Hidden
in
Cure Parkinson's
2 years ago
Opicapone: A third generation COMT inhibitor
Opicapone
is used once daily as adjunctive to levodopa/carbidopa to reduce “off” periods in patients with Parkinson’s disease.
Opicapone
is used once daily as adjunctive to levodopa/carbidopa to reduce “off” periods in patients with Parkinson’s disease.
Farooqji
in
Cure Parkinson's
3 years ago
Opicapone not lasting 24 hours
Can
Opicapone
be taken in the morning instead of the evening? This would be more useful as it's effectiveness does not last for 24 hours.
Can
Opicapone
be taken in the morning instead of the evening? This would be more useful as it's effectiveness does not last for 24 hours.
mandolinmann
in
Cure Parkinson's
4 years ago
Who uses Opicapone?
I'm being prescribed a COMT inhibitor
Opicapone
to try and extend my 'on time'. I was wondering if anyone uses this already and has it worked for them? 🤔
I'm being prescribed a COMT inhibitor
Opicapone
to try and extend my 'on time'. I was wondering if anyone uses this already and has it worked for them? 🤔
gingerj
in
Cure Parkinson's
4 years ago
How much simemet are you taking once you have been diagonsed 5-6years and the honeymoon period is over
I have tried amantadine ,
opicapone
and entacapone but they have all made my symptoms worse. The future looks bleak unless can find a way to extend the on time. Do people find that food has a major part to play in there ons.
I have tried amantadine ,
opicapone
and entacapone but they have all made my symptoms worse. The future looks bleak unless can find a way to extend the on time. Do people find that food has a major part to play in there ons.
Connie18
in
Cure Parkinson's
5 years ago
Opicapone
My husband was given
Opicapone
about 18 months ago but stopped taking it for some reason. He started taking it again just over a month ago. He found immediate improvement with it eg. not having to go to the toilet so often during the night but he is finding it difficult to get the correct dose.
My husband was given
Opicapone
about 18 months ago but stopped taking it for some reason. He started taking it again just over a month ago. He found immediate improvement with it eg. not having to go to the toilet so often during the night but he is finding it difficult to get the correct dose.
JeanieBeanie
in
Cure Parkinson's
5 years ago
Fluctuating blood pressure - role of P.D. drugs which impact catecholamine production and levels
I am trying to find out if there has been any research into role of the PD drugs which have a direct effect on catecholamines - COMT inhibitors, eg entacapone..
opicapone
, MAOI (B)s eg safinamide rasagaline, and SNRIs eg mirtazapine.
I am trying to find out if there has been any research into role of the PD drugs which have a direct effect on catecholamines - COMT inhibitors, eg entacapone..
opicapone
, MAOI (B)s eg safinamide rasagaline, and SNRIs eg mirtazapine.
pen1
in
Cure Parkinson's
5 years ago
High Dose Sinemet
A few months ago she was given
Opicapone
. I thought it was the answer to my prayers until she started hearing music and finally after 5 weeks hallucinating badly. I titrated her Sinemet down and down and down ...still she hallucinated finally I took her off
Opicapone
.
A few months ago she was given
Opicapone
. I thought it was the answer to my prayers until she started hearing music and finally after 5 weeks hallucinating badly. I titrated her Sinemet down and down and down ...still she hallucinated finally I took her off
Opicapone
.
heidle
in
Cure Parkinson's
5 years ago
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That Opicapone Added To Levodopa Resulted In A Significant improvement
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That
Opicapone
Added To Levodopa Resulted In A Significant And Sustained Increase In ON Time Without Troublesome Dyskinesia In Parkinson's Disease Patients With Motor Fluctuations https://www.gurufocus.com/news/870917/neurocrine-biosciences-presents-phase-iii-data-analysis-demonstrating-that-
opicapone
-added-to-levodopa-resulted-in-a-significant-and-sustained-increase-in-on-time-without-troublesome-dyskinesia-in-parkinsons-disease-patients-with-motor-fluctuations
Neurocrine Biosciences Presents Phase III Data Analysis Demonstrating That
Opicapone
Added To Levodopa Resulted In A Significant And Sustained Increase In ON Time Without Troublesome Dyskinesia In Parkinson's Disease Patients With Motor Fluctuations https://www.gurufocus.com/news/870917/neurocrine-biosciences-presents-phase-iii-data-analysis-demonstrating-that-
opicapone
-added-to-levodopa-resulted-in-a-significant-and-sustained-increase-in-on-time-without-troublesome-dyskinesia-in-parkinsons-disease-patients-with-motor-fluctuations
Farooqji
in
Cure Parkinson's
5 years ago
Opicapone once-daily, against off periods..!!
Once-daily treatment with
opicapone
provides continued reductions of off periods in Parkinson’s patients taking levodopa, Neurocrine Biosciences’ Phase 3 clinical study shows. https://parkinsonsnewstoday.com/2018/08/22/
opicapone
-superior-comtan-according-parkinsons-phase-3-study/?
Once-daily treatment with
opicapone
provides continued reductions of off periods in Parkinson’s patients taking levodopa, Neurocrine Biosciences’ Phase 3 clinical study shows. https://parkinsonsnewstoday.com/2018/08/22/
opicapone
-superior-comtan-according-parkinsons-phase-3-study/?
dadcor
in
Cure Parkinson's
6 years ago
Opicapone Superior to Comtan in Providing Motor Benefits to Parkinson’s Patients, Phase 3 Study Shows
https://parkinsonsnewstoday.com/2018/08/22/
opicapone
-superior-comtan-according-parkinsons-phase-3-study/
https://parkinsonsnewstoday.com/2018/08/22/
opicapone
-superior-comtan-according-parkinsons-phase-3-study/
Farooqji
in
Cure Parkinson's
6 years ago
Madopar instead of Sinemet
My friend currently takes one Madopar in the morning and 4 x Sinemet during the day but is'nt getting much relieve from the Sinemet like she used to ( diagnosed for 5 years) She also takes 1 x
Opicapone
in the evening She seems to be getting a better response from the Madopar so the question is Can
My friend currently takes one Madopar in the morning and 4 x Sinemet during the day but is'nt getting much relieve from the Sinemet like she used to ( diagnosed for 5 years) She also takes 1 x
Opicapone
in the evening She seems to be getting a better response from the Madopar so the question is Can
Seashore60
in
Cure Parkinson's
6 years ago
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