Can I get some advice on my latest results, please?

[BookLover2020]

Hello All

I recently had my blood test through my GP for my Vitamin D and other tests.

(Currently on 100mcg T4 and 10mcg T3 due to see my endo around July 2024)

Date: 02/05/2024 (Early morning fasting after taking my Levo and T3).

Serum Vitamin B12 239 ng/L [200 - 900]

Serum Vitamin D 101 nmol/L [50 - 200]

Serum ferritin Level 155ug/L [30 - 300]

Serum folate level 4.6ug/L [3 - 20.5]

Serum creatinine level 112 umol/L [64.0 - 104.0]; Above high reference limit

eGFR using creatinine (CKD-EPI) per 1.73 square metres 68 mL/min [90.0 - 120.0];

Previous test result for Thyroid function test:

healthunlocked.com/thyroidu...

Supplements that I take currently:

1. Cytoplan Vitamin D3 and K2

2. Cytoplan Selenium

3. Cytoplan Magnesium Threonate ( Planning to discontinue after the current stock finishes)

4. Cytoplan Fish Oil Capsules

5. Cytoplan Blood Glucose Support ( Started in April 204 )

Based on the results above, would it help if I should be looking for any other supplement?

Thank you

[TiggerMe]

A good B complex as your B12 and folate are low.... healthunlocked.com/thyroidu...

Don't rate the Cytoplan ones either too much B6 or the wrong type

[greygoose]

Cytoplan Blood Glucose Support is not a good thing for a hypo to take because it contains zinc and copper. Hypos are usually high in one (very often copper) and therefore low in the other. And taking more of the one you're high in will lower the other one even further. So, they both should be tested before supplementing them in any way.

Are you planning to stop your magnesium supplement because of the magnesium in this multi-mineral? If so, that's not a good idea because there's not enough of it. And, if you're taking vit D you need a constant supply of enough magnesium - usually about 350 mg - to support the vit D, and do everything else it does. And you're probably deficient in magnesium, anyway, most people are.

Serum Vitamin B12 239 ng/L [200 - 900]

Dangerously low. Are you vegetarian? If not, your doctor should be testing you for Pernicious Anemia. Your folate is also low, should be in double figures.

[BookLover2020 in reply to greygoose]

I am not vegetarian. I will look at ordering a supplement to increase my Vitamin B12.

[Stourie in reply to BookLover2020]

Hi you would be better to get checked for pernicious anaemia before you start to supplement b12 and the complex as that will just skew your results. Jo xx

[BookLover2020 in reply to Stourie]

@Stourie: I have also done the Full Blood Count in April 2024

Will that help to detect pernicious anaemia?

[Stourie in reply to BookLover2020]

Hi, not sure. I think you would have to ask for the test specifically. Jo xx

[SlowDragon Administrator]

previous post with detailed advice on what to take to improve extremely low B12 and folate

healthunlocked.com/thyroidu...

You MUST test TSH, Ft4 and Ft3 together BEFORE appointment with endo

Retest thyroid and vitamin levels 6-8 weeks after adding daily B12 and daily vitamin B complex

You likely need dose increase in Levo

100mcg is probably not enough with Ft4 only 50% through range

Would GP increase levothyroxine by 12.5mcg daily? (Cut 25mcg in half)

[BookLover2020 in reply to SlowDragon]

Thank you @SlowDragon.

I usually do test for TSH and others before the appointment with Endo.

Would GP increase levothyroxine by 12.5mcg daily?

I prefer to see my endo and then decide re Levo increase.

Meanwhile I will look at adding daily B12 and daily Vitamin B complex

[BookLover2020 in reply to BookLover2020]

Based on the advice, I have ordered Igennus B complex

( igennus.com/collections/all... )

Let's see if I will feel better.

I am not sure if it's relevant, I have both these markers:

rs1801133

rs1801131

And I understand because of this markers in MTHFR gene, conversion of folic acid to folate is affected.

Thank you.

[SlowDragon Administrator in reply to BookLover2020]

You definitely need a separate B12 as well as vitamin B complex

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement

A week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

[BookLover2020 in reply to SlowDragon]

   SlowDragon

Below are the values that I see in 23andme:

Gene: MTHFR

Marker: rs1801133

Build 37 11856378 A or G G / G

Build 38 11796321 A or G G / G

Gene: MTHFR

Marker: rs1801131

Build 37 11854476 G or T G / T

Build 38 11794419 G or T G / T

Can someone please help me understand the above result?

Thank you.

[SlowDragon Administrator in reply to BookLover2020]

You might be able to upload your DNA results here for analysis

mthfr-genetics.co.uk

I used this for analysis of Ancestry DNA

[BookLover2020 in reply to SlowDragon]

Thank you SlowDragon .

I have ordered Functional Genomics Report from them.

[redhead41]

Did you leave 24 hours betw levo and 12 hours betw T3 and the Bld draw?

[BookLover2020 in reply to redhead41]

I didn't last time but I will aim to this time.

[redhead41 in reply to BookLover2020]

Well before you start altering dosages, I think you need accurate testing.

[BookLover2020 in reply to redhead41]

Agreed.

[SlowDragon Administrator in reply to BookLover2020]

How long before test was last dose Levo

ALWAYS test with last dose Levo 24 hours before test

And day before test split T3 as 3 smaller doses

5mcg waking, 2.5mcg mid afternoon and 2.5mcg 8-12 hours before test

[SmallBlueThing]

Has the Blood Glucose Support had any effect on your HbA1c, or is it meant for something else?

[BookLover2020 in reply to SmallBlueThing]

It is supposed to help with sugar spike/crashes.

I don't know if it helped but I stopped taking sugar(sugar in my tea and coffee; no cakes no biscuits or sugary foods) around April 2024.

It's too early to tell but let's see if it helps.

[SmallBlueThing in reply to BookLover2020]

Thanks. To keep my HbA1c in range, I also have to much reduce the amount of potatoes and grains I consume. Eating a lot more leafy greens means my folate level is fine.

[Tina_Maria in reply to BookLover2020]

The thing is, if your thyroid hormones are not optimised, your blood sugar can go up, as can your cholesterol. Once your thyroid is working properly, the ranges will come down. This is why it is essential to have the right levels of hormones, as this can sort out many other things that go with having to little thyroid hormones (glucose, cholesterol, brain fog...).

Many many moons ago, thyroid deficiency was picked up when people presented with elevated cholesterol or glucose levels.... before the over-reliance on the TSH testing...😢

[BookLover2020 in reply to Tina_Maria]

Thank you Tina.

My main symptom is brain fog. If I do have a good night's sleep, it's better the next day.

I wonder if there is any issue with blood circulation in the brain.

Hence my question about Gingko Biloba. I have used it in the past.

healthunlocked.com/thyroidu...

[Tina_Maria in reply to BookLover2020]

I have used Ginko Biloba also in the past (many moons ago to prepare for an exam) and it has helped with clarity.

The problem is though, if your thyroid hormones are not optimised, taking Ginko Biloba will only have a limited effect, as it is not the underlying problem. The problem is the inadequate treatment of your thyroid. Once that is optimised (e.g., an increase) and properly treated, your brain fog will improve or even resolve. I had really bad brain fog when my GP insisted on reducing my thyroid hormones due to the suppressed TSH. The reduction did not change the TSH at all, but my free T3 and T4 fell and I was anxious, depressed, low on energy and had awful brain fog. After I ignored the GP and went back on my previous dose, all symptoms improved and the brain fog went as well.