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[i]Just received an announcement from our friends at MPN Advocacy & Education International of some interesting upcoming events. [/i] [u]
Webinars
[/u] A Conversation with an MPN Specialist: Everything You Should Know About Clinical Trials Tuesday, February 28, 2023 1:30 - 3:00 pm EST
[i]Just received an announcement from our friends at MPN Advocacy & Education International of some interesting upcoming events. [/i] [u]
Webinars
[/u] A Conversation with an MPN Specialist: Everything You Should Know About Clinical Trials Tuesday, February 28, 2023 1:30 - 3:00 pm EST
hunter5582
in
MPN Voice
1 year ago
depression maybe
Stress and anxiety has been kicking my butt lately. And today I had barely any energy and I can’t think of anything fun that I actually want to do. My plan is to rest tonight and then tomorrow do things that I’d love if I felt up to it and just do it anyway so I don’t sink into a deeper depression.
Stress and anxiety has been kicking my butt lately. And today I had barely any energy and I can’t think of anything fun that I actually want to do. My plan is to rest tonight and then tomorrow do things that I’d love if I felt up to it and just do it anyway so I don’t sink into a deeper depression.
Starrlight
in
Anxiety and Depression Support
2 years ago
IRL1117, Potential Improvement on Levodopa, May Enter Clinical Trial
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
Farooqji
in
Cure Parkinson's
1 year ago
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I don't know what this Melatonin blurb is trying to say
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
Bolt_Upright
in
Cure Parkinson's
1 year ago
Dark circles around eyes
I know it’s a vanity thing but does anyone else suffer from eyes that almost look like you’ve got a black eye? Since being on prednisone I have huge dark hollows under both eyes - not sure if it’s the drugs or insomnia - probably both. I’m 54 and I see photos before the pmr hit a year ago compared
I know it’s a vanity thing but does anyone else suffer from eyes that almost look like you’ve got a black eye? Since being on prednisone I have huge dark hollows under both eyes - not sure if it’s the drugs or insomnia - probably both. I’m 54 and I see photos before the pmr hit a year ago compared
Aeowin777
in
PMRGCAuk
2 years ago
Choose Capivasertib or 177Lu-PSMA-617 clinical trial or stick with ADT + radiation?
Hi Folks, My PSA is up to 49 from 24 last summer. After bone scan, CT scan indicated 3 sites of mets (2 on pelvis, 1 on L5, overall “low volume”). Otherwise feeling great, working out most days. 58. I was finally able to get in this month to see a Medical Oncologist. Starting on ADT next week. Meeting
Hi Folks, My PSA is up to 49 from 24 last summer. After bone scan, CT scan indicated 3 sites of mets (2 on pelvis, 1 on L5, overall “low volume”). Otherwise feeling great, working out most days. 58. I was finally able to get in this month to see a Medical Oncologist. Starting on ADT next week. Meeting
LongTimeRunning
in
Advanced Prostate Cancer
1 year ago
Depressed, hopeless and sleep deprived with RLS. HELP??
I’ve had RLS for 40 years and have been on almost every medicine out there. I’ve been in Requip for 6 years - 2 mg XL, 2 2mg Requip along with clonopin & methadone. My neurologist of 15 years has given up on me. I saw another one a few weeks ago and she said everything she’d prescribe, I’ve already
I’ve had RLS for 40 years and have been on almost every medicine out there. I’ve been in Requip for 6 years - 2 mg XL, 2 2mg Requip along with clonopin & methadone. My neurologist of 15 years has given up on me. I saw another one a few weeks ago and she said everything she’d prescribe, I’ve already
SleeplessinDenver
in
Restless Legs Syndrome
2 years ago
Terbium-161 instead of Lutetium-177
Here's an intriguing abstract from the ASCO conference that is going on right now (February 2023). Hofman and company in Australia are starting a clinical trial (NCT05521412) to evaluate using Tb-161 instead of Lu-177 linked to the PSMA-I&T targeting ligand. The hope is that the shorter range and higher
Here's an intriguing abstract from the ASCO conference that is going on right now (February 2023). Hofman and company in Australia are starting a clinical trial (NCT05521412) to evaluate using Tb-161 instead of Lu-177 linked to the PSMA-I&T targeting ligand. The hope is that the shorter range and higher
TeleGuy
in
Advanced Prostate Cancer
1 year ago
177LU-DTPA-SC16 attaching DLL3 for neuroendocrine cancer
25% of pCA develop into neuroendocrine variant. Research show good preclinical results. Has anyone information of a clinical trial at MSKCC using SC16 as a monoclonal antibody? https://pubmed.ncbi.nlm.nih.gov/35759660/
25% of pCA develop into neuroendocrine variant. Research show good preclinical results. Has anyone information of a clinical trial at MSKCC using SC16 as a monoclonal antibody? https://pubmed.ncbi.nlm.nih.gov/35759660/
Hidden
in
Advanced Prostate Cancer
1 year ago
📚 Research 101: Who can take part in a clinical trial?
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
AnnaHU
HealthUnlocked
in
Research Opportunities
1 year ago
Focal Ablation doesn't work (again)
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Tall_Allen
in
Prostate Cancer Network
1 year ago
Ambroxol
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Badmouth
in
Cure Parkinson's
1 year ago
New here.. in search of support.
Simply looking for any sources for support for my conditions of anxiety m, depression, & agoraphobia.
Simply looking for any sources for support for my conditions of anxiety m, depression, & agoraphobia.
Walking-Inthesun
in
Anxiety and Depression Support
2 years ago
The immune system doesn't know that your eye's exist - Ocular immune privilege
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948372/#:~:text=The%20eye%20has%20a%20special,were%20not%20rejected%20%5B1%5D. The eye has a special relationship with the immune system, known as immune privilege. The term was coined in the 1940s by Sir Peter Medawar, who noticed that foreign tissue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948372/#:~:text=The%20eye%20has%20a%20special,were%20not%20rejected%20%5B1%5D. The eye has a special relationship with the immune system, known as immune privilege. The term was coined in the 1940s by Sir Peter Medawar, who noticed that foreign tissue
zaax
in
CLL Support
2 years ago
Any advice about future treatment?
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Riverflo
in
My Ovacome
1 year ago
To those who replied to my question on clinical trials
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
MyMiracle13
in
SHARE Metastatic Breast Cancer
1 year ago
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Bolt_Upright
in
Cure Parkinson's
1 year ago
IVIG after heart surgery and stopping IBRUTIMIB
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
misterbee
in
CLL Support
1 year ago
Self Hate
Anyone else have a lot of self-hatred? What are you doing to cope or conquer these feelings? I feel like the "hole" I am in is getting deeper and deeper - and worried that I might actually get the courage to do something stupid.
Anyone else have a lot of self-hatred? What are you doing to cope or conquer these feelings? I feel like the "hole" I am in is getting deeper and deeper - and worried that I might actually get the courage to do something stupid.
Tough-Fry
in
Anxiety and Depression Support
2 years ago
MPR flare-up or Aclasta reaction?
Went off prednisone early in July 2022. Was fine till 10 days ago. Started with pain in my legs and with 5 days spread through my whole body - same as I had when I was diagnosed with PMR in March 2020. Because of a low bone density scan the specialist physician recommended Aclasta infusion that was done
Went off prednisone early in July 2022. Was fine till 10 days ago. Started with pain in my legs and with 5 days spread through my whole body - same as I had when I was diagnosed with PMR in March 2020. Because of a low bone density scan the specialist physician recommended Aclasta infusion that was done
DeWet
in
PMRGCAuk
2 years ago
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