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Clinical depression
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first time here-First post
Hi everyone. I have been on my health journey for many years through counseling for things like anger and depression. I have been fairly successful in my life and have overcome much. I raised a family and was able to cope with anxiety. But after my divorce, anxiety took root and intensified. It’s been
Hi everyone. I have been on my health journey for many years through counseling for things like anger and depression. I have been fairly successful in my life and have overcome much. I raised a family and was able to cope with anxiety. But after my divorce, anxiety took root and intensified. It’s been
JustRide
in
Anxiety and Depression Support
1 year ago
Wait or start docetaxel?
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
Currently taking Nubeqa and Orgovyx but PSA doubling time is only 7 weeks and PSMA scan shows activity in abdominal lymph nodes, 2 vertebrae and 2 ribs. MO suggested DORA Clinical trial (everyone gets docetaxel, half get radium) but the head of a trial I was previously in at NIH feels that unless a CT
AllenMarco
in
Advanced Prostate Cancer
6 months ago
Clinical trial: keep an eye on this
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
First results should be available by the first months of 2024. Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive
Maxone73
in
Advanced Prostate Cancer
6 months ago
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Bowel irrigation (Not "colonic irrigation")
I have obstructed defecation (anismus) which has not responded to biofeedback etc. The next step is at home bowel irrigation and I am just waiting for an appointment with the bowel nurse to issue me with the equipment. It would be helpful to hear of anyone`s experience with this. I don`t know which
I have obstructed defecation (anismus) which has not responded to biofeedback etc. The next step is at home bowel irrigation and I am just waiting for an appointment with the bowel nurse to issue me with the equipment. It would be helpful to hear of anyone`s experience with this. I don`t know which
janke
in
IBS Network
1 year ago
Researchers add to existing evidence that vitamin B3 may help slow down the progression of Parkinson'
https://www.parkinsons.org.uk/news/more-research-shows-potential-benefits-vitamin-b3-parkinsons A new phase 1 clinical trial, the NR-SAFE study, has published promising signs that taking a high dose of vitamin B3 is safe, and can reduce some symptoms for people with Parkinson’s.
https://www.parkinsons.org.uk/news/more-research-shows-potential-benefits-vitamin-b3-parkinsons A new phase 1 clinical trial, the NR-SAFE study, has published promising signs that taking a high dose of vitamin B3 is safe, and can reduce some symptoms for people with Parkinson’s.
CuriousMe12
in
Cure Parkinson's
6 months ago
Cancer causation -- inflammation and statistics
https://www.newyorker.com/magazine/2023/12/18/all-the-carcinogens-we-cannot-see Those of us whose cancer is quiet don't want to wake it up, but nobody knows for sure what to do (or not do). This article provides some food for thought and offers the opportunity for us to revisit our views about the
https://www.newyorker.com/magazine/2023/12/18/all-the-carcinogens-we-cannot-see Those of us whose cancer is quiet don't want to wake it up, but nobody knows for sure what to do (or not do). This article provides some food for thought and offers the opportunity for us to revisit our views about the
mistersafety
in
Advanced Prostate Cancer
6 months ago
depression
I don’t know how long it lasted but it was replaced with
clinical
depression
. when first receiving counselling, all I could do was sob continually and blurt out that I didn’t know who I was anymore.
I don’t know how long it lasted but it was replaced with
clinical
depression
. when first receiving counselling, all I could do was sob continually and blurt out that I didn’t know who I was anymore.
Steveau
in
Headway
5 months ago
Does Buspirone take time to work
I moved the actual question to the front. Lol. Too much rant. My question is: If any of you take buspirone, what were You told, please, as far as how it works? This is kind of a "poll" for my arsenal, not something I intend to use as medical advice. ***Were you told it takes awhile to work, and
I moved the actual question to the front. Lol. Too much rant. My question is: If any of you take buspirone, what were You told, please, as far as how it works? This is kind of a "poll" for my arsenal, not something I intend to use as medical advice. ***Were you told it takes awhile to work, and
Hidden
in
Anxiety and Depression Support
1 year ago
Restless Leg Syndrome, neuromodulation..
Treatment was well tolerated, and no adverse events were reported. Our case series shows a potential role for self-administered taVNS in patients with severe pharmacoresistant RLS. Hartley S, Bao G, Russo A, Zagdoun M, Chevallier S, Lofaso F, Leotard A, Azabou E. Self-administered non-invasive vagus
Treatment was well tolerated, and no adverse events were reported. Our case series shows a potential role for self-administered taVNS in patients with severe pharmacoresistant RLS. Hartley S, Bao G, Russo A, Zagdoun M, Chevallier S, Lofaso F, Leotard A, Azabou E. Self-administered non-invasive vagus
House2
in
Restless Legs Syndrome
6 months ago
Old new approach! MYC inhibitors
myc is a gene present in most kinds of cancer, something has reached clinical trials at last! https://www.peptomyc.com/results-revealed-from-phase-i-clinical-trial-of-the-first-drug-to-successfully-inhibit-the-myc-gene-which-drives-many-common-cancers/
myc is a gene present in most kinds of cancer, something has reached clinical trials at last! https://www.peptomyc.com/results-revealed-from-phase-i-clinical-trial-of-the-first-drug-to-successfully-inhibit-the-myc-gene-which-drives-many-common-cancers/
Maxone73
in
Advanced Prostate Cancer
6 months ago
Advances in solid tumors: finnish clinical trial
Interesting results are coming! Bexmarilimab seems to be able to improve immunotherapy. It was not yet tested on prostate cancer, but it's already commercially used to treat blood malignacies. As single agent: https://www.faron.com/our-science/clinical-trials/matins "Latest data showed a three-fold
Interesting results are coming! Bexmarilimab seems to be able to improve immunotherapy. It was not yet tested on prostate cancer, but it's already commercially used to treat blood malignacies. As single agent: https://www.faron.com/our-science/clinical-trials/matins "Latest data showed a three-fold
Maxone73
in
Advanced Prostate Cancer
6 months ago
Need to Change Treatment
So I have progression after two years on Ibrance and Letrozole. I have an opportunity to participate in a clinical trial in my town in which I would be randomly assigned to Giredestrant, a promising oral SERD (monotherapy) or both Giredestrant with a new Pikc3a drug. My standard of care option would
So I have progression after two years on Ibrance and Letrozole. I have an opportunity to participate in a clinical trial in my town in which I would be randomly assigned to Giredestrant, a promising oral SERD (monotherapy) or both Giredestrant with a new Pikc3a drug. My standard of care option would
Trissh
in
SHARE Metastatic Breast Cancer
6 months ago
Intense jaw pain (pt.2)
Three months ago my husband developed intense right jaw pain. After multiple scans showing "something" (thankfully no PSMA activity) he had a surgical bone biopsy 11/29. Two days ago we received the pathology report but have not been able to speak with the Dr. to help us understand it. The good news
Three months ago my husband developed intense right jaw pain. After multiple scans showing "something" (thankfully no PSMA activity) he had a surgical bone biopsy 11/29. Two days ago we received the pathology report but have not been able to speak with the Dr. to help us understand it. The good news
Decktime
in
Advanced Prostate Cancer
6 months ago
ST-067 in combination with pembrolizumab clinical trial
https://www.moffitt.org/clinical-trials-and-studies/clinical-trial-21340/
https://www.moffitt.org/clinical-trials-and-studies/clinical-trial-21340/
Maxone73
in
Advanced Prostate Cancer
6 months ago
Anyone can access this article?
"As Bertagnolli steps in, NIH and FDA reenvision clinical trials and evidence generation"..it could be the modernization of clinical trials I have been waiting for The only Monica Bertagnolli I knew was a tough girl, I want to see if this Monica is also such a tough cookie https://cancerletter.com
"As Bertagnolli steps in, NIH and FDA reenvision clinical trials and evidence generation"..it could be the modernization of clinical trials I have been waiting for The only Monica Bertagnolli I knew was a tough girl, I want to see if this Monica is also such a tough cookie https://cancerletter.com
Maxone73
in
Advanced Prostate Cancer
6 months ago
My Current Stack (What is in Yours?)
Fabnusasked me what my current stack was so I am sharing it here. Please remember I have not been diagnosed with PD. I have RBD and some other symptoms.
Also remember I have a HS degree, poor impulse control, and I am prone to bad decisions. Please do your own research.
The best place
Fabnusasked me what my current stack was so I am sharing it here. Please remember I have not been diagnosed with PD. I have RBD and some other symptoms.
Also remember I have a HS degree, poor impulse control, and I am prone to bad decisions. Please do your own research.
The best place
Bolt_Upright
in
Cure Parkinson's
1 year ago
Prednislone and Anxiety
I've been reducing from 20mg pred since November 2022, currently on 11mg. Since Christmas I have had episodes of extreme anxiety, depression, mood swings and tearfulness. My Rheumy this morning suggested swapping to Betamethasone which does not cross the blood/brain barrier. However, when I researched
I've been reducing from 20mg pred since November 2022, currently on 11mg. Since Christmas I have had episodes of extreme anxiety, depression, mood swings and tearfulness. My Rheumy this morning suggested swapping to Betamethasone which does not cross the blood/brain barrier. However, when I researched
FleetRose
in
PMRGCAuk
1 year ago
new clinical trial Risvodetinib (IkT-148009)
The 201 Clinical Trial For Patients With Untreated Parkinson’s Disease The 201 Clinical Trial is a trial that will explore whether a novel drug, Risvodetinib (IkT-148009), can slow or halt progression of Parkinson’s disease. The trial will also evaluate whether Risvodetinib (IkT-148009) can partially
The 201 Clinical Trial For Patients With Untreated Parkinson’s Disease The 201 Clinical Trial is a trial that will explore whether a novel drug, Risvodetinib (IkT-148009), can slow or halt progression of Parkinson’s disease. The trial will also evaluate whether Risvodetinib (IkT-148009) can partially
Boscoejean
in
Cure Parkinson's
6 months ago
Rasagiline: The Neuroprotective Activities of the Novel Multi-Target Iron-Chelators in Models of Alzheimer’s Disease, ALS and Aging
https://www.mdpi.com/2073-4409/12/5/763/html However, accumulating evidence has shown that iron-dependent oxidative stress (OS), increased iron levels, and monoamine oxidase (MAO)-B activity, as well as reduced antioxidant levels and activities in the brain, maybe major pathogenic factors in neurodegenerative
https://www.mdpi.com/2073-4409/12/5/763/html However, accumulating evidence has shown that iron-dependent oxidative stress (OS), increased iron levels, and monoamine oxidase (MAO)-B activity, as well as reduced antioxidant levels and activities in the brain, maybe major pathogenic factors in neurodegenerative
Hidden
in
Cure Parkinson's
1 year ago
first U.S. patients dosed in expanded Phase 1b clinical trial of CB307 for patients with mCRPC
one step at a time….immune therapy for prostate cancer is becoming hotter! https://finance.yahoo.com/news/crescendo-biologics-announces-first-u-120000112.html
one step at a time….immune therapy for prostate cancer is becoming hotter! https://finance.yahoo.com/news/crescendo-biologics-announces-first-u-120000112.html
Maxone73
in
Advanced Prostate Cancer
6 months ago
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