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Abiraterone
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Role of free testosterone levels in mCRPC.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel,
abiraterone
acetate, enzalutamide, cabozantinib, carboplatin or cabazitaxel.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel,
abiraterone
acetate, enzalutamide, cabozantinib, carboplatin or cabazitaxel.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
ADT + Chemo vs ADT followed by Chemo
This was true in spite of the fact that most of the ADT only men were later treated with chemo once they became castration resistant, and many had
abiraterone
or enzalutamide. In other words, early chemo combined with ADT worked better than late chemo after ADT had stopped working.
This was true in spite of the fact that most of the ADT only men were later treated with chemo once they became castration resistant, and many had
abiraterone
or enzalutamide. In other words, early chemo combined with ADT worked better than late chemo after ADT had stopped working.
AlanMeyer
in
Advanced Prostate Cancer
7 years ago
Blacks Respond Better Than Whites...When Treated For mCRPC with Zytiga
https://www.urotoday.com/recent-abstracts/urologic-oncology/mcrpc-treatment/93775-prostate-specific-antigen-response-in-black-and-white-patients-treated-with-
abiraterone
-acetate-for-metastatic-castrate-resistant-prostate-cancer.html
https://www.urotoday.com/recent-abstracts/urologic-oncology/mcrpc-treatment/93775-prostate-specific-antigen-response-in-black-and-white-patients-treated-with-
abiraterone
-acetate-for-metastatic-castrate-resistant-prostate-cancer.html
gusgold
in
Advanced Prostate Cancer
7 years ago
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Maximum Hormone Blockade
She told me that for me, the treatment is Zolodex, until it stops working, followed shortly by Docetaxel, Xtandi/
Abiraterone
. When I questioned her about whether this was the best course of action, she got quite short with me, "get back in your box - I'm the expert" attitude.
She told me that for me, the treatment is Zolodex, until it stops working, followed shortly by Docetaxel, Xtandi/
Abiraterone
. When I questioned her about whether this was the best course of action, she got quite short with me, "get back in your box - I'm the expert" attitude.
paulofaus
in
Advanced Prostate Cancer
7 years ago
Inflammation. [1] Neutrophil-to-Lymphocyte Ratio [NLR]
The median {overall survival} was 10.4 months ... in patients with baseline NLR >3 and 16.9 months ... in those with baseline NLR ≤3 ..." [9] Zytiga (
Abiraterone
acetate) [9a] "SII and NLR might represent an early and easy prognostic marker in mCRPC patients treated with
abiraterone
."
The median {overall survival} was 10.4 months ... in patients with baseline NLR >3 and 16.9 months ... in those with baseline NLR ≤3 ..." [9] Zytiga (
Abiraterone
acetate) [9a] "SII and NLR might represent an early and easy prognostic marker in mCRPC patients treated with
abiraterone
."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
PSMA imaging in prostate cancer
The toxicity seems to be low. " "... a survival benefit over approved standard therapies such as
abiraterone
, enzalutamide, radium-223-dichloride, docetaxel or cabazitaxel has not been shown.
The toxicity seems to be low. " "... a survival benefit over approved standard therapies such as
abiraterone
, enzalutamide, radium-223-dichloride, docetaxel or cabazitaxel has not been shown.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
High Dose Testosterone as a treatment for the AR-V7 Blocking of Xtandi and Zytiga
Gus http://www.hematologyandoncology.net/index.php/archives/may-2016/current-understanding-of-resistance-to-
abiraterone
-and-enzalutamide-in-advanced-prostate-cancer/
Gus http://www.hematologyandoncology.net/index.php/archives/may-2016/current-understanding-of-resistance-to-
abiraterone
-and-enzalutamide-in-advanced-prostate-cancer/
gusgold
in
Advanced Prostate Cancer
7 years ago
Arbireterone and/or chemo
I have read a lot about
abiraterone
(zytiga) in the last few days. Does anyone know if this is now widely available to men in the UK (if the Drs believe it might be helpful) and if so does it tend to be given before or after chemo.
I have read a lot about
abiraterone
(zytiga) in the last few days. Does anyone know if this is now widely available to men in the UK (if the Drs believe it might be helpful) and if so does it tend to be given before or after chemo.
Sallyyy
in
Advanced Prostate Cancer
8 years ago
presciption names
you know how the same prescription can be sold by different names... i'm on prednisone and
abiraterone
is that similar to xtandi or zytiga ?
you know how the same prescription can be sold by different names... i'm on prednisone and
abiraterone
is that similar to xtandi or zytiga ?
joeoconnell
in
Advanced Prostate Cancer
8 years ago
History of my journey
Abiraterone
(had to come off for toxicity reasons), Enzalutamide and now cabazitaxel.
Abiraterone
(had to come off for toxicity reasons), Enzalutamide and now cabazitaxel.
HughVG
in
Fight Prostate Cancer
8 years ago
Taking Xytiga (Abiraterone) with food.
Has anyone experience of taking
Abiraterone
with food? All advice welcome. Niall
Has anyone experience of taking
Abiraterone
with food? All advice welcome. Niall
NiallMcC
in
Advanced Prostate Cancer
8 years ago
Indomethacin / Xtandi
"The introduction of enzalutamide and
abiraterone
has led to improvement in the treatment of metastatic castration-resistant prostate cancer. However, acquired resistance to enzalutamide and
abiraterone
therapies frequently develops within a short period in many patients.
"The introduction of enzalutamide and
abiraterone
has led to improvement in the treatment of metastatic castration-resistant prostate cancer. However, acquired resistance to enzalutamide and
abiraterone
therapies frequently develops within a short period in many patients.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Predictors of duration of Zytiga in men with CRPC.
In multivariable analysis, duration of primary ADT (duration of
abiraterone
9 versus 13 months for ⩽12 versus >12 months ...) and no use of prior chemotherapy (duration of
abiraterone
16 versus 7 months for no versus yes prior chemotherapy ...) were associated with duration of
abiraterone
."
In multivariable analysis, duration of primary ADT (duration of
abiraterone
9 versus 13 months for ⩽12 versus >12 months ...) and no use of prior chemotherapy (duration of
abiraterone
16 versus 7 months for no versus yes prior chemotherapy ...) were associated with duration of
abiraterone
."
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Foods/Supplements-Vitamins: Hormones - Progesterone
Zytiga (
abiraterone
acetate) inhibits 17α-hydroxylase, which takes Preg --> 17α-hydroxyPreg, & Prog --> 17α-hydroxyProg. It also inhibits 17,20-lyase, which takes 17α-hydroxyPreg --> DHEA, & 17α-hydroxyProg --> androstenedione.
Zytiga (
abiraterone
acetate) inhibits 17α-hydroxylase, which takes Preg --> 17α-hydroxyPreg, & Prog --> 17α-hydroxyProg. It also inhibits 17,20-lyase, which takes 17α-hydroxyPreg --> DHEA, & 17α-hydroxyProg --> androstenedione.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Galeterone for the treatment of advanced prostate cancer: the evidence to date
Meanwhile, additional Phase II trials are being planned using galeterone in the post-
abiraterone
and post-enzalutamide populations.
Meanwhile, additional Phase II trials are being planned using galeterone in the post-
abiraterone
and post-enzalutamide populations.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Cost-savings analysis of AR-V7 testing in mCRPC patients eligible for treatment with abiraterone or enzalutamide
METHODS: We calculated the cost savings of performing AR-V7 testing in mCRPC patients prior to starting
abiraterone
/enzalutamide (and avoiding these drugs in AR-V7(+) men) versus treating all mCRPC patients empirically with
abiraterone
/enzalutamide (without use of the biomarker).
METHODS: We calculated the cost savings of performing AR-V7 testing in mCRPC patients prior to starting
abiraterone
/enzalutamide (and avoiding these drugs in AR-V7(+) men) versus treating all mCRPC patients empirically with
abiraterone
/enzalutamide (without use of the biomarker).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer.
Despite major initial therapeutic success, the strategies of long term anti-hormone therapies with either tamoxifen or aromatase inhibitors (AI) or antiandrogens or
abiraterone
for breast and prostate cancer, respectively, eventually lead to a significant proportion of anti-hormone resistant or stimulated
Despite major initial therapeutic success, the strategies of long term anti-hormone therapies with either tamoxifen or aromatase inhibitors (AI) or antiandrogens or
abiraterone
for breast and prostate cancer, respectively, eventually lead to a significant proportion of anti-hormone resistant or stimulated
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Glenn from mississauga ont canada with advanced prostate cancer
- 2011 bang advanced prostate cancer out of the blue at 54 - gleason 9.5 mets to hips and spine, in lympnodes - tried most things zoledex,
abiraterone
(Zytiga®), Docetaxel (Taxotere®) Cabazitaxel (Jevtana®), radium 223, Enzalutamide, xgeva,zometa, - on my 3rd round of chemo Docetaxel and Carbplatin
- 2011 bang advanced prostate cancer out of the blue at 54 - gleason 9.5 mets to hips and spine, in lympnodes - tried most things zoledex,
abiraterone
(Zytiga®), Docetaxel (Taxotere®) Cabazitaxel (Jevtana®), radium 223, Enzalutamide, xgeva,zometa, - on my 3rd round of chemo Docetaxel and Carbplatin
glennporemba
in
Advanced Prostate Cancer
8 years ago
Significance of early PSA response.
KEYWORDS:
Abiraterone
; Enzalutamide; PSA; Prostate cancer PMID: 27151554 [PubMed - as supplied by publisher]
KEYWORDS:
Abiraterone
; Enzalutamide; PSA; Prostate cancer PMID: 27151554 [PubMed - as supplied by publisher]
pjoshea13
in
Advanced Prostate Cancer
8 years ago
My History
Have been on combined Zoladex and
Abiraterone
more or less since the beginning and a bone scan 7 months ago revealed a reduction of maybe 40 to 60% metasteses. At that stage my PSA which had gone down to 0.1 had risen to 3.6 and I have just completed a 6 month course of Radium 223 infusions.
Have been on combined Zoladex and
Abiraterone
more or less since the beginning and a bone scan 7 months ago revealed a reduction of maybe 40 to 60% metasteses. At that stage my PSA which had gone down to 0.1 had risen to 3.6 and I have just completed a 6 month course of Radium 223 infusions.
NiallMcC
in
Advanced Prostate Cancer
8 years ago
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