Help with blood test results please: Hi everyone... - Thyroid UK

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Help with blood test results please

DeltaD profile image
8 Replies

Hi everyone,

This is my first post and I’ve just had my results sent through from Medichecks and I’m wondering if anyone could help advise me of which supplements I should take?

Ferritin 86.8 (30-150)

Folate serum 18.6 (8.83-60.8)

Vitamin B12 active (93.5 (37.5-188)

Vitamin D 61.9 (50-250)

TSH 1.65 (0.27-4.2)

Free T3 4.2 (3.1-6.8)

Free thyroxine 16.8 (12-22)

Thyroglobulin Antibodies 33 (0-115)

Thyroid Peroxide Antibodies 528 (0-34)

I had an appointment with the GP last week who has agreed to give me a trial on a higher dose of Levothyroxine as I’m still very tired, cold, brain fog and my memory is dreadful.

The only test done by the GP this time was TSH which was 1.75 and I was on 75 a day and have now been prescribed 100, although it was made clear that this is just a trial and it depends on my next TSH blood results in 8 weeks as my result was within range.

I used to take a multivitamin and Vitamin D tablet every day but stopped around 3 weeks ago as I was getting the Medichecks test done and would now like to start taking some decent supplements in the hope of feeling better so I’m hoping someone will be able to advise me, thanks 😊

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SlowDragon profile image
SlowDragonAdministrator

welcome to the forum

Which brand were you taking for 75mcg

Which brand for 100mcg

Was test done early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

FT4: 16.8 pmol/l (Range 12 - 22)

Ft4 only 48.00% through range

FT3: 4.2 pmol/l (Range 3.1 - 6.8)

Ft3 only 29.73% through range

Helpful calculator for working out percentage through range

thyroid.dopiaza.org

How much vitamin D have you been taking

obviously dose needs to increase

GP will often only prescribe to bring vitamin D levels to 50nmol.

Some areas will prescribe to bring levels to 75nmol or even 80nmol

leedsformulary.nhs.uk/docs/...

GP should advise on self supplementing if over 50nmol, but under 75nmol (but they rarely do)

mm.wirral.nhs.uk/document_u...

But with Hashimoto’s, improving to around 80nmol or 100nmol by self supplementing may be better

pubmed.ncbi.nlm.nih.gov/218...

vitamindsociety.org/pdf/Vit...

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly via NHS private testing service when supplementing

vitamindtest.org.uk

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function.

There’s a version made that also contains vitamin K2 Mk7.

One spray = 1000iu

amazon.co.uk/BetterYou-Dlux...

It’s trial and error what dose we need, with thyroid issues we frequently need higher dose than average

Vitamin D and thyroid disease

grassrootshealth.net/blog/t...

Vitamin D may prevent Autoimmune disease

newscientist.com/article/23...

Web links about taking important cofactors - magnesium and Vit K2-MK7

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Interesting article by Dr Malcolm Kendrick on magnesium

drmalcolmkendrick.org/categ...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

B vitamins

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Other options

healthunlocked.com/thyroidu....

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg)

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

SlowDragon profile image
SlowDragonAdministrator

High TPO antibodies confirms autoimmune thyroid disease also called Hashimoto’s

GP should have done coeliac blood test at diagnosis

Have they?

nice.org.uk/guidance/ng20/c...

1.1 Recognition of coeliac disease

1.1.1 Offer serological testing for coeliac disease to:

people with any of the following:

persistent unexplained abdominal or gastrointestinal symptoms

faltering growth

prolonged fatigue

unexpected weight loss

severe or persistent mouth ulcers

unexplained iron, vitamin B12 or folate deficiency

type 1 diabetes, at diagnosis

autoimmune thyroid disease, at diagnosis

irritable bowel syndrome (in adults)

first‑degree relatives of people with coeliac disease.

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten.

Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first or buy test online for under £20, just to rule it out first

Assuming test is negative you can immediately go on strictly gluten free diet 

(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially) 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

Post discussing gluten

healthunlocked.com/thyroidu...

DeltaD profile image
DeltaD in reply to SlowDragon

Hi SlowDragon thanks for replying,

I take mainly TEVA brand although when my dose was put up from 50-75 the last time I was given some of the 25’s made by Wockhardt, I just have to accept what the chemist have in stock at the time - my test was at 9am and it would have been about 25 hours after my last dose of levothyroxine.

I was just taking generic vitamin D’s, the last ones were by Revitalise healthcare, one a day 25ug but I’ll look into getting the spray and B complex you have suggested.

As far as I’m aware I’ve not had a coeliac test although I had to have a colonoscopy last year and was diagnosed with diverticular disease also I suffer from IBS so maybe a gluten free diet would be worth a try.

I’ll go and have a look at all the links you have kindly attached for me.

Thanks 😊

SlowDragon profile image
SlowDragonAdministrator in reply to DeltaD

25ug vitamin D is only 1000iu

Many members find they need at least 3000iu vitamin D daily

Vitamin D tablets you swallow should be at least 4 hours away from levothyroxine

Vitamin D mouth spray can be only an hour away

Magnesium supplements best at bedtime, or at least 4 hours before if you take levothyroxine at bedtime

DeltaD profile image
DeltaD in reply to SlowDragon

Oh I never realised I should wait 4 hours for vitamin D, I normally took it about an hour after the levothyroxine!

I’ve now ordered the Better you D3000+K2 spray, Igennus Super B complex and Zipvit Magnesium 500mg from Amazon and it’s all due to arrive tomorrow, so I’ll get started on them.

I’m not sure if I notice any difference with the Levothyroxine brands, I have what I call a funny stomach anyway but not aware if it’s any different when mixing brands, currently I’m mixing both to make up my dose but I’ll try paying more attention to it.

I’m also going to start cutting down gluten in my diet although I have a fair amount of gluten foods to get through so will start gradually and work up to a trial of gluten free, I didn’t realise how many different things are affected by thyroid problems!

Once again thanks for taking the time to reply 😊

Mixteca profile image
Mixteca in reply to DeltaD

I take health leads D3 4000iu capsules. I was very deficient years ago and my levels gradually rose on 2000iu. I doubled that and it went up much quicker and reached 141.9 nmol/L, so I now take it on alternate days as a maintenance dose.

DeltaD profile image
DeltaD in reply to Mixteca

Hi Mixteca,

I used to just buy the inexpensive vitamin D from whichever shop I happened to be in but I know realise that you probably get what you pay for.

I’ve ordered the Better you 3000+K2 spray and I’ll get my levels checked again in a few weeks but I’ll bear in mind your suggestion if it’s taking a long time for my levels to rise, that’s also a good idea taking it alternate days to maintain your levels as probably more cost effective than taking a smaller dose daily.

Thanks for replying 😊

SlowDragon profile image
SlowDragonAdministrator

Different brands of levothyroxine

Many people find Levothyroxine brands are not interchangeable.

If you struggle with different brands GP can/should specify brand you do best with

Most easily available (and often most easily tolerated) are Mercury Pharma or Accord

Mercury Pharma make 25mcg, 50mcg and 100mcg tablets 

Mercury Pharma also boxed as Eltroxin. Both often listed by company name on pharmacy database - Advanz

Accord only make 50mcg and 100mcg tablets. Accord is also boxed as Almus via Boots, 

Wockhardt is very well tolerated, but only available in 25mcg tablets. Some people remain on Wockhardt, taking their daily dose as a number of tablets 

Lactose free brands - currently Teva or Vencamil only

Teva makes 25mcg, 50mcg, 75mcg and 100mcg

Many patients do NOT get on well with Teva brand of Levothyroxine.

Teva is lactose free.But Teva contains mannitol as a filler instead of lactose, which seems to be possible cause of problems. Mannitol seems to upset many people, it changes gut biome 

Teva is the only brand that makes 75mcg tablet.

So if avoiding Teva for 75mcg dose ask for 25mcg to add to 50mcg or just extra 50mcg tablets to cut in half

But for some people (usually if lactose intolerant, Teva is by far the best option)

Aristo (currently 100mcg only) is lactose free and mannitol free.

March 2023 - Aristo now called Vencamil

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

List of different brands available in U.K.

thyroiduk.org/if-you-are-hy...

Posts that mention Teva

healthunlocked.com/search/p...

Teva poll

healthunlocked.com/thyroidu...

Once you find a brand that suits you, best to make sure to only get that one at each prescription.

Watch out for brand change when dose is increased or at repeat prescription.

Government guidelines for GP in support of patients if you find it difficult/impossible to change brands

gov.uk/drug-safety-update/l...

If a patient reports persistent symptoms when switching between different levothyroxine tablet formulations, consider consistently prescribing a specific product known to be well tolerated by the patient.

academic.oup.com/jcem/artic...

Physicians should: 1) alert patients that preparations may be switched at the pharmacy; 2) encourage patients to ask to remain on the same preparation at every pharmacy refill; and 3) make sure patients understand the need to have their TSH retested and the potential for dosing readjusted every time their LT4 preparation is switched (18).

And here

pharmacymagazine.co.uk/clin...

Discussed here too

healthunlocked.com/thyroidu...

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