I had a strange situation years ago where my FT4 and Ft3 were all normal, my TSH was 3.7 but my Liver enzymes were elevated over range. It turned out that the actual levels of thyroxine in my body were too high. The only test that revealed this was the Total T4 or thyroxine test. I felt terrible at the time too. So the only medication that has ever elevated my liver enzymes is Levothyroxine.
I have the same problem with ALP(140) mine seems to go up with taking T3. I am only taking 75T4 and 15T3, still feeling hypo! I need both T3/4 as I have Dl01 and D102 genes. ALP has been high for years..
Hi.I know you said you had liver blood tests. Do you know if they tested AMA, (antimitocondrial antibodies). It is specific for PBC, Primary billary cholangitis.
I have this and lfts were high. I also have hypothyroidism, they can go together.
I have recently been diagnosed with a fatty liver after having pain and bloating in right side just under the rib. Apparently very common in hyper and hypothyroid. Mine started after I had RAI for graves. I found taking lactose free levo helped and no drinking alcohol and I started to do the mediterranean diet. It has helped (though currently not doing so well with the build up to Christmas)Might be worth looking into, plenty of Facebook groups that have helped me if you are on Facebook.
I can’t afford the liposomal glutathione but have NAC solgar and colon therapist who is a nutritionist told me to take this and milk thistle. I have been taking high doses of milk thistle until last week . Just the alp is rising .
I have annual private medical, which gives results that no way can get from GP. Last winter my liver enzymes were worringly high, but had been quite ill and had taken medication. This winter medical showed enzymes back to normal...strange!Also, have struggled with 'flabby' legs for years. Tried cellutite creams, vigorous brushing. Only thing I find work, depressingly! is swimming, speedwalking, and intermittent fasting.All makes me , yes, feel better, increases mood...but bloody knackered!
Oh goodness I have just come to the conclusion that being hypothyroid (in my case) gives us all ‘unknowns’ until we know! I had a number of symptoms which dogged me for years before medication (including liver investigations - all clear) and I have picked up some new symptoms since embarking on medication. Have you been ill recently? Even constipation can cause pain that high up the gastro intestinal tract. Diverticulitis same, although usually felt lower down. Muscles cramping can give the impression of gall bladder dysfunction, be acute and chronic and pretty painful. Medication may be changing things in the body - hopefully for some improvement. The liver is very much associated with ‘metabolism’. Thyroid is a big metabolism problem. And cholesterol off course. My cholesterol has dropped 3.1 points for no other reason than my thyroxine - after years of docs trying to put me on statins. Honestly, how do you feel? If generally better that’s good BUT never be afraid of following things up if you are unsure.
added a query, but for some reason it did not post! Did they definitely check your bile duct in ultrasound? I had pain in right under ribs, given antibiotics for a week, which unsurprisingly did nothing, then another GP tested bloods and found ( I think I remembering correctly from about 7 years ago) raised ALT/ALP, and I was going a bit yellow. An ultrasound saw it was blocked… procedure found sludge, rather than one big gallstone. All a thyroid disease side effect! Worth asking to see ultra sound checked little duct, not just huge liver.
I've had elevated Alkaline Phosphatase that my doctor claimed was due to being hyperthyroid even though thyroid labs were in range. I started taking Pure Encapsulations Silymarin (milk thistle) for liver detox and Alkaline Phosphatase dropped from 167 to 143. Range is 44-121 I/UL. I'll test again soon and see if it's in range.
funny I take milk thistle and NAC and stopped for a week - Just read milk thistle lowers thyroid so stopped it balancing it out. Took milk thistle last night high dose and got a bowel movement - no idea if coincidence .
is very sad no hope for me ferritin, folate, liver enzymes still sure i got liver issues as had high bilirubin n high b12 - stopped T3 years ago doctors refused me 5mg told me so bad i wud just need sleepn i must have some other hystamine or mast cell or hormone as my bladder bad now pelvic pain etc
You should create a new post and tell us your vitamin and mineral levels as well as your thyroid hormone levels. Optimising all of these will most likely have a good effect on the health of your liver.
Both untreated/mismanaged hypERthyrodiism and hypOthyroidism can cause elevated liver enzymes but also any large change in thyroid hormone levels. If you are not over medicated on T3 you may find enzymes normalise.
NAC is great as much cheaper and the precursor to glutathione. I take it too.
helvella’s reply offered information about the risk of milk thistle altering thyroid hormone transporters so disabling the hormones ability to travel around your body. I’m an advocate of milk thistle but would never take large doses as you have stated twice in your post. Maybe try reducing a little 😊
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