Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

[helvella]

This is another paper about the possibility of effectively re-growing thyroid glands.

I've had a quick read (it has lots of complex detail so it very hard going).

The issue not addressed, so far as I can see, is the applicability of this approach in those with the predominant thyroid disease - Hashimoto's. Unless there is a way of stopping destructive processes, what benefit?

Yes, of course, it has lots of potential in those who have no thyroid for other reasons.

• Article Open Access Published: 17 November 2022

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Mírian Romitti,

Adrien Tourneur,

Barbara de Faria da Fonseca,

Gilles Doumont,

Pierre Gillotay,

Xiao-Hui Liao,

Sema Elif Eski,

Gaetan Van Simaeys,

Laura Chomette,

Helene Lasolle,

Olivier Monestier,

Dominika Figini Kasprzyk,

Vincent Detours,

Sumeet Pal Singh,

Serge Goldman,

Samuel Refetoff &

Sabine Costagliola

Nature Communications volume 13, Article number: 7057(2022) Cite this article

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Abstract

The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development.

Open access here:

nature.com/articles/s41467-...

[nightingale-56]

After a sub-total (9/10ths) thyroidectomy in 1981, my thyroid gland was found to have grown again by approx. 2005, but, unfortunately it is not working again. This is not something that I would like to chance unless there was a guarantee of it working properly again. Thanks for posting helvella .

[diogenes Remembering]

The real problem is: even if the stem cells produce a thyroid in situ, will it respond properly to a stimulating factor like TSH. Suppose a patient has been without a thyroid for some time, on treatment. Then we can be sure that there will be a long lag before the TSH begins to behave properly, as it has shrivelled up. The longer a patient has been on treatment, then recovery is much more difficult. Also, it's a bit of a "one step and Jack is free" thinking. When we developed from foetuses, the emerging body matured in a specific way, with specific time periods for each corporeal item to develop in harmony with others. The question is whether a new thyroid can seamlessly integrate into the patient's depleted system. I think it will a long time before this is tried on humans.

[shaws Administrator in reply to diogenes]

Thank you for your response diogenes.

[chrisbuy63]

I wonder if they are taken from living baby cells or from aborted fetus, it would be a deciding factor for me as a Christian and pro life.