Hello there,
I have been doing research recently and i came across something that may interest some of you. So i read the following study
jstage.jst.go.jp/article/tj...
To summarise it basically says aspirin helps with thyroid hormone conversion. So what does aspirin do?
Aspirin helps with headaches by blocking COX 1 and 2 which prevents prostaglandins being created from the release of lipase. so perhaps this is what contributes to some thyroid symptoms.
now i hypothesised that omega 6 is at fault as theres a few short-term studies with omega 3 showing a similar pattern (insignificant increases).
I read the following study pubmed.ncbi.nlm.nih.gov/258...
which talks about the 20-hydroxyeicosatetraenoic acid(20-HETE) and suggests it could contribute to hypertension in particular with hyperthyroid patients.
now what happens when we eat linoleic acid is its converted into arachidonic acid by D5D and D6D. This is later metabolised by cytochrome p450. A metabolite produced is this acid 20-HETE. It positively correlated with thyroid hormone levels as stated in the previous study. Furthermore, there's a lignan in sesame which has been used to treat thyroid cancer shown here link.springer.com/article/1...
this just happens to be an inhibitor of the 20-HETE so it ties in nicely with the theory but doesnt necessarily prove it the below study shows TSH reduced and T4 increases with lignans, they didn't measure T3 but I suspect it has increased also
so perhaps this could help in part with thyroid diseases ? let me know your thoughts if you have anything to add.