low tsh,t3,t4. low sex hormones too. - Thyroid UK

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low tsh,t3,t4. low sex hormones too.

hypossee profile image
6 Replies

Hi. so I don't think I'll ever feel better at this point but I'm still going to try as much as I can. I still have symptoms but not AS BAD as it used to be. I honestly don't have a proper set of words to put out here as to what I'm trying to ask but here's my blood report from May 11. The following blood report is from the time when I was on 90 mg np thyroid.

tsh 5.60 MIU/ML

0.32-4.0 MIU/ML

ft3 2.8 (2.3-4.2)

ft4

0.81 NG/DL

(0.71-1.85 NG/DL)

After the above blood report I was put on 120 mg of Np thyroid for 6 weeks and got the following result:

Free Thyroxine

(ft4)

0.84 NG/DL

range:0.71-1.85 NG/DL

TSH 3rd Generation

0.89 MIU/ML

range:0.32-4.0 MIU/ML

Free Triiodothyronine

2.9pg/mL

range:2.3-4.2 pg/mL

Why is my t3 not increasing significantly? I requested my doctor to lower my np thyroid to 105 mg and add t3 to my medication protocol But I do not know if that's going to help. I'm a 24-year-old guy and I have all sorts of problems because of this and I don't seem to get any conclusion as to what I should even attempt doing. I am even paying an integrated medicine doctor out of pocket but something is not quite working well enough( it definitely is to one extent, way better than my doctor that takes my insurance and does nothing).

My integrated medicine doctor checked my hormones too and it looks like they are low too so now he has put me on compounded TRT cream along with DIM. Below are my results:

TESTOSTERONE, FREE1 104.8 pg/mL 46.0-224.0

DHEA SULFATE2 345 mcg/dL 85-690

TESTOSTERONE, TOTAL, MALES (ADULT), IA2 542 ng/dL 250-827

SEX HORMONE BINDING GLOBULIN2 20 nmol/L 10-50

DIHYDROTESTOSTERONE, LC/MS/MS3 25 ng/dL 16-79

DHT, FREE3 2.12 pg/mL

ESTRADIOL, ULTRASENSITIVE LC/MS/MS3 33 pg/mL < OR = 29

What is happening to me? I'm going through this for quite a few years now so any reply to this post would be really really appreciated. I'm just trying to pick on any given information at this point and try to consciously contextualize in my favor in however way possible. Thank you so much for taking your time. Really.

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6 Replies
greygoose profile image
greygoose

2 grains of NDT isn't much of a dose. It only contains 18 mcg T3. Why don't you try increasing your dose of NDT? Your FT4 is low, too.

It's not surprising that your sex hormones are low, because hormones are all inter-dependant, and when one is out of kilter, the others are going to be, too. How's your cholesterol? You aren't taking statins, are you? Nothing more guaranteed to lower sex hormones than taking statins! :)

Have you had your nutrients tested? Vit D, vit B12, folate and ferritin?

Caesard profile image
Caesard in reply to greygoose

I agree with greygoose, it looks like you not on optimal levels in your treatment.

My understanding is that you do have your own thyroid but, looking at your HRT level, I would say that though is significant for people retaining own thyroid function yet is signalling as insufficient, from both symptom relief, specific tests result and systemic effects - the sex hormones. Are there any autoimmune issues with your thyroid? What is the base condition affecting it?

Regardless of that, it looks that you should go up in increments spread over a minimum of 8-12 weeks.

Also, should be checked relevant vitamins & minerals, as advised above; have you had cortisol and ACTH function assessed as well?

In respect to the sex hormones I can relate personally, I have been there. I don't really know when the decrease started but tend to associate with hypothyroidism timing, though I wouldn't exclude that the process started together with the thyroid burning one.

Over the last 2 years I have managed to stabilise the thyroid function and doubled the free testosterone level, mainly via the effect of stable thyroid function, exercise (lifestyle) and supplements (amino-acids, vitC & Zn - very important, vit D, Mg, B6, B12)

I can confirm that free testosterone doesn't need to be very low (it can be well within limit) in order to make one miserable.

hypossee profile image
hypossee in reply to Caesard

thanks for your reply caesard. my antibodies are high but way better than before (it was over 500)

Thyroid Peroxidase Antibodies

38 IU/mL

range = <9 IU/mL (H)

all my vitamins and minerals are in good condition since I really have worked on it for the past 1.5 years. I did the cortisol test as well( the saliva test throughout the day) and it came out normal except for the night one. At night, it showed a little higher than the given range. ACTH is good too.

Adrenocorticotropic Hormone

29 pg/mL

(6-50 pg/mL)

I have completely removed gluten from my diet as well. I'm just hoping that the added 5mg Cytomel would make the progress a little better

Caesard profile image
Caesard in reply to hypossee

Looks good!

It is my (non- professional) opinion that 5mg T3 extra is not enough but you could increment on more or less similar steps (e.g. 25 T4 & 5 T3)

Higher in range T4 is important as well, especially if your conversion is reasonable. From my own experience, a FT4 decrease, triggered by lessening of T4 input, brought immediate symptom manifestation increase. Therefore, in my case, where I use a T4/T3 combo ( currently 137.5 T4 and 27.5 T3 - I had my thyroid removed, so 0 natural function) the T4 manifests as important as the T3, provided that my conversion seems reasonably effective, though on T4 only I was oscillating between a functional and a crash state.

When using T3 the TSH drops to suppressed levels, due to T3 effect on The feedback loop closed by TSH.

However, this doesn't necessarily means hyper and hyper symptoms. Yet again, this seems to be relative from person to person.

I am functioning pretty good on a suppressed TSH for some time now, but I do monitor FT3 and FT4, as well as core temperature and rest heart rate, guided by symptom relief.

It's trial and error, or at least that was for me.

hypossee profile image
hypossee in reply to greygoose

Thanks a lot for your reply. My cholesterol is good but i don't have the levels for that. i also dont take any statins. My doctor just added t3 to my np thyroid. He now wants me to take 120 mg of np thyroid with 5 mg t3. I have also heard that t4 doesn't matter as much when you're taking ndt and t3, is that true?

vit d - 75

vit b12:2000

folate :13

ferritin:43

magnesium: 5.0 (4.0-5.8)

My ferritin, no matter what, doesn't seem to increase at this point. I've been doing everything for it but still doesn't work.

do you think adding 5mg t3 to 120 mg ndt is a good idea? or is 5mg too low? Also, I think that if I were to increase the dose from 120 mg to 135 or 150mg, it would lower my tsh way too much and would make me hyper but i might be wrong. thanks again greygoose

in reply to hypossee

I'm 68 and have been dealing with testosterone and thyroid issues for nearly a decade so I understand how miserable it has to be for someone over four decades younger. My only observation is that there might be a pituitary malfunction which would account for low T and hypothyroid symptoms. One possibility is central hypothyroidism. The way it's treated is to keep titrating thyroid until most or all symptoms resolve. Another way to establish pituitary involvement is a blood test for prolactin. If it was over range, it could indicate a microadenoma on the pituitary. To confirm, your doctor would have to order an MRI. I'm not a medical professional; just an obsessive explorer seeking to restore my health and life. You keep working at it!

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