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Cost-savings analysis of AR-V7 testing in mCRPC patients eligible for treatment with abiraterone or enzalutamide
This seems to say that the presence of any AR-V7 at all should rule out Zytiga &
Xtandi
. But what if only a small percent of one's PCa cells were AR-V7 positive? AR-V7 can be present at an early stage - certainly before CRPC. $1,000 is such a nice round number. I wonder what the true cost is?
This seems to say that the presence of any AR-V7 at all should rule out Zytiga &
Xtandi
. But what if only a small percent of one's PCa cells were AR-V7 positive? AR-V7 can be present at an early stage - certainly before CRPC. $1,000 is such a nice round number. I wonder what the true cost is?
pjoshea13
in
Advanced Prostate Cancer
8 years ago
What comes after Zytiga and Xtandi have failed?
After that I was put on Zytiga and
Xtandi
together in a clinical trial which only reduced my PSA to 53 at the lowest point but after 8 months my PSA has risen to 82 and new legions have been found so I was kicked out of the clinical trial.
After that I was put on Zytiga and
Xtandi
together in a clinical trial which only reduced my PSA to 53 at the lowest point but after 8 months my PSA has risen to 82 and new legions have been found so I was kicked out of the clinical trial.
sinjonn
in
Advanced Prostate Cancer
8 years ago
Foods/Supplements-Vitamins: Berberine
mesenchymal genes that regulate the developmental EMT." [2j] (2015 - China) "Berberine inhibits the proliferation of prostate cancer cells and induces G₀/G₁ or G₂/M phase arrest at different concentrations." [2k] (2016 - China) I posted on aldo-keto reductase 1C3 (AKR1C3) a few days ago (in Indomethacin /
Xtandi
mesenchymal genes that regulate the developmental EMT." [2j] (2015 - China) "Berberine inhibits the proliferation of prostate cancer cells and induces G₀/G₁ or G₂/M phase arrest at different concentrations." [2k] (2016 - China) I posted on aldo-keto reductase 1C3 (AKR1C3) a few days ago (in Indomethacin /
Xtandi
pjoshea13
in
Advanced Prostate Cancer
8 years ago
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Zytiga vs. Xtandi vs. Radium 223 vs. Cannabis
The effectiveness and safety of
Xtandi
were demonstrated in a clinical trial that included 1,199 men who were given either
Xtandi
or placebo. Median overall survival among men who took
Xtandi
was 18.4 months compared with the placebo group at 13.6 months.
The effectiveness and safety of
Xtandi
were demonstrated in a clinical trial that included 1,199 men who were given either
Xtandi
or placebo. Median overall survival among men who took
Xtandi
was 18.4 months compared with the placebo group at 13.6 months.
Gultch
in
Advanced Prostate Cancer
8 years ago
Galeterone for the treatment of advanced prostate cancer: the evidence to date
Resistance to Enzalutamide (
Xtandi
) and Abiraterone (Zytiga) is often associated with the emergence of, & selection for, the androgen receptor splice variant AR-V7. This is a functional receptor that has no need of an androgen ligand.
Resistance to Enzalutamide (
Xtandi
) and Abiraterone (Zytiga) is often associated with the emergence of, & selection for, the androgen receptor splice variant AR-V7. This is a functional receptor that has no need of an androgen ligand.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Surgery not possible for L1-L2 compression fractures related to tumors
PSA is skyrocketing and because PSA and pain only increased in the 5 months of
Xtandi
, his chance of positive response to zytiga is only about 20%, according to research studies. Any advice on what to do now? Thank you for everyone's thoughtful responses and knowledge all things prostate cancer.
PSA is skyrocketing and because PSA and pain only increased in the 5 months of
Xtandi
, his chance of positive response to zytiga is only about 20%, according to research studies. Any advice on what to do now? Thank you for everyone's thoughtful responses and knowledge all things prostate cancer.
Cancersucks
in
Advanced Prostate Cancer
8 years ago
FIRMAGON INJECTION SITE
HI JOEL MY PSA NOW ON
XTANDI
IS .7 HEADACHES GONE I AM ON LUPRON IM ONCE A MONTH BUT THAT WAS NOT WORKING HOLDING THE PSA DOWN CAN WE SWITCH OVER TO FIRMAGON (DEGARELIX) THERE ARE REPORTS IT COULD FURTHER LOWER PSA WHEN LUPRON DOES NOT PLUS THERE IS LESS INCIDENCES OF HEART ATTACKS HOWEVER I AM CONCERNED
HI JOEL MY PSA NOW ON
XTANDI
IS .7 HEADACHES GONE I AM ON LUPRON IM ONCE A MONTH BUT THAT WAS NOT WORKING HOLDING THE PSA DOWN CAN WE SWITCH OVER TO FIRMAGON (DEGARELIX) THERE ARE REPORTS IT COULD FURTHER LOWER PSA WHEN LUPRON DOES NOT PLUS THERE IS LESS INCIDENCES OF HEART ATTACKS HOWEVER I AM CONCERNED
FGENTILEMD
in
Advanced Prostate Cancer
8 years ago
Testosterone level while taking lupron and xtandi
Has anyone experienced a surge in testosterone while on lupron and
xtandi
? Possibly an increase right before next lupron injection?
Has anyone experienced a surge in testosterone while on lupron and
xtandi
? Possibly an increase right before next lupron injection?
Cancersucks
in
Advanced Prostate Cancer
8 years ago
Foods/Supplements-Vitamins: Apigenin
Anyway, a 2015 paper reported that Casodex &
Xtandi
(both antiandrogens) could resensitize PCa to Taxotere by inhibiting ABCB1 efflux.
Anyway, a 2015 paper reported that Casodex &
Xtandi
(both antiandrogens) could resensitize PCa to Taxotere by inhibiting ABCB1 efflux.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Need guidance: maybe stopping treatment Due to treatment failure
Started
xtandi
4 months ago when PSA was 30. He doesn't want to ever do chemo again and is very resistant to Zytiga because of the concurrent prednisone requirement. Onc wants to try Xofigo and Zytiga now. He received his 3month lupron shot but is considering ceasing all other treatments.
Started
xtandi
4 months ago when PSA was 30. He doesn't want to ever do chemo again and is very resistant to Zytiga because of the concurrent prednisone requirement. Onc wants to try Xofigo and Zytiga now. He received his 3month lupron shot but is considering ceasing all other treatments.
Cancersucks
in
Advanced Prostate Cancer
8 years ago
Strontium to preserve bone integrity
Post radiation 3 years and currently starting
Xtandi
, PSA rising 26. My life pleasure is now limited to playing full court basketball and softball 4-5 times a week. (Would like to add back other pleasures but ADT will likely prevent that.)
Post radiation 3 years and currently starting
Xtandi
, PSA rising 26. My life pleasure is now limited to playing full court basketball and softball 4-5 times a week. (Would like to add back other pleasures but ADT will likely prevent that.)
Live2day
in
Advanced Prostate Cancer
8 years ago
xtandi experience
hi joel I am on
xtandi
now 2 months as you suggested I had headaches from it but now I am able to take 4 tablets daily I will have my psa drawn on june 3 I will let you know the results take care frank
hi joel I am on
xtandi
now 2 months as you suggested I had headaches from it but now I am able to take 4 tablets daily I will have my psa drawn on june 3 I will let you know the results take care frank
FGENTILEMD
in
Prostate Cancer Network
8 years ago
AFTER RADIATION--SUCCESS!
Being on
Xtandi
, with its side effects, especially fatigue, and the fatigue from the radiation, which was overwhelming at times, the radiation fatigue has been diminishing.
Being on
Xtandi
, with its side effects, especially fatigue, and the fatigue from the radiation, which was overwhelming at times, the radiation fatigue has been diminishing.
CERICWIN
in
Prostate Cancer Network
8 years ago
New member: 14 year advanced prostate cancer survivor
Down the line, I may accept
Xtandi
or Zytiga but I have definitely decided to refuse docetaxel chemotherapy or its various equivalents if and when that time comes.
Down the line, I may accept
Xtandi
or Zytiga but I have definitely decided to refuse docetaxel chemotherapy or its various equivalents if and when that time comes.
Hidden
in
Advanced Prostate Cancer
8 years ago
Dr. Myers "Aging With Prostate Cancer"
The antiandrogen Casodex is outclassed by
Xtandi
these days, I suppose. -Patrick
The antiandrogen Casodex is outclassed by
Xtandi
these days, I suppose. -Patrick
pjoshea13
in
Advanced Prostate Cancer
8 years ago
mTOR
The studies that added Casodex might have done better with
Xtandi
. In any case, AR inhibition is essential if PI3K is to be inhibited. A number of non-human studies have occurred that used natural substances: [N1] Ursolic Acid (from Holy Basil, etc.)
The studies that added Casodex might have done better with
Xtandi
. In any case, AR inhibition is essential if PI3K is to be inhibited. A number of non-human studies have occurred that used natural substances: [N1] Ursolic Acid (from Holy Basil, etc.)
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Intermittent Xtandi
Does anyone know the effects of skipping a week here and there of
Xtandi
? Know someone doing this and not informing their oncologist. I wonder how dangerous this is...
Does anyone know the effects of skipping a week here and there of
Xtandi
? Know someone doing this and not informing their oncologist. I wonder how dangerous this is...
Cancersucks
in
Advanced Prostate Cancer
8 years ago
Xtandi side effects
Started
Xtandi
in February and for the first 6 weeks felt no effects that I noticed. Now though, I feel fatigued and lethargic all the time. I know that this is presumably a side effect from the
Xtandi
, but curious if others had a delayed fatigue reaction to it.
Started
Xtandi
in February and for the first 6 weeks felt no effects that I noticed. Now though, I feel fatigued and lethargic all the time. I know that this is presumably a side effect from the
Xtandi
, but curious if others had a delayed fatigue reaction to it.
Scmaggi
in
Advanced Prostate Cancer
8 years ago
Significance of early PSA response.
It looked at data from clinical trials of
Xtandi
, Zytiga & Orteronel in CRPC.
It looked at data from clinical trials of
Xtandi
, Zytiga & Orteronel in CRPC.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
XTANDI & RADIATION FATIGUE
The
Xtandi
has given me a lot of fatigue, along with other side effects, and insomnia, and now with the added effects of the radiation, I seldom have to take Ambien to get to sleep now.
The
Xtandi
has given me a lot of fatigue, along with other side effects, and insomnia, and now with the added effects of the radiation, I seldom have to take Ambien to get to sleep now.
CERICWIN
in
Advanced Prostate Cancer
8 years ago
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