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Xtandi
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More bad news
He’s on Metformin, Lupron,
Xtandi
and now Xgeva. They are taking him off
Xtandi
. Next treatment option Taxotere (if he even does that). I am completely heartbroken! If he does taxotere how much time will this buy him at a Gleason 10 with PSA doubling every 3wks?
He’s on Metformin, Lupron,
Xtandi
and now Xgeva. They are taking him off
Xtandi
. Next treatment option Taxotere (if he even does that). I am completely heartbroken! If he does taxotere how much time will this buy him at a Gleason 10 with PSA doubling every 3wks?
Hidden
in
Advanced Prostate Cancer
6 years ago
Postural instability with xtandi and chemo?
He has been on Lupron for 4 years, and
Xtandi
for 13 months. He finished his 2nd round chemo in May with Cabititaxel. Any else have this happen to them?
He has been on Lupron for 4 years, and
Xtandi
for 13 months. He finished his 2nd round chemo in May with Cabititaxel. Any else have this happen to them?
NWLiving
in
Advanced Prostate Cancer
6 years ago
A.I.-guided Chemo Halts Disease Worsening in Patient with mPRPC, Study Reports
Encouraging result after Zytiga (Abiraterone) failure from Phase1/2 Trial using Artificial Intelligence guided delivery of ZEN-3694 and
Xtandi
(Enzalutamide). http://prostatecancernewstoday.com/2018/09/13/artificial-intelligence-guided-chemo-halts-worsening-metastatic-prostate-cancer-patient/
Encouraging result after Zytiga (Abiraterone) failure from Phase1/2 Trial using Artificial Intelligence guided delivery of ZEN-3694 and
Xtandi
(Enzalutamide). http://prostatecancernewstoday.com/2018/09/13/artificial-intelligence-guided-chemo-halts-worsening-metastatic-prostate-cancer-patient/
Moespy
in
Advanced Prostate Cancer
6 years ago
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Shorter time castrate resistant = Zytiga and Xtandi will last even less than first line ADT?
Not always the case, my father became castrate resistant in 2 months with Casodex but is currently on almost his 5th month on Zytiga and doing well so far, so if you fail first line ADT it doesn't necessarily mean that 2nd line ADT will last less. Every patient is unique and responds differently to different
Not always the case, my father became castrate resistant in 2 months with Casodex but is currently on almost his 5th month on Zytiga and doing well so far, so if you fail first line ADT it doesn't necessarily mean that 2nd line ADT will last less. Every patient is unique and responds differently to different
Dalph87
in
Advanced Prostate Cancer
6 years ago
Long term opiod effects
His treatment, now
Xtandi
, Eligard, and Xgeva, seems to be working well right now. He’s been on 50mmg fentanyl and hydrocodone for 2+ years. He is sleeping more and more during the day and is more depressed lately. He takes a low dose anti-depressant.
His treatment, now
Xtandi
, Eligard, and Xgeva, seems to be working well right now. He’s been on 50mmg fentanyl and hydrocodone for 2+ years. He is sleeping more and more during the day and is more depressed lately. He takes a low dose anti-depressant.
Bball
in
Advanced Prostate Cancer
6 years ago
Dad declining fast
Two weeks ago my dad found out that his PSA jumped from 3.5 to 10 in four weeks on
Xtandi
. He had only been on
Xtandi
for four weeks he was switched over from Zytiga.
Two weeks ago my dad found out that his PSA jumped from 3.5 to 10 in four weeks on
Xtandi
. He had only been on
Xtandi
for four weeks he was switched over from Zytiga.
Hidden
in
Advanced Prostate Cancer
6 years ago
On Lupron an xgeva , failed zytiga and now on xtandi 3 months psa has doubled every month it is up to 900 , but it’s weird it feel better
Losing hope
Losing hope
Hidden
in
Advanced Prostate Cancer
6 years ago
Apalutamide in the Metastatic Setting
However, my husband was told it would be used next if
Xtandi
isn’t working. He has bone mets.
However, my husband was told it would be used next if
Xtandi
isn’t working. He has bone mets.
Blair77
in
Advanced Prostate Cancer
6 years ago
Second Opinion
Any suggestions on a progressive specialist who can give hope to my 76yr old dad who failed Zytiga in 7 months and
Xtandi
did absolutely nothing for him. His PSA is doubling every 3wks.
Any suggestions on a progressive specialist who can give hope to my 76yr old dad who failed Zytiga in 7 months and
Xtandi
did absolutely nothing for him. His PSA is doubling every 3wks.
Hidden
in
Advanced Prostate Cancer
6 years ago
Xtandi and PSA flare?
Have any of you experienced a PSA flare on
Xtandi
? We got my dad‘s PSA results back and he went from a 3.5 to 10. He was switched from Zytiga to
Xtandi
4 weeks ago. So his PSA jumped from 3.5 to 10 in 4wks during the transition from Zytiga to
Xtandi
!
Have any of you experienced a PSA flare on
Xtandi
? We got my dad‘s PSA results back and he went from a 3.5 to 10. He was switched from Zytiga to
Xtandi
4 weeks ago. So his PSA jumped from 3.5 to 10 in 4wks during the transition from Zytiga to
Xtandi
!
Hidden
in
Advanced Prostate Cancer
6 years ago
Clinical Trial vs. Zytega
The doctor said it only has a 30-35% chance of helping since he became resistant to
Xtandi
. My husband feels like the experimental route is the only way to go at this point, and doesn’t want to lose his spot in the trial.
The doctor said it only has a 30-35% chance of helping since he became resistant to
Xtandi
. My husband feels like the experimental route is the only way to go at this point, and doesn’t want to lose his spot in the trial.
Schess
in
Advanced Prostate Cancer
6 years ago
Xtandi reducing me to sleep walking (aka walking dead)
Starting to think I am going to have to lower my
Xtandi
dosage from 4 pills down to 3. My oncologist doesn't like this idea. PSA has gone slowly down every time it's tested since doing
Xtandi
...finally, just reached 0.96.
Starting to think I am going to have to lower my
Xtandi
dosage from 4 pills down to 3. My oncologist doesn't like this idea. PSA has gone slowly down every time it's tested since doing
Xtandi
...finally, just reached 0.96.
greatjohn
in
Advanced Prostate Cancer
6 years ago
No post for long time, here is my update.
I have been through: Lupron continuous from beginning, Strive, Docetaxal,
Xtandi
, Radium 223, Cabazitaxel, Mitoxantrone and other radiation treatments for pain etc. Throughout the years I’ve been admitted to the hospital for adjustment to my pain meds a few times.
I have been through: Lupron continuous from beginning, Strive, Docetaxal,
Xtandi
, Radium 223, Cabazitaxel, Mitoxantrone and other radiation treatments for pain etc. Throughout the years I’ve been admitted to the hospital for adjustment to my pain meds a few times.
Glsn10
in
Advanced Prostate Cancer
6 years ago
Xtandi [Enzalutamide ]. Continuation of ADT after CRPC & chemo.
New study below [1]. There is sometimes confusion as to the reason for ADT continuation when it has "failed" [CRPC]. Androgen deprivation itself does not fail, but the cancer has found a work-around with the androgen axis generally continuing to be the major player, so it makes sense to continue ADT
New study below [1]. There is sometimes confusion as to the reason for ADT continuation when it has "failed" [CRPC]. Androgen deprivation itself does not fail, but the cancer has found a work-around with the androgen axis generally continuing to be the major player, so it makes sense to continue ADT
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Another fighter
About to begin
xtandi
and xgeva in addition to the eligard. Also poor kidney function due to some damage from the prostate. Have switched pain meds from tramacet to hydromorphone due to interaction with the
xtandi
About to begin
xtandi
and xgeva in addition to the eligard. Also poor kidney function due to some damage from the prostate. Have switched pain meds from tramacet to hydromorphone due to interaction with the
xtandi
2yearsin
in
Advanced Prostate Cancer
6 years ago
Prostate Cancer
His PSA started to increase again June of 2018 and he recently started taking
Xtandi
. My father will not do Chemo (he is 77) which I will respect his decision. He just had another PSA test and after being on the
Xtandi
for a month, the PSA is continuing to increase.
His PSA started to increase again June of 2018 and he recently started taking
Xtandi
. My father will not do Chemo (he is 77) which I will respect his decision. He just had another PSA test and after being on the
Xtandi
for a month, the PSA is continuing to increase.
lifeisabeachMC
in
Advanced Prostate Cancer
6 years ago
PSA rise on Xtandi
4th month of
Xtandi
with declines each month until last week when it jumped from .78 (my nadir) to 1.05. MO says to start contacting our MD Anderson doc for trials. Any thoughts? Already had 10 rounds of taxotere. Wondering how long
Xtandi
lasted for others and when they determined it had failed?
4th month of
Xtandi
with declines each month until last week when it jumped from .78 (my nadir) to 1.05. MO says to start contacting our MD Anderson doc for trials. Any thoughts? Already had 10 rounds of taxotere. Wondering how long
Xtandi
lasted for others and when they determined it had failed?
joekaty
in
Advanced Prostate Cancer
6 years ago
Back from holiday in England, Scotland & Ireland....
~~I am assuming it's from my three months of being on
Xtandi
...as most of the things I read say that Provenge can spike you PSA up. Mine's been steadily going down since starting
Xtandi
. Best wishes to ALL. ~~John p.s. We were gone for 22 days...
~~I am assuming it's from my three months of being on
Xtandi
...as most of the things I read say that Provenge can spike you PSA up. Mine's been steadily going down since starting
Xtandi
. Best wishes to ALL. ~~John p.s. We were gone for 22 days...
greatjohn
in
Advanced Prostate Cancer
6 years ago
TRC253 Trial
RP, Lupron, Zytiga, Doxetel,
Xtandi
, Radium 223. Doctor says I qualify for this trial. Anyone have experience with it? All treatments have failed me, so this is a last ditch effort to stay in the fight. Thanks for your advice.
RP, Lupron, Zytiga, Doxetel,
Xtandi
, Radium 223. Doctor says I qualify for this trial. Anyone have experience with it? All treatments have failed me, so this is a last ditch effort to stay in the fight. Thanks for your advice.
flintknapper
in
Advanced Prostate Cancer
6 years ago
Alkaline Phos and Hemoglobin
He had his 4 week appointment since being switched to
Xtandi
from Zytiga. Zytiga failed after 7 months and now onto
Xtandi
. We still do not have the PSA results however we did get his hemoglobin back and his alkaline Phos.
He had his 4 week appointment since being switched to
Xtandi
from Zytiga. Zytiga failed after 7 months and now onto
Xtandi
. We still do not have the PSA results however we did get his hemoglobin back and his alkaline Phos.
Hidden
in
Advanced Prostate Cancer
6 years ago
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