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Venetoclax
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Venetoclax
First blood test since the ramp up to 400mg Five weeks ago. followed by a phone call 2 days later from the consultant. Good news, bloods going in the right direction.
First blood test since the ramp up to 400mg Five weeks ago. followed by a phone call 2 days later from the consultant. Good news, bloods going in the right direction.
manzelka
in
CLL Support
4 years ago
Venetoclax and low white count
Does the white count and neutrophils stay low throughout the whole time you take
venetoclax
or will they eventually come up like the hemoglobin and platelets?
Does the white count and neutrophils stay low throughout the whole time you take
venetoclax
or will they eventually come up like the hemoglobin and platelets?
Jamstev71
in
CLL Support
4 years ago
B-PLL: Ibrutrinib Monotherapy or Obinutuzumab (aka Gazyva) & Venetoclax Combination as first-line treatment for transformed CLL
We have two CLL experts who propose different treatment plans for first-line therapy: 1) Monotherapy Ibrutinib or Acalabrutinib 2) Combination therapy Gazyva and
Venetoclax
We know that treatment 2 is fixed in duration and holds promise for disease clearance for an indeterminate period of time but
We have two CLL experts who propose different treatment plans for first-line therapy: 1) Monotherapy Ibrutinib or Acalabrutinib 2) Combination therapy Gazyva and
Venetoclax
We know that treatment 2 is fixed in duration and holds promise for disease clearance for an indeterminate period of time but
Phs2385
in
CLL Support
4 years ago
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Stem Cell Transplant
My doctor says that after a 2nd remission, meaning after ibrutinib and
venetoclax
have failed that a stem cell transplant is the next option. I have been on IB for 14 months and it has been amazing but I am terrified about doing a stem cell transplant.
My doctor says that after a 2nd remission, meaning after ibrutinib and
venetoclax
have failed that a stem cell transplant is the next option. I have been on IB for 14 months and it has been amazing but I am terrified about doing a stem cell transplant.
steve_canada
in
CLL Support
4 years ago
Update 3.3 Years Captivate trial, 4.3 years with CLL and so far so good! Now I have to worry about CV-19 ...
The Captivate trial combines Imbruvica with
Venetoclax
. Imbruvica is taken for 3 months then
Venetoclax
is ramped up. ( 20 mg to 50 mg to 100 mg to 200 mg to 400 mg) This protocol worked great for me. I had very bulky nodes and the Imbruvica brought them down in about 1 week. It was amazing.
The Captivate trial combines Imbruvica with
Venetoclax
. Imbruvica is taken for 3 months then
Venetoclax
is ramped up. ( 20 mg to 50 mg to 100 mg to 200 mg to 400 mg) This protocol worked great for me. I had very bulky nodes and the Imbruvica brought them down in about 1 week. It was amazing.
Hoffy
in
CLL Support
4 years ago
Frontline Venetoclax/Obinutuzumab Approved in Europe for CLL
In some welcome good news[i], "The European Commission has approved a fixed-dose combination of
venetoclax
(Venclexta) and obinutuzumab (Gazyva) for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL)"[/i] https://www.onclive.com/web-exclusives/frontline-venetoclaxobinutuzumab-approved-in-europe-in-cll
In some welcome good news[i], "The European Commission has approved a fixed-dose combination of
venetoclax
(Venclexta) and obinutuzumab (Gazyva) for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL)"[/i] https://www.onclive.com/web-exclusives/frontline-venetoclaxobinutuzumab-approved-in-europe-in-cll
AussieNeil
Administrator
in
CLL Support
4 years ago
Leukaemia Care Webinar 8th April - a bit more information
Venetoclax
has the disadvantage of having a bigger negative impact on neutrophils and the need for close monitoring at the start/ramp up phase so unlikely to start on this in the current situation.
Venetoclax
has the disadvantage of having a bigger negative impact on neutrophils and the need for close monitoring at the start/ramp up phase so unlikely to start on this in the current situation.
Jm954
Administrator
in
CLL Support
4 years ago
Anticipating starting venetoclax
Coupled with this is that I’m starting
venetoclax
next Monday - my stomach is flipping a bit - so I spent the weekend sorting out the lower bathroom - sorry if you live in Cheshire and can’t find any paper 😳
Coupled with this is that I’m starting
venetoclax
next Monday - my stomach is flipping a bit - so I spent the weekend sorting out the lower bathroom - sorry if you live in Cheshire and can’t find any paper 😳
Sepsur
in
CLL Support
4 years ago
TO ISOLATE OR NOT?
I was due to start
Venetoclax
therapy tomorrow (Monday) but my consultant phoned on Friday to advise me that in view of the ever increasing cases of coronovirus in the UK, my treatment has been postponed indefinitely for fear of me becoming infected in the hospital environment with a further compromised
I was due to start
Venetoclax
therapy tomorrow (Monday) but my consultant phoned on Friday to advise me that in view of the ever increasing cases of coronovirus in the UK, my treatment has been postponed indefinitely for fear of me becoming infected in the hospital environment with a further compromised
jaypax
in
CLL Support
4 years ago
Taking venetoclax and having a difficult time
They started me on
venetoclax
and ramped it up to 50. My counts got so bad the doctor has temporary taken me off
venetoclax
. How long on
venetoclax
before you get to feeling better. This medicine is something else. I have never been so sick.
They started me on
venetoclax
and ramped it up to 50. My counts got so bad the doctor has temporary taken me off
venetoclax
. How long on
venetoclax
before you get to feeling better. This medicine is something else. I have never been so sick.
Jamstev71
in
CLL Support
4 years ago
Comparative analysis of targeted novel therapies (ibrutinib vs. venetoclax) in relapsed, refractory CLL (Feb 2020)
"In conclusion,
venetoclax
and ibrutinib-based therapy as NA1 provide comparable OS outcomes in R/R CLL patients treated outside of trials.
"In conclusion,
venetoclax
and ibrutinib-based therapy as NA1 provide comparable OS outcomes in R/R CLL patients treated outside of trials.
avzuclav
in
CLL Support
4 years ago
Dr. Mato on Sequencing and what is CLLAN
Mato presents some reassuring data that when we use
venetoclax
, namely that we still have some good options when it stops working in this interview from ASH 2019 (https://cllsociety.org/2020/02/ash-2019-dr-mato-on-sequencing-of-chronic-lymphocytic-leukemia-cll-therapies-after-
venetoclax
/).
Mato presents some reassuring data that when we use
venetoclax
, namely that we still have some good options when it stops working in this interview from ASH 2019 (https://cllsociety.org/2020/02/ash-2019-dr-mato-on-sequencing-of-chronic-lymphocytic-leukemia-cll-therapies-after-
venetoclax
/).
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
Treatment does not have to be something to dread
I got the
venetoclax
arm of the trial but the irritating issues I was dealing with were eliminated before I even started
venetoclax
. My point is, I was dreading and stressed about treatment and was clueless about the positive impact it could have.
I got the
venetoclax
arm of the trial but the irritating issues I was dealing with were eliminated before I even started
venetoclax
. My point is, I was dreading and stressed about treatment and was clueless about the positive impact it could have.
aquafinn
in
CLL Support
4 years ago
An Early Look at When CAR-T Therapy Fails Patients With CLL
Patients whose disease progressed
during
treatment with ibrutinib and treatment with
venetoclax
before CAR-T therapy lived only a median of 7 months after CAR-T therapy.
Patients whose disease progressed
during
treatment with ibrutinib and treatment with
venetoclax
before CAR-T therapy lived only a median of 7 months after CAR-T therapy.
Jm954
Administrator
in
CLL Support
4 years ago
Low LY#?
(PS: before the labs, I ramped-up
Venetoclax
to 50mg today, & got 1000 of Obinutuzumab)
(PS: before the labs, I ramped-up
Venetoclax
to 50mg today, & got 1000 of Obinutuzumab)
DRM18
in
CLL Support
4 years ago
O + V & Antibiotics?
Does anyone here know which—if any—antibiotics someone being treated with Obinutuzumab &
Venetoclax
should avoid? Just curious. Read something about that once, but can’t seem to remember it, nor re-find it. —Dave!
Does anyone here know which—if any—antibiotics someone being treated with Obinutuzumab &
Venetoclax
should avoid? Just curious. Read something about that once, but can’t seem to remember it, nor re-find it. —Dave!
DRM18
in
CLL Support
4 years ago
VENETOCLAX
Btw he had some side effects of Imbruvica so that is why the
VENETOCLAX
Btw he had some side effects of Imbruvica so that is why the
VENETOCLAX
Gogldn
in
CLL Support
4 years ago
Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
Venetoclax
combination treatment reduces immunosuppressive features of CLL, suggesting immune recovery after elimination of tumor cells.
Venetoclax
combination treatment reduces immunosuppressive features of CLL, suggesting immune recovery after elimination of tumor cells.
cllady01
Volunteer
in
CLL Support
4 years ago
What to expect from v + o initial treatment
I am a 77 year old male about to start
venetoclax
+ obinutuzumab. What should I be aware of during the first stages of the treatment? I'm obviously concerned and would like to go in as psychologically prepared as I can be. Thank you in advance for your advice.
I am a 77 year old male about to start
venetoclax
+ obinutuzumab. What should I be aware of during the first stages of the treatment? I'm obviously concerned and would like to go in as psychologically prepared as I can be. Thank you in advance for your advice.
ronsolo306
in
CLL Support
4 years ago
CLL Treatment Advice/Recommendations/Etc For Newbie
After monitoring for 1 year, my doc has recommended that I participate in Trial #EA9161, a 19-month program using ibrutinib, obinutuzumab, &
venetoclax
.
After monitoring for 1 year, my doc has recommended that I participate in Trial #EA9161, a 19-month program using ibrutinib, obinutuzumab, &
venetoclax
.
username-the-dude
in
CLL Support
4 years ago
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