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A question about radiation resistance
Last week a post was made about Decipher showing high radiation resistance. My decipher showed the same. Quick question. If you have had SBRT and it hasn't deliver a “killing dose” to tumor, is brachytherapy a follow up option? My PSA showed rise after SBRT, (from 8.6 to 12) Ro and Mo attributed
Last week a post was made about Decipher showing high radiation resistance. My decipher showed the same. Quick question. If you have had SBRT and it hasn't deliver a “killing dose” to tumor, is brachytherapy a follow up option? My PSA showed rise after SBRT, (from 8.6 to 12) Ro and Mo attributed
Chasbearcat999
in
Prostate Cancer Network
11 days ago
1 year on - no PSA but tumor has "progressed"
Hi all I am writing on behalf of my dad, who is not as tech literate as I am. He was diagnosed with adenocarcinoma of the prostate (suspicious nodule in the left peripheral zone) back in June 2023 following an initial MRI, biopsy and PSA test (results from those tests are below). He was advised to
Hi all I am writing on behalf of my dad, who is not as tech literate as I am. He was diagnosed with adenocarcinoma of the prostate (suspicious nodule in the left peripheral zone) back in June 2023 following an initial MRI, biopsy and PSA test (results from those tests are below). He was advised to
Zudukk
in
Prostate Cancer Network
11 days ago
Pacific Northwest
Hi! We’re beginning to research facilities for second opinions, next step guidance to supplement what we’re learning from our local doctor. My husband is BRCA2 positive, had a prostatectomy, salvage radiation and now his PSA is starting to creep back up. I know it’s too early to take additional treatment
Hi! We’re beginning to research facilities for second opinions, next step guidance to supplement what we’re learning from our local doctor. My husband is BRCA2 positive, had a prostatectomy, salvage radiation and now his PSA is starting to creep back up. I know it’s too early to take additional treatment
Silverlings
in
Advanced Prostate Cancer
11 days ago
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Neuroendocrine Prostate cancer (NEPC) questions.
I’ve had some very concerning symptoms lately so I started looking up more about NEPC. I have some of the listed symptoms. I’ve been under enormous stress lately, caring for my mom who’s in her 90s. The stress may have cause my cancer to mutate. Last year I remember reading something on this site
I’ve had some very concerning symptoms lately so I started looking up more about NEPC. I have some of the listed symptoms. I’ve been under enormous stress lately, caring for my mom who’s in her 90s. The stress may have cause my cancer to mutate. Last year I remember reading something on this site
GeorgeGlass
in
Advanced Prostate Cancer
11 days ago
Making a Case for Intermittent ADT in Metastatic Hormone Sensitive Prostate Cancer
FPC'ers, Many times, we hear people claim that you should only stop ADT if you can't tolerate it any longer, and that it will not slow castrate resistance; that it increases risk for stroke, and heart attack; that it will likely take years for your testosterone to recover; that it increases mortality
FPC'ers, Many times, we hear people claim that you should only stop ADT if you can't tolerate it any longer, and that it will not slow castrate resistance; that it increases risk for stroke, and heart attack; that it will likely take years for your testosterone to recover; that it increases mortality
NPfisherman
in
Fight Prostate Cancer
11 days ago
Any guidance appreciated!
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
LDC2024
in
Advanced Prostate Cancer
12 days ago
Which treatment option best for recurrent oligo?
In addition to SBRT for the two mets that make me join the happy recurrent crowd, what would be my best treatment option? I have had no SOC medication for 2.5 years. My T is 4 European scale 110 US scale. 1 Only ADT for seven months. This is what MO recommends, besides SBRT, since stronger/longer
In addition to SBRT for the two mets that make me join the happy recurrent crowd, what would be my best treatment option? I have had no SOC medication for 2.5 years. My T is 4 European scale 110 US scale. 1 Only ADT for seven months. This is what MO recommends, besides SBRT, since stronger/longer
Purple-Bike
in
Advanced Prostate Cancer
3 months ago
Trying to make sense of things
Can anyone explain why some people have Gleason 8 PC, high PSA and have metastatic disease, yet some with Gleason 9 and 10 have low-ish PSA (as far as PC goes) and no obvious metastatic disease (confirmed by PSMA)? I am trying to understand this damn disease and sometimes there doesn’t seem to be any
Can anyone explain why some people have Gleason 8 PC, high PSA and have metastatic disease, yet some with Gleason 9 and 10 have low-ish PSA (as far as PC goes) and no obvious metastatic disease (confirmed by PSMA)? I am trying to understand this damn disease and sometimes there doesn’t seem to be any
EvFC
in
Advanced Prostate Cancer
13 days ago
Olaparib time to lower PSA
Hello all, Anyone know how long it take for Olaparib ro lower PSA? All I can find is that it takes 90 days to start working. Thanks
Hello all, Anyone know how long it take for Olaparib ro lower PSA? All I can find is that it takes 90 days to start working. Thanks
Seebs9
in
Advanced Prostate Cancer
13 days ago
Ct scan of abdomen and pelvis and full body bone scan?
Hello, I have been advised to get a ct scan of abdomen and pelvis with and without contrast, along with a full body bone scan prior to my next appointment with my urologist. PSA has been undetectable since completion 9/9/20 of image guided radiation to the prostate bed and lymph nodes with a 6 month
Hello, I have been advised to get a ct scan of abdomen and pelvis with and without contrast, along with a full body bone scan prior to my next appointment with my urologist. PSA has been undetectable since completion 9/9/20 of image guided radiation to the prostate bed and lymph nodes with a 6 month
realtorjohn42
in
Advanced Prostate Cancer
13 days ago
Not great news for hubby today. What is next?
Just updated my husband's profile so you can see his journey from 2016. Oncologist today said to continue the Abiraterone for another month and see where we are at with PSA results. Was up again today. He did have 6 rounds of targeted radiation last month, so would that cause PSA to go up. We were hoping
Just updated my husband's profile so you can see his journey from 2016. Oncologist today said to continue the Abiraterone for another month and see where we are at with PSA results. Was up again today. He did have 6 rounds of targeted radiation last month, so would that cause PSA to go up. We were hoping
Docker53
in
Advanced Prostate Cancer
14 days ago
My experience with Docetaxel
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
I know everyone doesn’t respond the same but here is my experience and what I went through with 10 rounds of chemo. Before I started I had already been on Lupron for five years, I had radiation to multiple bone Mets, took zytiga/xtandi, had Provenge and did a clinical trial. October 26 2023 I started
Oct18
in
Advanced Prostate Cancer
16 days ago
What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
16 days ago
Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
The fractionated dosing achieved promising results with 95% of patients experiencing any PSA decline and 71% achieving a PSA50 response. In contrast, the multiple cycles cohort saw 72% of patients with any PSA decline and 28% achieving a PSA50 response...fractionate good! https://www.urotoday.com/conference-highlights
Maxone73
in
Advanced Prostate Cancer
16 days ago
177Lu-PSMA-617: Trial shows it's more effective than changing ARPIs
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
"Patients who enrolled in the trial were assigned to either a change in ARPI, for example from abiraterone to enzalutamide or vice versa, or 177Lu-PSMA-617, a prostate-specific antigen (PSMA)-targeted radioligand therapy. This analysis found that treatment with 177Lu-PSMA-617 prolonged radiographic progression-free
Maxone73
in
Advanced Prostate Cancer
16 days ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
17 days ago
radiation treatment delayed
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
2 years since prostatectomy. Psa still non detectable. Will get it checked again in 6 months or 1 year depending on urologist suggestion. I feel blessed since standard protocol was radiation to the pelvic area had 6 Month Lupron shot since they found positive pc in limp nodes and tissue extracted.
thansen535
in
Advanced Prostate Cancer
17 days ago
Advice - Surgery or Radiation?
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Hi all, apologies for the long post, hoping to give as much info as possible. Background: Diagnosis: Unfavorable int-risk prostate cancer (T2a, Gleason 4+3, PSA 5.2) (I spoke to a surgeon today who said it was T3a so now I am confused) Age: 59 PSA 5.2 (H) 01/31/2024 PSA 4.4 (H) 11/06/2023 PSA
Blue1320
in
Prostate Cancer Network
17 days ago
PSA update
DX Nov 2020. PSA 960 high volume metastatic. Lowest PSA nadir 0.1 Aug 2022. Slowly rising Nov. 2023 was 0.21, Feb 2024 0.41....Doubling time 3.1 months . On Lupron and 1000 mg Abiraterone with 0.5 Dexamethasone . Darn.
DX Nov 2020. PSA 960 high volume metastatic. Lowest PSA nadir 0.1 Aug 2022. Slowly rising Nov. 2023 was 0.21, Feb 2024 0.41....Doubling time 3.1 months . On Lupron and 1000 mg Abiraterone with 0.5 Dexamethasone . Darn.
wolverine11
in
Advanced Prostate Cancer
3 months ago
updated scans post chemo
My dad has done 2 rounds of chemo, the third was delayed by hospitalization for sepsis. He has also had 10 rounds of radiation. His third round will be near Christmas and they completed scans to compare to his pre chemo scans. His full body bone scans state the following “Diffuse skeletal metastatic
My dad has done 2 rounds of chemo, the third was delayed by hospitalization for sepsis. He has also had 10 rounds of radiation. His third round will be near Christmas and they completed scans to compare to his pre chemo scans. His full body bone scans state the following “Diffuse skeletal metastatic
StayingSTRNG
in
Advanced Prostate Cancer
6 months ago
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