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PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
3 months ago
Clinical Trial PT 112 ?
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
I’m writing for my husband who is French (I’m English : we live in France ) He’s 65 and was diagnosed in March 2022 - already metastatic : PSA 36 (previous test 18months before was normal ) Mets in spine and pelvis also liver . Enantone 3 monthly injections and Zytiga to start with. PSA went down
Enilorac63
in
Advanced Prostate Cancer
3 months ago
Is it PSA recurrence or not...
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
My friend had a radical prostatectomy a year ago. Since then his monthly PSA results were stable, at 0.006 3 months ago his PSA went from 0.006 to 0.012, then the next month to 0.029. His MO wanted to see the third month's results in order to consider salvage radiation therapy. Luckily, third month's
traveller64
in
Advanced Prostate Cancer
3 months ago
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Mortality Probability after first PSA rise vs non-castrate testosterone levels (low vs Normal)
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
Here's a plot from Atkins (2018) that shows the Percent risk of Prostate Cancer-specific Mortality versus time following a first PSA failure, for two different non-castrate testosterone levels (Low-T and Normal-T). The low testosterone levels are: median = 162, range = 120-236 ng/dL. Normal T is 400
janebob99
in
Advanced Prostate Cancer
3 months ago
First PSA after RARP
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
My dad had RARP on Jan 19,2024. Gleason 8(4+4) PSA 12, clean PSMA pet scan before surgery. Path report had no LN SVI or EPE but PNI and 50 percent prostate involvement. PSA today 6 weeks post surgery came out to .09. What should we do next? Age 73. Tall_Allen Please advice. Thanks a lot for your help
Pca2024
in
Advanced Prostate Cancer
3 months ago
promising against soft tissue and bone metastasis: AMG 509
there might be hope!! https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147455-esmo-2023-steap1-x-cd3-xmab-2-1-immune-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-interim-results-phase-1-amg-509-xaluritamig.html
there might be hope!! https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147455-esmo-2023-steap1-x-cd3-xmab-2-1-immune-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc-interim-results-phase-1-amg-509-xaluritamig.html
Maxone73
in
Advanced Prostate Cancer
6 months ago
nothing new under the EMBARK sun!
Just a new standard of care emerging https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Just a new standard of care emerging https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Maxone73
in
Advanced Prostate Cancer
6 months ago
177Lu-PNT2002 Significantly Improves rPFS Vs ARPI in Metastatic Castration-Resistant Prostate Cancer
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-castration-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-castration-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
Maxone73
in
Advanced Prostate Cancer
6 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA spiked from .6 to 8.0 in 3 months
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
The blood test corroborates the MRI that shows spread. I am talking with Dr Goodman in the AM. Am I doomed? My PSA has never been 8. before
crony
in
Advanced Prostate Cancer
3 months ago
Pain Management
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Dear All can anyone help. Diagnosed with stage 1V advanced metastatic prostate cancer December 2022. 6 sessions of Chemo, then Firmagon and Nubeqa PSA was 349 now about 1 but has been increasing. Cancer was in most bones but no organs - primarily pelvis and hips - have had radiation treatment but still
Nyon
in
Advanced Prostate Cancer
3 months ago
Finasteride: "Miracle drug" regrows hair, heals prostate, and also boosts heart health ByEric Ralls Earth.com
I am now thinking to add Finasteride to Bicalutamide plus degarelix injections. Would/could it help me if on the psma pet scan my only visible cancer is in my prostate? I had radiation therapy to my prostate but my prostate cancer is back and looks like that the radiation therapy failed and the most
I am now thinking to add Finasteride to Bicalutamide plus degarelix injections. Would/could it help me if on the psma pet scan my only visible cancer is in my prostate? I had radiation therapy to my prostate but my prostate cancer is back and looks like that the radiation therapy failed and the most
Seasid
in
Advanced Prostate Cancer
3 months ago
Ultrahypofractional RT and ADT for Int. Risk PC
I am a 60 year old recently diagnosed PC with a PSA of 11.3 and ultra sound biopsy grade cT1c Gleason 3+4 = 7 Right basal and 3+3 on Right medial only 2 of 12 cores contain cancer. MRI showed PI Rads 5 lesion in right basal peripheral zone and extension into right seminal vesicle. Chose to go with
I am a 60 year old recently diagnosed PC with a PSA of 11.3 and ultra sound biopsy grade cT1c Gleason 3+4 = 7 Right basal and 3+3 on Right medial only 2 of 12 cores contain cancer. MRI showed PI Rads 5 lesion in right basal peripheral zone and extension into right seminal vesicle. Chose to go with
Salmon64
in
Prostate Cancer Network
15 hours ago
QoL be here awhile, ain't going nowhere. PSA/T update
https://youtu.be/TOeefy2v5sc?si=jkRpBWtTS-pszP1n Well, what a long *ss day it was, but I completed the 28 miler up here on my 67th bday, the Big Bear event was postponed to 2025. Did 10, 10, then 8 miles with pit stops at the office for snacks and maybe a beer or two🍺. Raised $2800 for Make a Wish
https://youtu.be/TOeefy2v5sc?si=jkRpBWtTS-pszP1n Well, what a long *ss day it was, but I completed the 28 miler up here on my 67th bday, the Big Bear event was postponed to 2025. Did 10, 10, then 8 miles with pit stops at the office for snacks and maybe a beer or two🍺. Raised $2800 for Make a Wish
dockam
in
Advanced Prostate Cancer
1 day ago
New saliva test for PCa screening
It will be presented this weekend. They claim that it is more specific than PSA screening and also can be done at home using supplied by mailed kits.
It will be presented this weekend. They claim that it is more specific than PSA screening and also can be done at home using supplied by mailed kits.
Justfor_
in
Fight Prostate Cancer
2 days ago
Scary PSA results
I was diagnosed in October 2023 with Gleason 4+5=9. Tissue came from TURP. PSA was 11.8. PSMA Pet was negative for METS. Started ADT on November 9. Did 28 sessions of IMRT from Feb 12, 2024, to Mar 21, 2024. Nadir was .8 on Mar 26 and then the last two have been 1.5 and 3.1. RO said 2.8 was the
I was diagnosed in October 2023 with Gleason 4+5=9. Tissue came from TURP. PSA was 11.8. PSMA Pet was negative for METS. Started ADT on November 9. Did 28 sessions of IMRT from Feb 12, 2024, to Mar 21, 2024. Nadir was .8 on Mar 26 and then the last two have been 1.5 and 3.1. RO said 2.8 was the
7OaksTom
in
Advanced Prostate Cancer
3 days ago
Salvage Brachytherapy
has anyone here had salvage brachytherapy? High dose radiation Brachytherapy is being recommended for me at MSK pending results of a very recent MRI to determine if I can have it. Sounds promising….administered with carefully placed needles over two sessions two weeks apart. Current PSA is 0.02 on
has anyone here had salvage brachytherapy? High dose radiation Brachytherapy is being recommended for me at MSK pending results of a very recent MRI to determine if I can have it. Sounds promising….administered with carefully placed needles over two sessions two weeks apart. Current PSA is 0.02 on
Tommyj2
in
Advanced Prostate Cancer
4 days ago
Pluvicto results (good news), next steps
I completed six Pluvicto treatments at Mayo in Rochester in December 2023. Choline-11 Pet scan in January 2024 showed no evidence of PCa, and PSMA Pet scan on May 22, 2024 continued to show complete remission. Pretty incredible to compare scans from a year ago, riddled with PCa, to the most recent scans
I completed six Pluvicto treatments at Mayo in Rochester in December 2023. Choline-11 Pet scan in January 2024 showed no evidence of PCa, and PSMA Pet scan on May 22, 2024 continued to show complete remission. Pretty incredible to compare scans from a year ago, riddled with PCa, to the most recent scans
Skifanatic
in
Advanced Prostate Cancer
4 days ago
Testosterone is increasing? Should I be worried?
Hello everyone, Since my father’s surgery in 2022, his PSA levels have been undetectable. He receives a Zoladex injection every three months. Until this month, the reference range for total testosterone was 1.93 - 7.40 ug/L, and his result was 0.126 ug/L. This month, the lab's reference value format
Hello everyone, Since my father’s surgery in 2022, his PSA levels have been undetectable. He receives a Zoladex injection every three months. Until this month, the reference range for total testosterone was 1.93 - 7.40 ug/L, and his result was 0.126 ug/L. This month, the lab's reference value format
goodgoal
in
Advanced Prostate Cancer
5 days ago
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