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Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases 2022 (TUDCA)
Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166453/ "Abstract Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated
Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166453/ "Abstract Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded aggregates accumulating. The neurodegenerative process is mediated
Bolt_Upright
in
Cure Parkinson's
2 years ago
ANNOVIS BIO ANNOUNCES POSITIVE FDA NOTICE FOR BUNTANETAP PHASE 3 CLINICAL TRIAL IN PARKINSON'S DISEASE
https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=e4e0b40d-ca20-4758-b8c4-b1289796f7f4 Annovis AnnovisBio gets the nod from US_FDA for their Phase 3 clinical study of Buntanetap (Posiphen) in individuals recently diagnosed with #Parkinsons to proceed; 6 months
https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=e4e0b40d-ca20-4758-b8c4-b1289796f7f4 Annovis AnnovisBio gets the nod from US_FDA for their Phase 3 clinical study of Buntanetap (Posiphen) in individuals recently diagnosed with #Parkinsons to proceed; 6 months
Hidden
in
Cure Parkinson's
2 years ago
Semaglutide as an Answer for ADT Fat Gain & Obesity
The gift of ADT (androgen deprivation) for advanced prostate cancer is a longer life. The harms caused by that same ADT are myriad and have been well discussed here. Included in those range of effects from very low testosterone is a powerful tendency to put on body fat. And to lose muscle mass and strength
The gift of ADT (androgen deprivation) for advanced prostate cancer is a longer life. The harms caused by that same ADT are myriad and have been well discussed here. Included in those range of effects from very low testosterone is a powerful tendency to put on body fat. And to lose muscle mass and strength
MateoBeach
in
Advanced Prostate Cancer
2 years ago
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New medicine for NASH????
Has anyone here heard anything of the trial by Intercept Pharmaceutical? Were you impressed with the results? This is the first paragraph from the article in the Boston Globe: Intercept Pharmaceuticals said Thursday that an extensive re-analysis of a large clinical trial involving its experimental treatment
Has anyone here heard anything of the trial by Intercept Pharmaceutical? Were you impressed with the results? This is the first paragraph from the article in the Boston Globe: Intercept Pharmaceuticals said Thursday that an extensive re-analysis of a large clinical trial involving its experimental treatment
sosteady
in
Living with Fatty Liver and NASH
2 years ago
Prazosin revisited
The sheer beauty of the retrospective study posted recently by Scout4answers is the vast superiority in Recurrence Free Survival for Prazosin users over a ten-year period not only against controls but against a similar drug, Tamsulosin. IMHO this means that selection bias is much less likely. Prazosin
The sheer beauty of the retrospective study posted recently by Scout4answers is the vast superiority in Recurrence Free Survival for Prazosin users over a ten-year period not only against controls but against a similar drug, Tamsulosin. IMHO this means that selection bias is much less likely. Prazosin
Purple-Bike
in
Advanced Prostate Cancer
2 years ago
Join us for a clinical trials webinar on 7/12
The Advantages and Challenges of Clinical Trials Tuesday, July 12 from 12-1 pm ET Let’s reframe the way we think about clinical trials. Did you know that clinical trials are not just for those diagnosed with Stage IV? At any stage of their diagnosis, a patient can look at clinical trials as a potential
The Advantages and Challenges of Clinical Trials Tuesday, July 12 from 12-1 pm ET Let’s reframe the way we think about clinical trials. Did you know that clinical trials are not just for those diagnosed with Stage IV? At any stage of their diagnosis, a patient can look at clinical trials as a potential
SHAREPrograms
Partner
in
SHARE Ovarian Cancer Support
2 years ago
Neck Surgery to support tumour eaten C3 to stabilize neck.
PSA 0.08. But MRI and CT showed C3 being eaten by C3 tumour June 15th 2022. MRI good with no apparent erosion of C3 in Jan 2022. So had emergency neck surgery to support C3. Put rods and screws from skull to C7 to support C3 above and below..Cut out about half of C3 tumour ( peeled some off spinal
PSA 0.08. But MRI and CT showed C3 being eaten by C3 tumour June 15th 2022. MRI good with no apparent erosion of C3 in Jan 2022. So had emergency neck surgery to support C3. Put rods and screws from skull to C7 to support C3 above and below..Cut out about half of C3 tumour ( peeled some off spinal
nobaday
in
Advanced Prostate Cancer
2 years ago
Everything you need to know about clinical trials
Now more than ever, huge importance needs to be placed on the insights gained from clinical trials, and how they can be used to improve overall health outcomes. ------------------------------------------------------------------------- Pre-COVID, HealthUnlocked ran a patient Q&A with The Center for Information
Now more than ever, huge importance needs to be placed on the insights gained from clinical trials, and how they can be used to improve overall health outcomes. ------------------------------------------------------------------------- Pre-COVID, HealthUnlocked ran a patient Q&A with The Center for Information
SaskiaHU
HealthUnlocked
in
HealthUnlocked Blog
2 years ago
Further trials immunotherapy North America
Not sure if anyone's seen this ( it's in North America) but further trials on immunotherapy specific to OC From the CRI website First Patients Dosed in Phase 2 Platform Clinical Trial Testing Novel Immunotherapy Combinations in Highly Malignant Ovarian Cancer Patients with ovarian cancer of the high-grade
Not sure if anyone's seen this ( it's in North America) but further trials on immunotherapy specific to OC From the CRI website First Patients Dosed in Phase 2 Platform Clinical Trial Testing Novel Immunotherapy Combinations in Highly Malignant Ovarian Cancer Patients with ovarian cancer of the high-grade
Cardiff05
in
My Ovacome
2 years ago
Glutathione therapy
Glutathione is an antioxidant that assists in ridding the brain of dangerous free radicals. People with PD have low levels of glutathi-one, specifically in the substantia nigra, the area in the brain where dopamine is lost. This can mean that their cells die faster and the disease progresses more quickly
Glutathione is an antioxidant that assists in ridding the brain of dangerous free radicals. People with PD have low levels of glutathi-one, specifically in the substantia nigra, the area in the brain where dopamine is lost. This can mean that their cells die faster and the disease progresses more quickly
Farooqji
in
Cure Parkinson's
2 years ago
Questions about AEs on Interferons w.r.t. liver enzymes
I have seen erratic liver enzyme levels while attempting to transition from hydroxyurea to Pegasys. I'm not convinced that the Peg is the cause of the issue but my Dr has stopped the Peg and I’m back to 2g of HU with platelets at about 1400 and increasing at a good pace. It is not good. Other than a
I have seen erratic liver enzyme levels while attempting to transition from hydroxyurea to Pegasys. I'm not convinced that the Peg is the cause of the issue but my Dr has stopped the Peg and I’m back to 2g of HU with platelets at about 1400 and increasing at a good pace. It is not good. Other than a
LongETinUS
in
MPN Voice
2 years ago
Probody therapeutics- antibodies that are masked in circulation and cleaved in the tumor to exert a tumor-killing effect locally & selectly
I am posting this not as a stock recommendation but as a question, does anyone know about this technology ? A potentially useful immuno therapy ? June 23, 2022 | 16:02 ET~ CytomX Therapeutics CTMX-NSDQ Rating Outperform Price: Jun-22 $1.80 Target $9.00 Initiating at OP: We Are 'Pro Bodies' on Near-Term
I am posting this not as a stock recommendation but as a question, does anyone know about this technology ? A potentially useful immuno therapy ? June 23, 2022 | 16:02 ET~ CytomX Therapeutics CTMX-NSDQ Rating Outperform Price: Jun-22 $1.80 Target $9.00 Initiating at OP: We Are 'Pro Bodies' on Near-Term
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Here's a $1000 paid online market research study, inviting mCRPC patients, spouses, partners, and caregivers
Here's a $1000 paid online market research study inviting patients, spouses, partners, and caregivers. This study will tap into your/your loved one's personal experience and story as metastatic castration resistant prostate cancer (mCRPC) patients or if you have neuroendocrine prostate cancer. This
Here's a $1000 paid online market research study inviting patients, spouses, partners, and caregivers. This study will tap into your/your loved one's personal experience and story as metastatic castration resistant prostate cancer (mCRPC) patients or if you have neuroendocrine prostate cancer. This
Darryl
Partner
in
Advanced Prostate Cancer
2 years ago
Israeli company to test if fecal bacteria pills boost cancer immunotherapy
Illustration of the human microbiome (Design Cells via iStock by Getty Images)
Israeli company to test if fecal bacteria pills boost cancer immunotherapy
Prospective medication seeks to tweak gut germs in patients who don’t respond well to treatment, utilizing research that suggests microbiome
Illustration of the human microbiome (Design Cells via iStock by Getty Images)
Israeli company to test if fecal bacteria pills boost cancer immunotherapy
Prospective medication seeks to tweak gut germs in patients who don’t respond well to treatment, utilizing research that suggests microbiome
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
Alterity Therapeutics Announces Regulatory Authorization to Proceed with ATH434 Phase 2 Clinical Trial in Italy
https://www.asiaone.com/business/alterity-therapeutics-announces-regulatory-authorization-proceed-ath434-phase-2-clinical-0 Alterity's lead candidate, ATH434, is the first of a new generation of small molecules designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration
https://www.asiaone.com/business/alterity-therapeutics-announces-regulatory-authorization-proceed-ath434-phase-2-clinical-0 Alterity's lead candidate, ATH434, is the first of a new generation of small molecules designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration
Hidden
in
Cure Parkinson's
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
I have referred to the following article a few times in response to some posts about the use and timing of ADT when used in addition (adjuvant) to improve outcomes from salvage radiation therapy for BCR for failure after primary prostate treatment (surgical or radiation or other). Also for recurrences
MateoBeach
in
Fight Prostate Cancer
2 years ago
Clinical trials invitation
Clinical trials invitation :Study title :IMID BIOResource(Immune mediated Inflammatory Diseases) I have been sent this invitation to participate via my Rheumatology Department. It comes from The National Institute for Health Research. Only too pleased to help after 50 years of RA. Lots of progress made
Clinical trials invitation :Study title :IMID BIOResource(Immune mediated Inflammatory Diseases) I have been sent this invitation to participate via my Rheumatology Department. It comes from The National Institute for Health Research. Only too pleased to help after 50 years of RA. Lots of progress made
tinlizzie
in
NRAS
2 years ago
Phase 3, the Lighthouse study, Biogen and Denali, LRRK2 inhibitor BIIB122; New clinical trial registered
New clinical trial registered: Biogen and Denaliti have initiated the 2nd late-stage study of their LRRK2 inhibitor BIIB122; Phase 3, randomized, double-blind, placebo-controlled efficacy & safety study in 400 individuals with LRRK2-associated #Parkinsons https://clinicaltrials.gov/ct2/show/NCT05418673
New clinical trial registered: Biogen and Denaliti have initiated the 2nd late-stage study of their LRRK2 inhibitor BIIB122; Phase 3, randomized, double-blind, placebo-controlled efficacy & safety study in 400 individuals with LRRK2-associated #Parkinsons https://clinicaltrials.gov/ct2/show/NCT05418673
Hidden
in
Cure Parkinson's
2 years ago
New clinical trial registered: Inhibikase Therapeutics are initiating a Phase 2 study of their c-ABL inhibitor IkT-148009
New clinical trial registered: Inhibikase Therapeutics @inhibikase are initiating a Phase 2 study of their c-ABL inhibitor IkT-148009 in 120 individuals with untreated #Parkinsons; Safety & tolerability of 3 doses; 12-week study https://clinicaltrials.gov/ct2/show/NCT05424276 https://twitter.com/ScienceofPD
New clinical trial registered: Inhibikase Therapeutics @inhibikase are initiating a Phase 2 study of their c-ABL inhibitor IkT-148009 in 120 individuals with untreated #Parkinsons; Safety & tolerability of 3 doses; 12-week study https://clinicaltrials.gov/ct2/show/NCT05424276 https://twitter.com/ScienceofPD
Hidden
in
Cure Parkinson's
2 years ago
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