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Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
9 hours ago
Megaloblastic anaemia
Hi, I was diagnosed with megaloblastic anaemia yesterday. My gp, sent over a prescription for Cyanocobalamin 1mg/1ml solution for injection ampoules. My pharmacy and other pharmacies don't stock it. I left a note for my doctor with the receptionist to ask for possibly a different brand or type. I'm new
Hi, I was diagnosed with megaloblastic anaemia yesterday. My gp, sent over a prescription for Cyanocobalamin 1mg/1ml solution for injection ampoules. My pharmacy and other pharmacies don't stock it. I left a note for my doctor with the receptionist to ask for possibly a different brand or type. I'm new
fatfatfat
in
Pernicious Anaemia Society
7 days ago
promising delivery technique for cancer drugs
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
Maxone73
in
Advanced Prostate Cancer
7 days ago
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Berberine and iron?
Hi, So glad to have found this wonderful forum! I am a 74 year female who recently started taking pregabalin for RLS. I just got back my ferritin level and it is 12. I will order some iron and would like to know how many mg is a good dose. Also, I started taking niacin 500mg daily for my cholesterol
Hi, So glad to have found this wonderful forum! I am a 74 year female who recently started taking pregabalin for RLS. I just got back my ferritin level and it is 12. I will order some iron and would like to know how many mg is a good dose. Also, I started taking niacin 500mg daily for my cholesterol
glorious-granny
in
Restless Legs Syndrome
8 days ago
Wednesday's 'Word'
[u][i]
Hepatocytes -
[/i][/u] These are simply the cells of the liver. Each of these cells performs all of the functions of the liver - there is no difference in what any of them do for us. Liver failure occurs when there are not enough functioning hepatocytes to do all the functions they are
[u][i]
Hepatocytes -
[/i][/u] These are simply the cells of the liver. Each of these cells performs all of the functions of the liver - there is no difference in what any of them do for us. Liver failure occurs when there are not enough functioning hepatocytes to do all the functions they are
DonnaBoll
Administrator
in
PBC Foundation
9 days ago
Indapamide
I have been on 10mg Amlodipine and 10mg Ramipril for some years now. My blood pressure has slight increased to 135/96. Due to the raised DBP, my doctors wants me to add Indapamide. Is anybody taking Indapamide? are there any side affects? Would be interested in hearging from anyone who is
I have been on 10mg Amlodipine and 10mg Ramipril for some years now. My blood pressure has slight increased to 135/96. Due to the raised DBP, my doctors wants me to add Indapamide. Is anybody taking Indapamide? are there any side affects? Would be interested in hearging from anyone who is
AnimalNatureLover
in
High Blood Pressure Support
11 days ago
Starting fresh - probiotics
Hello people. I recently became disillusioned with the supplements I was taking. It came about because I restarted berberine after a three month break. My normal brand, renew by science, have doubled their strength, and within a day or two I was finding I was ridiculously tired, like I'd run a marathon
Hello people. I recently became disillusioned with the supplements I was taking. It came about because I restarted berberine after a three month break. My normal brand, renew by science, have doubled their strength, and within a day or two I was finding I was ridiculously tired, like I'd run a marathon
Karmaone
in
Cure Parkinson's
12 days ago
Low Sodium Level
Hello Seeing low sodium levels in blood work, and they believe it is because of the cancer cells. I do take salt tablets and increase salt in food and drink. What's the best way to prove methods of increasing sodium levels?
Hello Seeing low sodium levels in blood work, and they believe it is because of the cancer cells. I do take salt tablets and increase salt in food and drink. What's the best way to prove methods of increasing sodium levels?
God_Loves_Me
in
Advanced Prostate Cancer
16 days ago
Rapid Onset of Symptoms
Hello, I was wondering if anyone can help me…. My dad has been diagnosed with PSP only a few months ago but has had symptoms for about 18months. His recent symptoms were textbook stage 2 but quite independent ….. this past Sunday morning he woke up feeling a bit off and then suddenly lost feeling in
Hello, I was wondering if anyone can help me…. My dad has been diagnosed with PSP only a few months ago but has had symptoms for about 18months. His recent symptoms were textbook stage 2 but quite independent ….. this past Sunday morning he woke up feeling a bit off and then suddenly lost feeling in
IPinkie
in
PSP Association
16 days ago
does anyone use pepto-bismol?
interesting article in the New York Times today about a man with Parkinson’s who suddenly deteriorated and it was eventually found to be caused by the Bismuth containing meds he was taking. https://www.nytimes.com/2024/03/07/magazine/bismuth-toxicity-pepto-bismol.html ”DiCenso was also struck by the
interesting article in the New York Times today about a man with Parkinson’s who suddenly deteriorated and it was eventually found to be caused by the Bismuth containing meds he was taking. https://www.nytimes.com/2024/03/07/magazine/bismuth-toxicity-pepto-bismol.html ”DiCenso was also struck by the
LAJ12345
in
Cure Parkinson's
16 days ago
Statins
I have AF but it’s controlled so far with daily flecainide and bisoprolol. I get a three monthly blood test for iron overload but this week the doctor advised me to get a cholesterol blood test as well. All of my results for cholesterol were within the ranges but my doc advised that it’s recommended
I have AF but it’s controlled so far with daily flecainide and bisoprolol. I get a three monthly blood test for iron overload but this week the doctor advised me to get a cholesterol blood test as well. All of my results for cholesterol were within the ranges but my doc advised that it’s recommended
Profound15
in
Atrial Fibrillation Support
21 days ago
Heart Palps after eating
Does anyone get Heart palpitations after eating ? I get them no matter what I eat protein only, prot & carbs or carbs (tested this) … This isn’t new but its becoming more pronounced and I can’t figure out the issues or if it’s hypo related but just seems odd to hit only after eating (morning) is the
Does anyone get Heart palpitations after eating ? I get them no matter what I eat protein only, prot & carbs or carbs (tested this) … This isn’t new but its becoming more pronounced and I can’t figure out the issues or if it’s hypo related but just seems odd to hit only after eating (morning) is the
Batty1
in
Thyroid UK
23 days ago
Ranolazine (used for angina) could potentially be repurposed for PCa. Only mouse studies so far.
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
Graham49
in
Advanced Prostate Cancer
25 days ago
accidental overdose,
has anyone taken too many sotalol, I felt unwell with extreme heat ,legs like jelly and breathless, Later realised I had taken 4x80 mg of sotalol instead of 2. Can anyone advise wether these are the symptoms of taking too much or could have been something else entirely. Looking forward to some helpful
has anyone taken too many sotalol, I felt unwell with extreme heat ,legs like jelly and breathless, Later realised I had taken 4x80 mg of sotalol instead of 2. Can anyone advise wether these are the symptoms of taking too much or could have been something else entirely. Looking forward to some helpful
Hatten28
in
Atrial Fibrillation Support
1 month ago
Thyroid Antibodies
Just read a post from Thyroid UK about antibodies. The raised TPO connection seems clear, but then It says “The next group is the TG Ab. These levels rise as well as the TPO Ab levels in autoimmune thyroiditis, but to a lesser degree...” I don’t understand what this is saying…does it mean that BOTH
Just read a post from Thyroid UK about antibodies. The raised TPO connection seems clear, but then It says “The next group is the TG Ab. These levels rise as well as the TPO Ab levels in autoimmune thyroiditis, but to a lesser degree...” I don’t understand what this is saying…does it mean that BOTH
JoJoloveschocolate
in
Thyroid UK
1 month ago
Anyone experienced HbA1c increasing after starting T3, and increasing more when Levo reduced, does it settle , is it temporary
hoping to find out, if it will eventually right itself when thyroid issues are treated optimally. I think/hope it might but would be good if others have any experience references that could back up my intuition. I was px venlafaxine early 2019, had never had any blood glucose issues before that. Lipids
hoping to find out, if it will eventually right itself when thyroid issues are treated optimally. I think/hope it might but would be good if others have any experience references that could back up my intuition. I was px venlafaxine early 2019, had never had any blood glucose issues before that. Lipids
Polo22
in
Thyroid UK
1 month ago
Cholesterol question
I happened to be at a cardiologist appt the other day. I read an article there about cholesterol. Hope you can access an article in the Journal of the American College of Cardiology- November issue by Dr. Leslie Cho. I did ask the NP about a largely elevated HDL ( good cholesterol). She had bever heard
I happened to be at a cardiologist appt the other day. I read an article there about cholesterol. Hope you can access an article in the Journal of the American College of Cardiology- November issue by Dr. Leslie Cho. I did ask the NP about a largely elevated HDL ( good cholesterol). She had bever heard
DonnaBoll
Administrator
in
PBC Foundation
1 month ago
Tybon Henning Liothyronine
I have been taking this particular liothyronine for many years alongside my levothyroxine and now have been told by the pharmacy that it is no longer available. Could anyone on here please confirm this is the correct information I have been given? I had this particular brand as it was lactose free and
I have been taking this particular liothyronine for many years alongside my levothyroxine and now have been told by the pharmacy that it is no longer available. Could anyone on here please confirm this is the correct information I have been given? I had this particular brand as it was lactose free and
fifi6
in
Thyroid UK
1 month ago
Oncolytic Virotherapy Platform Designed to Target All Tumor Sites: we will have some news soon, oncolytics are very promising (CLD-201)
– Preclinical models have demonstrated the ability to resist oncolytic virus inactivation by human serum and target diverse tumor types – Novel therapeutic approach allows for ease of administration, increased cost-effectiveness, and the ability to reach a broad patient population Enough for me to
– Preclinical models have demonstrated the ability to resist oncolytic virus inactivation by human serum and target diverse tumor types – Novel therapeutic approach allows for ease of administration, increased cost-effectiveness, and the ability to reach a broad patient population Enough for me to
Maxone73
in
Advanced Prostate Cancer
1 month ago
ACR (Microalbumin/Creatinine Ratio)
My Urine’s ACR result is 8.4 mg/mmol. HbA1C is 8.5. I am very worried. Kindly advise or provide insights.
My Urine’s ACR result is 8.4 mg/mmol. HbA1C is 8.5. I am very worried. Kindly advise or provide insights.
Limeandlemon
in
Diabetes India
2 months ago
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