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Apalutamide (Erleada) Only Lasted 6-7 Months! What Next?
After being on Apalutamide, Lupron, & Xgeva, since April of 2022, & PSA drop from 7.3 (extensive bone mets.) & a drop to 0.1 (for 2 mons.), PSA rose to 0.6 over 3 mon. w/o lab work because doing so well. So, don't know exactly when it started to rise but the rate of increase is geometric! MO wanted
After being on Apalutamide, Lupron, & Xgeva, since April of 2022, & PSA drop from 7.3 (extensive bone mets.) & a drop to 0.1 (for 2 mons.), PSA rose to 0.6 over 3 mon. w/o lab work because doing so well. So, don't know exactly when it started to rise but the rate of increase is geometric! MO wanted
john4803
in
Advanced Prostate Cancer
1 year ago
Looking for suggestion of clinical trials for mCRPC
I have had SBRT (2007), Chemotherapy (2010/2011), ADT using Casodex/Lupron/Zytiga (2012-Current). Interested in joining trials that involve PARP inihibitors, immunotherapy, or other new/novel therapies. Can any of you suggest trials currently accepting candidates. My PSA was undetectable (<0.01) for
I have had SBRT (2007), Chemotherapy (2010/2011), ADT using Casodex/Lupron/Zytiga (2012-Current). Interested in joining trials that involve PARP inihibitors, immunotherapy, or other new/novel therapies. Can any of you suggest trials currently accepting candidates. My PSA was undetectable (<0.01) for
Cmdrdata
in
Advanced Prostate Cancer
1 year ago
Heavy breathing .
Does anybody else run out of breath easily? I find myself panting with minimal exertion. Is it disease or steroids? Am on 20 mgs medrol. Thx.
Does anybody else run out of breath easily? I find myself panting with minimal exertion. Is it disease or steroids? Am on 20 mgs medrol. Thx.
Merryfield
in
PMRGCAuk
1 year ago
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Hot flashes and Lupron
Hi All - I'm looking for advice in a rather special case - I've been on Lupron for a bit over a year, and on Ariraterone for about 8 months. Last month, my MO pulled me from Abiraterone because my blood pressure was out of control, and tripling the ARB that I am taking really did not seem like a great
Hi All - I'm looking for advice in a rather special case - I've been on Lupron for a bit over a year, and on Ariraterone for about 8 months. Last month, my MO pulled me from Abiraterone because my blood pressure was out of control, and tripling the ARB that I am taking really did not seem like a great
chickgreen
in
Advanced Prostate Cancer
1 year ago
should I be worried?
looking for some insite as to what I should expect going forward given the state of my condition. Had prostatectomy in 2019. Gleason 4+3. PSA before operation was 3.4. Remained undetectable for 4 months, then rise to 1.9 over 4 months. PSMA scan detected one lymph node in pelvis. Went for 40 rounds
looking for some insite as to what I should expect going forward given the state of my condition. Had prostatectomy in 2019. Gleason 4+3. PSA before operation was 3.4. Remained undetectable for 4 months, then rise to 1.9 over 4 months. PSMA scan detected one lymph node in pelvis. Went for 40 rounds
Jroc1
in
Advanced Prostate Cancer
1 year ago
Docetaxel or not?
After 4 years of Active Surveillance my Gleason went to 7. I had a 6 month Lupron shot and Proton radiation 7 years ago. 39 treatments. After 6 years of nothing my PSA started to climb up to 1.98. Did an Axumin scan and found two mets in my lower left pelvic Lymph Node. Took a Lupron shot and got
After 4 years of Active Surveillance my Gleason went to 7. I had a 6 month Lupron shot and Proton radiation 7 years ago. 39 treatments. After 6 years of nothing my PSA started to climb up to 1.98. Did an Axumin scan and found two mets in my lower left pelvic Lymph Node. Took a Lupron shot and got
icanwintwice
in
Advanced Prostate Cancer
1 year ago
Anyone have mBAT experience?
I'm mCRPC with node involvement, extensive bone mets, and recent liver mets. I was diagnosed with mHSPC (bone and node) in June 2021, I progressed on Lupron/Zytiga with 6 cycles of docetaxel (PEACE1 triple therapy protocol) in October 2022. I dId Provenge at time of progression and am currently on
I'm mCRPC with node involvement, extensive bone mets, and recent liver mets. I was diagnosed with mHSPC (bone and node) in June 2021, I progressed on Lupron/Zytiga with 6 cycles of docetaxel (PEACE1 triple therapy protocol) in October 2022. I dId Provenge at time of progression and am currently on
Djangler
in
Advanced Prostate Cancer
1 year ago
Information please on next treatment options
My husband was diagnosed in Jan 2020 with stage 4 prostate cancer with bone metastasis. He is castrate-resistant. He is on Lupron every three months. Zytiga failed after about a year. He is now on his fourth chemo (cab) which the doctor thinks is not working. He mentioned four options that he thinks
My husband was diagnosed in Jan 2020 with stage 4 prostate cancer with bone metastasis. He is castrate-resistant. He is on Lupron every three months. Zytiga failed after about a year. He is now on his fourth chemo (cab) which the doctor thinks is not working. He mentioned four options that he thinks
margretrburns
in
Advanced Prostate Cancer
1 year ago
Need to restage cancer
Due to being castration resistant and PSA rising while on Xtandi/Lupron, his MO says she needs scan(s) to restage his cancer. The problem is that my husband can't tolerate lying on his back for the duration and/or keep his arms raised above his head. He tried to have a PET scan last year but had to cut
Due to being castration resistant and PSA rising while on Xtandi/Lupron, his MO says she needs scan(s) to restage his cancer. The problem is that my husband can't tolerate lying on his back for the duration and/or keep his arms raised above his head. He tried to have a PET scan last year but had to cut
Shamrock46
in
Advanced Prostate Cancer
1 year ago
How long after chemotherapy you return to your "normal" pre chemotherapy?
Between March and July 2022 I had six rounds of Docetaxel + Carboplatin and I dont seem to recover ,mainly fatigue. Can not bring myself to some decent level of energy. my pre treatment Karnofsky index was 90-100 , now it is 70-80 😕 I'm also doing Lupron shots and Nubeqa which of course contribute
Between March and July 2022 I had six rounds of Docetaxel + Carboplatin and I dont seem to recover ,mainly fatigue. Can not bring myself to some decent level of energy. my pre treatment Karnofsky index was 90-100 , now it is 70-80 😕 I'm also doing Lupron shots and Nubeqa which of course contribute
dorke
in
Advanced Prostate Cancer
1 year ago
Information please on next treatment options
My husband was diagnosed in Jan 2020 with stage 4 prostate cancer with bone metastasis. He is castrate-resistant. He is on Lupron every three months. Zytiga failed after about a year. He is now on his fourth chemo (cab) which the doctor thinks is not working. He mentioned four options that he thinks
My husband was diagnosed in Jan 2020 with stage 4 prostate cancer with bone metastasis. He is castrate-resistant. He is on Lupron every three months. Zytiga failed after about a year. He is now on his fourth chemo (cab) which the doctor thinks is not working. He mentioned four options that he thinks
margretrburns
in
Fight Prostate Cancer
1 year ago
Triplet therapy - stage 4 diagnosis
Is it best to start triplet therapy first before trying other treatments for stage 4 ? My uncle is stage 4 with spread to nearby lymph nodes and seminal vescile invasion, but no bone spread. They are starting him on Casodex and lupron shots. Can he actually do tripley therapy right away or have
Is it best to start triplet therapy first before trying other treatments for stage 4 ? My uncle is stage 4 with spread to nearby lymph nodes and seminal vescile invasion, but no bone spread. They are starting him on Casodex and lupron shots. Can he actually do tripley therapy right away or have
sportsguyredsox
in
Advanced Prostate Cancer
1 year ago
First ever PSMA scan shows two small bone lesions
I recently posted about my father who had just completed IMRT and three years of Lupron (no mets seen on bone/CT scans). At the time his MO was suggesting adding Zytiga per studies showing its effectiveness with ADT at diagnosis for localized high grade cancer (he is Gleason 9). MO also ordered PSMA
I recently posted about my father who had just completed IMRT and three years of Lupron (no mets seen on bone/CT scans). At the time his MO was suggesting adding Zytiga per studies showing its effectiveness with ADT at diagnosis for localized high grade cancer (he is Gleason 9). MO also ordered PSMA
mooman80
in
Advanced Prostate Cancer
1 year ago
Vacation time?
I'm starting year 5. I started in 2018 with PC a surprise finding during an MRI for chronic but low grade low back pain. For past 4 years I've had stable PSA varying from 7 to 11 and back. Treatment is Lupron and Zytiga +Prednisone all at standard quantities. MO considers this level as probably
I'm starting year 5. I started in 2018 with PC a surprise finding during an MRI for chronic but low grade low back pain. For past 4 years I've had stable PSA varying from 7 to 11 and back. Treatment is Lupron and Zytiga +Prednisone all at standard quantities. MO considers this level as probably
pdold
in
Advanced Prostate Cancer
1 year ago
brain fog
I started Lupron and Zytiga about 5 months ago. Along with all of the other side effects, I have had a noticeable mental fog the has descended. Anyone else?
I started Lupron and Zytiga about 5 months ago. Along with all of the other side effects, I have had a noticeable mental fog the has descended. Anyone else?
OldGuysRule
in
Advanced Prostate Cancer
1 year ago
Starting relugolix / OrgovyxÂ
My healthcare provider indicated they wouldn't prescribe Orgovyx and to use Lupron instead. Has anyone dealt with this? Are there ways to get the meds cheaper from Canada or elsewhere? Any insight would be great. My rationale is that Orgovyx may have fewer side effects, and concerned as I still go
My healthcare provider indicated they wouldn't prescribe Orgovyx and to use Lupron instead. Has anyone dealt with this? Are there ways to get the meds cheaper from Canada or elsewhere? Any insight would be great. My rationale is that Orgovyx may have fewer side effects, and concerned as I still go
plato123
in
Advanced Prostate Cancer
1 year ago
prostrate cancer
lupron. seems this drug kills testosterone and is supposed to starve cancer cells.. while radiation kills the cancer.. I was reading. Outsmart your cancer by Tanya Pierce.. The medical argument is that testosterone is the evil thing here but really is a lame argument.. As Dr White has said if this
lupron. seems this drug kills testosterone and is supposed to starve cancer cells.. while radiation kills the cancer.. I was reading. Outsmart your cancer by Tanya Pierce.. The medical argument is that testosterone is the evil thing here but really is a lame argument.. As Dr White has said if this
Terribleten
in
Men's Health Forum
1 year ago
How content should I be with my current treatment 🤷
Yay, I finally expanded my treatment history into a useful document! Just did the update. The dust seems to have settled into my current treatment of Lupron, Abiraterone, and Prednisone. And I have to admit I'm enjoying riding that path quietly for a while. On the other hand I'm still confused about
Yay, I finally expanded my treatment history into a useful document! Just did the update. The dust seems to have settled into my current treatment of Lupron, Abiraterone, and Prednisone. And I have to admit I'm enjoying riding that path quietly for a while. On the other hand I'm still confused about
Lewellen
in
Advanced Prostate Cancer
1 year ago
When ADT fails, we continue it anyway... why not Zytiga?
This question may be more theoretical than practical, but I am curious. We use ADT to lower T and get a PSA response and regression of PC (and get symptom relief). Eventually ADT "fails" and PSA rises. But ADT continues to "succeed" in keeping T low, so we stay on it, since low T continues to be important
This question may be more theoretical than practical, but I am curious. We use ADT to lower T and get a PSA response and regression of PC (and get symptom relief). Eventually ADT "fails" and PSA rises. But ADT continues to "succeed" in keeping T low, so we stay on it, since low T continues to be important
noahware
in
Advanced Prostate Cancer
1 year ago
What do these results mean
Hi, I need your help to understand the following results. I was diagnosed with stage 4 metastatic (throughout my body) PC last Feb with a PSA of 935. I was put on the triple therapy with Lupron, Zytiga and 6 rounds of taxotere. Today my PSA is 0.03 and I just received the following results from
Hi, I need your help to understand the following results. I was diagnosed with stage 4 metastatic (throughout my body) PC last Feb with a PSA of 935. I was put on the triple therapy with Lupron, Zytiga and 6 rounds of taxotere. Today my PSA is 0.03 and I just received the following results from
Lslal
in
Advanced Prostate Cancer
1 year ago
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