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Experiences with
Luteinizing hormone releasing hormone (LHRH) agonist
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ADT and bone loss lost opportunity !?
I got, with great difficulty a DEXA scan one month after starting
LHRH
agonist
goserelin. No one told me I needed it, and given my polio as a kid I probably was likely to already have some osteoporosis risk at 73. And yes I had lumber osteoporosis and osteopenia in my hip and neck of femur.
I got, with great difficulty a DEXA scan one month after starting
LHRH
agonist
goserelin. No one told me I needed it, and given my polio as a kid I probably was likely to already have some osteoporosis risk at 73. And yes I had lumber osteoporosis and osteopenia in my hip and neck of femur.
SimMartin
in
Advanced Prostate Cancer
21 days ago
ADT 's effect on body fat and muscle mass from Life on ADT blog by Richard Wassersug
ADT’s impact on Muscle and Fat October 23, 2023 Standard ADT with either
LHRH
agonist
or antagonist drugs (like Lupron or Firmagon, respectively) cause a loss of lean muscle mass and weight gained as fat. Those are among the most common side effects of ADT.
ADT’s impact on Muscle and Fat October 23, 2023 Standard ADT with either
LHRH
agonist
or antagonist drugs (like Lupron or Firmagon, respectively) cause a loss of lean muscle mass and weight gained as fat. Those are among the most common side effects of ADT.
Scout4answers
in
Advanced Prostate Cancer
7 months ago
CVD & GnRH agonists/antagonists
New study below [1]. Men with PCa have a greater risk of death from cardiovascular [CV] events, and androgen deprivation therapy [ADT] further increases that risk. The study looked at ADT drugs that target gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. The drugs were Degarelix
New study below [1]. Men with PCa have a greater risk of death from cardiovascular [CV] events, and androgen deprivation therapy [ADT] further increases that risk. The study looked at ADT drugs that target gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. The drugs were Degarelix
pca2004
in
Fight Prostate Cancer
1 year ago
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Switching from Firmagon to Lucrin or Eligard
agonist
.
agonist
.
huraymond
in
Advanced Prostate Cancer
2 years ago
Recommendations for a good dietician / nutritionist (UK)
Hello :) For anyone based in the UK (London if it's face to face), do you have a great dietician / nutritionist that you can recommend? I have endometriosis and IBS. I'd also like to lose some weight and generally have a better lifestyle / relationship with food / improve my energy levels. I've just
Hello :) For anyone based in the UK (London if it's face to face), do you have a great dietician / nutritionist that you can recommend? I have endometriosis and IBS. I'd also like to lose some weight and generally have a better lifestyle / relationship with food / improve my energy levels. I've just
BlueMorpho13
in
Endometriosis UK
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Starting
LHRH
agonist
on the first day of radiation therapy, as in the EORTC 22863 study, should be the standard of care when treating locally advanced prostate cancer.
Starting
LHRH
agonist
on the first day of radiation therapy, as in the EORTC 22863 study, should be the standard of care when treating locally advanced prostate cancer.
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Starting
LHRH
agonist
on the first day of radiation therapy, as in the EORTC 22863 study, should be the standard of care when treating locally advanced prostate cancer.
Starting
LHRH
agonist
on the first day of radiation therapy, as in the EORTC 22863 study, should be the standard of care when treating locally advanced prostate cancer.
MateoBeach
in
Fight Prostate Cancer
2 years ago
End of Treatment Options? Oncologist says Make Yourself Comfortable Suggestions
Satterfield's office regarding his
LHRH
agonist
. Is this all or where to from here??????????
Satterfield's office regarding his
LHRH
agonist
. Is this all or where to from here??????????
Willy9173
in
Advanced Prostate Cancer
2 years ago
Molecular Characteristics of Patients With mCRPC Achieving Deep Responses to BAT
All patients were treated using 400 mg testosterone cypionate intramuscularly every 28 days, together with continuous
LHRH
agonist
therapy. Clinical-grade DNA sequencing was obtained using commercially available assays.
All patients were treated using 400 mg testosterone cypionate intramuscularly every 28 days, together with continuous
LHRH
agonist
therapy. Clinical-grade DNA sequencing was obtained using commercially available assays.
podsart
in
Advanced Prostate Cancer
2 years ago
Extracts from two papers on exercise and cancer. Paper 1 investigates the blood from 25 patients with mCRPC exercising. Paper 2 is a review.
Briefly, patients who had been identified as mCRPC (adenocarcinoma of the prostate with systemic metastatic disease despite castrate levels of testosterone (<50 ng/dl) due to orchiectomy or luteinising hormone-releasing hormone (
LHRH
)
agonist
, undergoing ADT (gonadotropin-releasing hormone (GnRH) agonist
Briefly, patients who had been identified as mCRPC (adenocarcinoma of the prostate with systemic metastatic disease despite castrate levels of testosterone (<50 ng/dl) due to orchiectomy or luteinising hormone-releasing hormone (
LHRH
)
agonist
, undergoing ADT (gonadotropin-releasing hormone (GnRH) agonist
Graham49
in
Advanced Prostate Cancer
2 years ago
The overall risk for major adverse cardiovascular events (MACE) in men with prostate cancer may be lower than previously assumed
The new study analyzed the US electronic medical records of 45,059 men with prostate cancer receiving a luteinizing hormone releasing hormone (
LHRH
)
agonist
and antagonist injections. The team examined the rate of MACE within 6 months and 1 year of ADT initiation.
The new study analyzed the US electronic medical records of 45,059 men with prostate cancer receiving a luteinizing hormone releasing hormone (
LHRH
)
agonist
and antagonist injections. The team examined the rate of MACE within 6 months and 1 year of ADT initiation.
Graham49
in
Advanced Prostate Cancer
2 years ago
COMBAT-CRPC: COncurrent adMinistration of Bipolar Androgen Therapy and Nivolumab in men with mCRPC
This was a multi-center, single-arm, open-label phase 2 trial of men with mCRPC who received testosterone cypionate 400mg intramuscular (BAT) every 28 days and nivolumab 480mg IV every 28 days, during which time
LHRH
agonist
treatment was continued.
This was a multi-center, single-arm, open-label phase 2 trial of men with mCRPC who received testosterone cypionate 400mg intramuscular (BAT) every 28 days and nivolumab 480mg IV every 28 days, during which time
LHRH
agonist
treatment was continued.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Diphereline (Triptorelinum, Decapeptyl, Gonapeptyl, Triptodur...)= GnRH agonist injections?
One week ago I recieved Diphereline 3,75 mg first injection. And one month ago i had lap enfometriosi excision operation. So far I feel actualy grate.. I never could imagine.. that I would feel like yung person again.. (Im still 32).. full with energy. Im worried abaut Diphereline! I heard that it
One week ago I recieved Diphereline 3,75 mg first injection. And one month ago i had lap enfometriosi excision operation. So far I feel actualy grate.. I never could imagine.. that I would feel like yung person again.. (Im still 32).. full with energy. Im worried abaut Diphereline! I heard that it
Mince_LV
in
Endometriosis UK
3 years ago
21Aug21 ART Androgen deprivation therapy (ADT) during and after post-prostatectomy radiotherapy in patients with prostate cancer
The GETUG-AFU 16 trial demonstrated that 6 months of luteinizing hormone releasing hormone (
LHRH
)
agonist
treatment during salvage RT significantly reduced clinical progression (5-year progression-free survival, 80.0 vs. 62.0%). c.
The GETUG-AFU 16 trial demonstrated that 6 months of luteinizing hormone releasing hormone (
LHRH
)
agonist
treatment during salvage RT significantly reduced clinical progression (5-year progression-free survival, 80.0 vs. 62.0%). c.
RMontana
in
Active Surveillance - Prostate Cancer
3 years ago
Extreme side-effects from ADT
In the recent Lancet article about the PATCH trial, men on
LHRH
agonist
for 6 months had a mean increase of 0.14 mmol/l, with a range of 0.04 - 0.24. My increase is 2.5 units i.e. tenfold that of the person with the largest increase in the group.
In the recent Lancet article about the PATCH trial, men on
LHRH
agonist
for 6 months had a mean increase of 0.14 mmol/l, with a range of 0.04 - 0.24. My increase is 2.5 units i.e. tenfold that of the person with the largest increase in the group.
Purple-Bike
in
Advanced Prostate Cancer
3 years ago
Stimulants for ADT fatigue?
., Chahin, R. and Alibhai, S.M. (2015), Phase II, randomised, double‐blind, placebo‐controlled trial of methylphenidate for reduction of fatigue levels in patients with prostate cancer receiving
LHRH
‐
agonist
therapy.
., Chahin, R. and Alibhai, S.M. (2015), Phase II, randomised, double‐blind, placebo‐controlled trial of methylphenidate for reduction of fatigue levels in patients with prostate cancer receiving
LHRH
‐
agonist
therapy.
A0007720
in
Advanced Prostate Cancer
3 years ago
tE2 – History, Sourcing, and obstacles in the US
I’m writing this post with a preamble that these are my opinions, and I cannot prove any of them, nor am I trying to prove them. So, please read these conclusions with this information in mind. I believe that information about tE2 is difficult to uncover because in the US, the medical industrial complex
I’m writing this post with a preamble that these are my opinions, and I cannot prove any of them, nor am I trying to prove them. So, please read these conclusions with this information in mind. I believe that information about tE2 is difficult to uncover because in the US, the medical industrial complex
ragnar2020
in
Advanced Prostate Cancer
3 years ago
6-month Update: PSA down / Testosterone up
B) Change Leuprolide for any other
LHRH
agonist
like Triptorelin or Goserelin (this wouldnt be economically viable, since it has to be paid from our empty pocket because public system only have Leuprolide).
B) Change Leuprolide for any other
LHRH
agonist
like Triptorelin or Goserelin (this wouldnt be economically viable, since it has to be paid from our empty pocket because public system only have Leuprolide).
olloreda
in
Advanced Prostate Cancer
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
If T is above target, physicians should ensure adherence to ADT dosing schedules, prescribe a different formulation of
LHRH
agonist
/antagonist therapy or offer surgical castration.
If T is above target, physicians should ensure adherence to ADT dosing schedules, prescribe a different formulation of
LHRH
agonist
/antagonist therapy or offer surgical castration.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Metformin: Preliminary Results of Trial in Advanced Prostate Cancer (MANSMED)
Patients were randomized in a 1:1 fashion to receive standard of care with combined androgen blockade using
LHRH
agonist
and bicalutamide 50mg daily with or without metformin 850mg PO BID.
Patients were randomized in a 1:1 fashion to receive standard of care with combined androgen blockade using
LHRH
agonist
and bicalutamide 50mg daily with or without metformin 850mg PO BID.
noahware
in
Advanced Prostate Cancer
4 years ago
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