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XTANDI(Enzalutamide) Granted European Commission Approval for Use in Additional Recurrent Early Prostate Cancer Treatment Setting
high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation therapy Approval is based on results from the positive Phase 3 EMBARK study which showed XTANDI alone or in combination with
leuprolide
high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation therapy Approval is based on results from the positive Phase 3 EMBARK study which showed XTANDI alone or in combination with
leuprolide
Maxone73
in
Advanced Prostate Cancer
27 days ago
EMBARK Study: ADT vs Enzalutamide +/- ADT
Patients were randomly assigned, in a 1:1:1 ratio, to receive enzalutamide (160 mg) daily plus
leuprolide
every 12 weeks (combination group), placebo plus
leuprolide
(
leuprolide
-alone group), or enzalutamide monotherapy (monotherapy group).
Patients were randomly assigned, in a 1:1:1 ratio, to receive enzalutamide (160 mg) daily plus
leuprolide
every 12 weeks (combination group), placebo plus
leuprolide
(
leuprolide
-alone group), or enzalutamide monotherapy (monotherapy group).
MateoBeach
in
Advanced Prostate Cancer
7 months ago
EMBARK Study: Enzalutamide +/- ADT
Patients were randomly assigned, in a 1:1:1 ratio, to receive enzalutamide (160 mg) daily plus
leuprolide
every 12 weeks (combination group), placebo plus
leuprolide
(
leuprolide
-alone group), or enzalutamide monotherapy (monotherapy group).
Patients were randomly assigned, in a 1:1:1 ratio, to receive enzalutamide (160 mg) daily plus
leuprolide
every 12 weeks (combination group), placebo plus
leuprolide
(
leuprolide
-alone group), or enzalutamide monotherapy (monotherapy group).
MateoBeach
in
Fight Prostate Cancer
7 months ago
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Radiation?
just got my psa results after my first round of 4 months
leuprolide
and 3 months Zytiga and prednisone…..initially 18 now 0.04.
just got my psa results after my first round of 4 months
leuprolide
and 3 months Zytiga and prednisone…..initially 18 now 0.04.
Tommyj2
in
Advanced Prostate Cancer
4 months ago
Starting the journey Interested in comments Gleason 5+4 Met to Lymph and Maybe ribs
They say the treatment isn't much different, and are starting meds with 7 days of Bicalutamide, then a shot of
Leuprolide
every 6 months along with Abiraterone and Prednisone daily. Radiation IGBT to follow in 3 months.
They say the treatment isn't much different, and are starting meds with 7 days of Bicalutamide, then a shot of
Leuprolide
every 6 months along with Abiraterone and Prednisone daily. Radiation IGBT to follow in 3 months.
Saladman50
in
Advanced Prostate Cancer
26 days ago
My 6 Month Lupron cost
08/07/2023
Leuprolide
Acetate injection Total charge $33,685.45 Discount $31,927.45 Plan rate $1,758.00 Other insurance $0.00 KP paid $0.00 Not covered $0.00 Deductible $0.00 Copay / Coinsurance $351.60 Your share $351.60
08/07/2023
Leuprolide
Acetate injection Total charge $33,685.45 Discount $31,927.45 Plan rate $1,758.00 Other insurance $0.00 KP paid $0.00 Not covered $0.00 Deductible $0.00 Copay / Coinsurance $351.60 Your share $351.60
Hidden
in
Advanced Prostate Cancer
9 months ago
PSA rising on Triplet Therapy after <18m
He began triplet therapy (initially degarelix, then
leuprolide
+ abiraterone and prednisone) soon after. By September it had fallen to under 0.1 and then under 0.05 by the summer of 2023. Subsequent PET scans showed some bone mets had shrunk, others were unchanged.
He began triplet therapy (initially degarelix, then
leuprolide
+ abiraterone and prednisone) soon after. By September it had fallen to under 0.1 and then under 0.05 by the summer of 2023. Subsequent PET scans showed some bone mets had shrunk, others were unchanged.
nyc_son
in
Advanced Prostate Cancer
3 months ago
QOL: summer cruise on the coast of Maine
Tomorrow I start Degarelix injections once again after being on a three month
leuprolide
depo-formulation ,I am thankful for those sweet summer days, but I think it better to go back to a monthly injection and regular visits with my MO. And so my brothers my voyage continues
Tomorrow I start Degarelix injections once again after being on a three month
leuprolide
depo-formulation ,I am thankful for those sweet summer days, but I think it better to go back to a monthly injection and regular visits with my MO. And so my brothers my voyage continues
yardsailor
in
Advanced Prostate Cancer
8 months ago
Clinical Trial Considerations??
The ADT adds niraparib to the traditional abiraterone, prednisone, and
leuprolide
mix. Niraparib (a PARP inhibitor) was recently FDA approved for prostate cancer treatment, primarily for men with castration-resistant cancer. It’s been used with cervical and ovarian cancer.
The ADT adds niraparib to the traditional abiraterone, prednisone, and
leuprolide
mix. Niraparib (a PARP inhibitor) was recently FDA approved for prostate cancer treatment, primarily for men with castration-resistant cancer. It’s been used with cervical and ovarian cancer.
CubFan
in
Prostate Cancer Network
7 months ago
Bicalutamide 50 mg/ Leuprolide
Decided to start treatment today Bicalutamide followed by
Leuprolide
next week. Leaving on vacation next week for couple months in mountains hoping not to have many side affects.
Decided to start treatment today Bicalutamide followed by
Leuprolide
next week. Leaving on vacation next week for couple months in mountains hoping not to have many side affects.
Hobie14
in
Advanced Prostate Cancer
11 months ago
Xtandi monotherapy is very effective
This phase 3 randomized trial had three arms and compared in patients with high-risk biochemically recurrent prostate cancer: - enzalutamide plus
leuprolide
- enzalutamide monotherapy - placebo plus
leuprolide
The primary endpoint was metastasis-free survival (MFS).
This phase 3 randomized trial had three arms and compared in patients with high-risk biochemically recurrent prostate cancer: - enzalutamide plus
leuprolide
- enzalutamide monotherapy - placebo plus
leuprolide
The primary endpoint was metastasis-free survival (MFS).
GP24
in
Advanced Prostate Cancer
1 year ago
Enzalutamide plus leuprolide reduces risk of metastasis in nonmetastatic HSPC men-from Urology Times, 29 Apr 2023
The 3- and 5-year MFS rates for those treated with enzalutamide plus
leuprolide
were 92.9% and 87.3%, respectively, compared with 83.5% and 71.4% for those given
leuprolide
alone.
The 3- and 5-year MFS rates for those treated with enzalutamide plus
leuprolide
were 92.9% and 87.3%, respectively, compared with 83.5% and 71.4% for those given
leuprolide
alone.
Balsam01
in
Advanced Prostate Cancer
1 year ago
EMBARK trial results reported
[/i] https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-enzalutamide-plus-
leuprolide
[/i] https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-enzalutamide-plus-
leuprolide
GP24
in
Advanced Prostate Cancer
1 year ago
LEUPRORELIN ACETATE
Any information on results or side effects for this ADT
Any information on results or side effects for this ADT
Stevegr
in
Advanced Prostate Cancer
7 months ago
I wonder if anyone knows why or has experienced a rise on PSA level (from 70 to 274), 6 months after radiation therapy (VMAT x 26 sessions)?
Before and after radiation therapy, dad was taking Bicalutamide 50 mg and Alfuzosin50 mg together with a quarterly Leuprorelin injection. This month (October), after receiving his Leuprorelin injection, Urologist advised to stop taking Bicalutamide as it is no longer effective due to hormone resistance
Before and after radiation therapy, dad was taking Bicalutamide 50 mg and Alfuzosin50 mg together with a quarterly Leuprorelin injection. This month (October), after receiving his Leuprorelin injection, Urologist advised to stop taking Bicalutamide as it is no longer effective due to hormone resistance
Iloveyoudad
in
Advanced Prostate Cancer
7 months ago
Latest from PubMed
Impact of Concomitant Prostate Cancer Medications on Efficacy and Safety of Relugolix Versus
Leuprolide
in Men With Advanced Prostate Cancer. George DJ, Saad F, Cookson MS, Saltzstein DR, Tutrone R, Bossi A, Brown B, Selby B, Lu S, Buckley D, Tombal B, Shore ND.
Impact of Concomitant Prostate Cancer Medications on Efficacy and Safety of Relugolix Versus
Leuprolide
in Men With Advanced Prostate Cancer. George DJ, Saad F, Cookson MS, Saltzstein DR, Tutrone R, Bossi A, Brown B, Selby B, Lu S, Buckley D, Tombal B, Shore ND.
Magnus1964
in
Advanced Prostate Cancer
1 year ago
Acute manic and psychotic symptoms following subcutaneousleuprolide in a male patient without prior psychiatric history:A case report
Upon the recommendation of his physician, the patient received
leuprolide
45 mg subcutaneously approximately 2 months prior to this admission; this dose is intended to be administered once every 6 months. His past medical history was otherwise unremarkable.
Upon the recommendation of his physician, the patient received
leuprolide
45 mg subcutaneously approximately 2 months prior to this admission; this dose is intended to be administered once every 6 months. His past medical history was otherwise unremarkable.
Carlosbach
in
Advanced Prostate Cancer
1 year ago
Just joined the club no one wants to be a member of in April 2023 - can Gleason 9 be cured ?
I am now on Eligard (
leuprolide
injection) and taking daily 240 mg of Erleada (apalutamide). I am treating at a NCI CCC and the third largest cancer hospital in the country. I am on a much more aggressive treatment plan than the one the local urologists suggested.
I am now on Eligard (
leuprolide
injection) and taking daily 240 mg of Erleada (apalutamide). I am treating at a NCI CCC and the third largest cancer hospital in the country. I am on a much more aggressive treatment plan than the one the local urologists suggested.
68Guitar
in
Advanced Prostate Cancer
7 months ago
The Use of Low Dose Estradiol to Ameliorate the Effects of ADT on Bone Mass Density
It should be noted that abiraterone + prednisone, as a second line therapy, was initiated in August 2020, ~58 months after ADT with
leuprolide
was started.
It should be noted that abiraterone + prednisone, as a second line therapy, was initiated in August 2020, ~58 months after ADT with
leuprolide
was started.
PhilipSZacarias
in
Advanced Prostate Cancer
1 year ago
Bill Bixby's Battle with Prostate Cancer
Bill Bixby, an actor known for his "Incredible Hulk" films and many other achievements, died of prostate cancer November 21,1993, having learned that he had the disease in April of 1991. He died at age 59. Here's his biography: https://www.closerweekly.com/posts/bill-bixby-hulk-star-remembered-by-his-official-biographer
Bill Bixby, an actor known for his "Incredible Hulk" films and many other achievements, died of prostate cancer November 21,1993, having learned that he had the disease in April of 1991. He died at age 59. Here's his biography: https://www.closerweekly.com/posts/bill-bixby-hulk-star-remembered-by-his-official-biographer
NecessarilySo
in
Advanced Prostate Cancer
1 year ago
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