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Targeting cell death: helping push cancer cells over the edge
The BCL-2 family regulate one of the body’s apoptotic pathways. As scientists understand more about these proteins, they are able to push the boundaries of cancer research. The BCL-2 family is broadly divided into two types: pro-survival proteins, including BCL-2, BCL-XL, BCL-W and MCL-1, which help
The BCL-2 family regulate one of the body’s apoptotic pathways. As scientists understand more about these proteins, they are able to push the boundaries of cancer research. The BCL-2 family is broadly divided into two types: pro-survival proteins, including BCL-2, BCL-XL, BCL-W and MCL-1, which help
Jm954
Administrator
in
CLL Support
4 years ago
One-to-one buddy support
We have trained buddies to support those diagnosed with:
Acute myeloid
(AML)
Acute lymphoblastic
(ALL)
Acute promyelocytic
(APL)
Chronic lymphocytic
(CLL)
Chronic myeloid
(CML)
Chronic myelomonocytic
We have trained buddies to support those diagnosed with:
Acute myeloid
(AML)
Acute lymphoblastic
(ALL)
Acute promyelocytic
(APL)
Chronic lymphocytic
(CLL)
Chronic myeloid
(CML)
Chronic myelomonocytic
HAIRBEAR_UK
Administrator
in
Leukaemia CARE
4 years ago
Study finds targeting nearby ‘normal’ cells could improve survival rates
They found that when a stroma cell’s genes made it unable to produce this protein, it developed resistance to lymphoma and
leukaemia
.
They found that when a stroma cell’s genes made it unable to produce this protein, it developed resistance to lymphoma and
leukaemia
.
Jm954
Administrator
in
CLL Support
4 years ago
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High platelets essential thrombocytosis
So been to see haematologist today Pointless exercise- all bloods normal but jak2 mutation still outstanding. He said if its essential thrombocytosis I will need aspirin and not to worry? I honestly am so upset
So been to see haematologist today Pointless exercise- all bloods normal but jak2 mutation still outstanding. He said if its essential thrombocytosis I will need aspirin and not to worry? I honestly am so upset
Irishgal12
in
MPN Voice
4 years ago
FISH testing and chromosomes for dummies
I am betting most of us had a cll tabula rasa at diagnosis, that is, our knowledge of cll was a blank slate. When told I had cll, all I heard was the word "leukemia". Google became my best friend and worst enemy. One of the first things I learned was that cll was not as bad as some other leukemias.
I am betting most of us had a cll tabula rasa at diagnosis, that is, our knowledge of cll was a blank slate. When told I had cll, all I heard was the word "leukemia". Google became my best friend and worst enemy. One of the first things I learned was that cll was not as bad as some other leukemias.
cajunjeff
in
CLL Support
4 years ago
Email
Your GP and receptionist should be made aware that you have
leukaemia
and are immune compromised, so that your symptoms can be investigated immediately. The symptoms of the corona virus are shown below.
Your GP and receptionist should be made aware that you have
leukaemia
and are immune compromised, so that your symptoms can be investigated immediately. The symptoms of the corona virus are shown below.
TheFlyer
in
CLL Support
4 years ago
Why Is the Immunoglobulin Heavy Chain Gene Mutation Status a Prognostic Indicator in CLL? - Dr Keating
A complex but interesting read Acta Haematol August 2018;140:51–54 The immunoglobulin heavy chain gene (IgHV) mutation status correlates with the clinical outcome of patients with CLL treated with chemoimmunotherapy. Why the survival rate of patients with unmutated IgHV is worse than that of patients
A complex but interesting read Acta Haematol August 2018;140:51–54 The immunoglobulin heavy chain gene (IgHV) mutation status correlates with the clinical outcome of patients with CLL treated with chemoimmunotherapy. Why the survival rate of patients with unmutated IgHV is worse than that of patients
Jm954
Administrator
in
CLL Support
4 years ago
going downhill
My husband has CLL dx in 2013. Ok until this last year. Now has gone downhill. He is not to computer friendly so I am doing this. He was started on VENETOCLAX and is on week 3 of the ramping up. Extremely fatigued. Poor appetite. Sleeps a lot. The doc thinks this is a combo of the CLL and the s/e of
My husband has CLL dx in 2013. Ok until this last year. Now has gone downhill. He is not to computer friendly so I am doing this. He was started on VENETOCLAX and is on week 3 of the ramping up. Extremely fatigued. Poor appetite. Sleeps a lot. The doc thinks this is a combo of the CLL and the s/e of
Gogldn
in
CLL Support
4 years ago
New Need Advice please
Hello, I am new here and so confused. I saw a hematologist in October due to swollen lymph nodes and high eosinophils he ordered bone marrow biopsy. Which came back showing MPN he stated, but nothing to do but wait no further testing recommend. My grandfather had myelofibrosis. I am not comfortable just
Hello, I am new here and so confused. I saw a hematologist in October due to swollen lymph nodes and high eosinophils he ordered bone marrow biopsy. Which came back showing MPN he stated, but nothing to do but wait no further testing recommend. My grandfather had myelofibrosis. I am not comfortable just
chefwife8
in
MPN Voice
4 years ago
Winter blues
Hi I've got hypersensitivity pneumonitis with fibrosis. I've been diagnosed for 3 years now. But have suffered in the winter for a long time. Does anyone know of any tips to help me manage when I am outside? Almaz65
Hi I've got hypersensitivity pneumonitis with fibrosis. I've been diagnosed for 3 years now. But have suffered in the winter for a long time. Does anyone know of any tips to help me manage when I am outside? Almaz65
Almaz65
in
Lung Conditions Community Forum
4 years ago
Advice please....
It's been 3 weeks since my diagnosis for Hairy Cell
Leukaemia
and I'm slowly coming to terms with it, however I am confused. My consultant at the hospital has put me on 'Wait and Watch' but said I would be monitored regularly and would need regular blood tests and scans.
It's been 3 weeks since my diagnosis for Hairy Cell
Leukaemia
and I'm slowly coming to terms with it, however I am confused. My consultant at the hospital has put me on 'Wait and Watch' but said I would be monitored regularly and would need regular blood tests and scans.
TM1972
in
Leukaemia CARE
4 years ago
Remission
So the PETSCAN and the bone marrow biopsy say no leukemia or lymphoma for me. That means total remission but they still want me to have a transplant waiting for an appointment from MD Anderson in Texas.
So the PETSCAN and the bone marrow biopsy say no leukemia or lymphoma for me. That means total remission but they still want me to have a transplant waiting for an appointment from MD Anderson in Texas.
SwiftT
in
CLL Support
4 years ago
Hair transplant and CLL
Has anyone here with CLL had a hair transplant (after early stage diagnosis?) Is that safe or crazy? I'm relatively young to have it and I guess a bit vain but am not sure if the CLL makes no difference or the trauma encourages it.....
Has anyone here with CLL had a hair transplant (after early stage diagnosis?) Is that safe or crazy? I'm relatively young to have it and I guess a bit vain but am not sure if the CLL makes no difference or the trauma encourages it.....
Research123
in
CLL Support
4 years ago
CLL Horizons 2019 - Edinburgh 19-21 September - video of speaker sessions
This event was held during the international workshop on chronic lymphocytic
leukaemia
(CLL), to share latest clinical advances in medicine and care to inform advocacy initiatives.
This event was held during the international workshop on chronic lymphocytic
leukaemia
(CLL), to share latest clinical advances in medicine and care to inform advocacy initiatives.
HAIRBEAR_UK
Administrator
in
CLL Support
4 years ago
1 week update into Imbruvica
My first 7 days of Imbruvica 420 mg haven't been as bad as expected. No fatigue to speak of. The only side effects are temporary stomachs which I can remedy with yogurt or digestive enzymes, and temporary intestinal cramps.
My first 7 days of Imbruvica 420 mg haven't been as bad as expected. No fatigue to speak of. The only side effects are temporary stomachs which I can remedy with yogurt or digestive enzymes, and temporary intestinal cramps.
12Caine12
in
CLL Support
4 years ago
Need some info please.
Hi there, I am a 75 year old female. From Adelaide in South Australia. I have still managed to manage all my everyday life,drive and I volunteer 20 hours a week for a goodwill shop. I was diagnosed with cll just over 2 years ago. I saw a haematologist twice and put on watch and wait. I opted to see
Hi there, I am a 75 year old female. From Adelaide in South Australia. I have still managed to manage all my everyday life,drive and I volunteer 20 hours a week for a goodwill shop. I was diagnosed with cll just over 2 years ago. I saw a haematologist twice and put on watch and wait. I opted to see
JanEyre
in
CLL Support
4 years ago
Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell CLL
Chronic Lymphocytic
Leukaemia
(CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function.
Chronic Lymphocytic
Leukaemia
(CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function.
gardening-girl
in
CLL Support
4 years ago
SMC decision regarding Ruxolitinib (Jakavi) for PV patients in Scotland
Submissions and representation at the PACE meeting were also made by
Leukaemia
Care and Bloodwise. We would like to thank both organizations for their input and collaboration in this very important milestone for PV patients.
Submissions and representation at the PACE meeting were also made by
Leukaemia
Care and Bloodwise. We would like to thank both organizations for their input and collaboration in this very important milestone for PV patients.
Mazcd
MPNVoice
in
MPN Voice
4 years ago
Going down
I lost my Dad suddenly in April 19’ to a complication of
Leukaemia
when we thought he was recovering well and in the last few weeks my uncle died, unexpectedly on a flight home from his holiday. I don’t think that I have even started to grieve properly for Dad yet and now my Uncle going too.
I lost my Dad suddenly in April 19’ to a complication of
Leukaemia
when we thought he was recovering well and in the last few weeks my uncle died, unexpectedly on a flight home from his holiday. I don’t think that I have even started to grieve properly for Dad yet and now my Uncle going too.
mynameisbecki
in
Mental Health Support
4 years ago
HIV SCARE
Common causes include: * cancer treatment, like radiotherapy * anti-psychotic drugs * medication for an overactive thyroid * some cancers, like
leukaemia
* infections such as HIV or hepatitis * autoimmune disorders, like rheumatoid arthritis Now obviously because it says HIV I’m abit scared..
Common causes include: * cancer treatment, like radiotherapy * anti-psychotic drugs * medication for an overactive thyroid * some cancers, like
leukaemia
* infections such as HIV or hepatitis * autoimmune disorders, like rheumatoid arthritis Now obviously because it says HIV I’m abit scared..
Tmarecha1
in
BASHH
4 years ago
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