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Reflections from Cardiff, news of CLL research and the changing trials landscape
Hi everyone After reflecting on yesterday's Cardiff CLLSA patient meeting and the talks by leading UK clinical researchers and scientists. The developing new era of CLL medicine became real for me. Change is afoot, things are happening. There is good reason for the air of optimism
Hi everyone After reflecting on yesterday's Cardiff CLLSA patient meeting and the talks by leading UK clinical researchers and scientists. The developing new era of CLL medicine became real for me. Change is afoot, things are happening. There is good reason for the air of optimism
HAIRBEAR_UK
Administrator
in
CLL Support
11 years ago
Is Allopurinol not needed for continuing treatment with FCR if the WBC is 2.0?
keepfit123
in
CLL Support
11 years ago
Syk inhibitor... new target kinase... pre-clinical characteristics of P505-15
The selective Syk inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo, and augments the activity of
fludarabine
in chronic lymphocytic leukemia.
The selective Syk inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo, and augments the activity of
fludarabine
in chronic lymphocytic leukemia.
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
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Doctors should use different therapies when treating older and younger CLL patients
Rituximab combined with
fludarabine
, versus
fludarabine
alone, improves progression-free and overall survival in both younger and older patients.
Rituximab combined with
fludarabine
, versus
fludarabine
alone, improves progression-free and overall survival in both younger and older patients.
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
ASH 2012 Interview: Dr Jeff Sharman "Why New CLL Treatments Supersede FCR"
Dr Sharman's blog http://www.cll-nhl.com, is well worth keeping an eye on for pertinent but easily understandable articles on lymphomas, with CLL getting plenty of attention lately. In the video below, Andrew Schorr of Patient Power, asks Dr Sharman to discuss whether emerging therapies will replace
Dr Sharman's blog http://www.cll-nhl.com, is well worth keeping an eye on for pertinent but easily understandable articles on lymphomas, with CLL getting plenty of attention lately. In the video below, Andrew Schorr of Patient Power, asks Dr Sharman to discuss whether emerging therapies will replace
AussieNeil
Partner
in
CLL Support
11 years ago
Hi everyone , how far do you think we are away from not using FCR has the first line treatment , and drugs such as ibrutinib or cal - 101
I know some ibrutinib trials has began in the uk also consultants going through NICE to make this drug available to some patients Stewie Watch and wait Student nurse
I know some ibrutinib trials has began in the uk also consultants going through NICE to make this drug available to some patients Stewie Watch and wait Student nurse
stewie
in
CLL Support
11 years ago
Does anyone have strange feelings in their neck having had FCR? I finished my treatment in Oct and have started having an uncomfortable neck
Nicebaps
in
CLL Support
11 years ago
Acadesine for patients with relapsed/refractory (CLL). Like fludarabine but very different.
.,
fludarabine
). Of importance... Acadesine is not reliant on the p53 tumor suppressor or ataxia telangiectasia mutated (ATM) proteins to drive apoptosis, and hence, the absence/loss of function of these proteins in patients with CLL should not affect the activity of acadesine.
.,
fludarabine
). Of importance... Acadesine is not reliant on the p53 tumor suppressor or ataxia telangiectasia mutated (ATM) proteins to drive apoptosis, and hence, the absence/loss of function of these proteins in patients with CLL should not affect the activity of acadesine.
Cllcanada
Top Poster CURE Hero
in
CLL Support
11 years ago
Patient Power interviews Dr Michael Keating at ASH 2012. FCR and the transition to better, kinder treatments.
In this 6 minute interview by Andrew Schorr, Dr Michael Keating of MD Anderson, the father of FCR, acknowledges that while FCR has given a third of patients sustained, deep remissions for 10 years or more, it is not a gentle therapy. In this video, he discusses the exciting promise offered by small
In this 6 minute interview by Andrew Schorr, Dr Michael Keating of MD Anderson, the father of FCR, acknowledges that while FCR has given a third of patients sustained, deep remissions for 10 years or more, it is not a gentle therapy. In this video, he discusses the exciting promise offered by small
AussieNeil
Partner
in
CLL Support
11 years ago
Do you know about Fludarabine and the lifelong need for irradiated blood?
Unirradiated blood and blood products could be fatal to
fludarabine
treated CLL patients.
Unirradiated blood and blood products could be fatal to
fludarabine
treated CLL patients.
Cllcanada
Top Poster CURE Hero
in
CLL Support
12 years ago
What does it mean when platelets continue to decline while on FCR?
Have had two rounds of FCR so far.
Have had two rounds of FCR so far.
irish828
in
CLL Support
11 years ago
What size tablets are Fludarabine and Cyclophosphamide?
keepfit123
in
CLL Support
12 years ago
The Journey so far ...
I was given 6 cycles of FCR (
Fludarabine
, Cyclophosphamide and Rituximab) although the cycles were every 4 weeks it last lasted 8 months due to infections that I managed to get during the programme.
I was given 6 cycles of FCR (
Fludarabine
, Cyclophosphamide and Rituximab) although the cycles were every 4 weeks it last lasted 8 months due to infections that I managed to get during the programme.
Nicebaps
in
CLL Support
12 years ago
I'm new to the site! My story!
In 2005, I was very active running a dance club with my husband and friends, and also very worried about my Mum's health, when I discovered a pea-sized lump on my shoulder. I had been feeling tired but thought nothing of it. I would even slide down the stairs on my bottom rather than walk. After
In 2005, I was very active running a dance club with my husband and friends, and also very worried about my Mum's health, when I discovered a pea-sized lump on my shoulder. I had been feeling tired but thought nothing of it. I would even slide down the stairs on my bottom rather than walk. After
Marisa
in
CLL Support
12 years ago
Tests to judge if need more FCR
Hi. Thank you for setting up this site; I am sure it will be a great help to us all. I have had CLL for a number of years, on reflection probably 7 years at least. I started FCR in August and have had 3 monthly sessions to date. I have an appoint beginning of December to ascertain if more FCR sessions
Hi. Thank you for setting up this site; I am sure it will be a great help to us all. I have had CLL for a number of years, on reflection probably 7 years at least. I started FCR in August and have had 3 monthly sessions to date. I have an appoint beginning of December to ascertain if more FCR sessions
Jupiter
in
CLL Support
12 years ago
My experience so far
Hi, I registered yesterday and have read some of the blog entries and having found value felt I should put my experience down in the blog in the hope that it helps someone. So, had a 'well man' type checkup with my local health worker back in April 2012, St George's day to be precise. Was told I
Hi, I registered yesterday and have read some of the blog entries and having found value felt I should put my experience down in the blog in the hope that it helps someone. So, had a 'well man' type checkup with my local health worker back in April 2012, St George's day to be precise. Was told I
Oleboyredw-uk
in
CLL Support
12 years ago
My 3 years of living with CLL
I was diagnosed in July 2009 following a routine blood test. It later transpired that it had shown up in a previous blood test 18 months earlier but had not been picked up! My GP said that I had a raised white cell count and I then received an appointment to see a Consultant two weeks later so I knew
I was diagnosed in July 2009 following a routine blood test. It later transpired that it had shown up in a previous blood test 18 months earlier but had not been picked up! My GP said that I had a raised white cell count and I then received an appointment to see a Consultant two weeks later so I knew
arthur123
in
CLL Support
12 years ago
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