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Low-T is associated with worse Prostate Cancer Specific Mortality probability after 6 months of ADT: Part III
Here are comparisons of the
Prostate Cancer Specific Mortality (PCSM) probability (%
) for two different testosterone levels (
Low-T and Normal-T
) and four different
Times After PSA Failure
from the Kaplan-Meier plot previously posted. (Atkins 2018). The median testosterone for
Here are comparisons of the
Prostate Cancer Specific Mortality (PCSM) probability (%
) for two different testosterone levels (
Low-T and Normal-T
) and four different
Times After PSA Failure
from the Kaplan-Meier plot previously posted. (Atkins 2018). The median testosterone for
janebob99
in
Prostate Cancer Network
3 months ago
Low-T is associated with worse Prostate Cancer Specific Mortality probability after 6 months of ADT: Part II
Here are comparisons of the Prostate Cancer Specific Mortality (PCSM) probability (%) for two different testosterone levels (Low-T and Normal-T)and three different Times After PSA Failure from Atkins (2018). he median testosterone for the Low-T group is T = 162 ng/dL [120-236], and I assumed an average
Here are comparisons of the Prostate Cancer Specific Mortality (PCSM) probability (%) for two different testosterone levels (Low-T and Normal-T)and three different Times After PSA Failure from Atkins (2018). he median testosterone for the Low-T group is T = 162 ng/dL [120-236], and I assumed an average
janebob99
in
Prostate Cancer Network
3 months ago
Updating my husband's journey, hoping it helps others - any words of encouragement are welcome, but please only positive comments
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
The first part is in my profile. It makes me feel vulnerable to share, but we have benefited enormously from reading others' stories, so I'm sharing. UPDATE: 8/18/21 PSA =0.45 9/6/21 last dose Orgovyx 9/7/21 First Eligard 3 month shot 9/17/21 PSA =0.78 10/18/21 PSA =1.28 Nov not tested 12
SuppWife
in
Advanced Prostate Cancer
3 months ago
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Magnesium, zinc and calcium
Nearly a year after ADT and all clear with testosterone recovering well. Been advised by a fellow runner to try a supplement of magnesium, zinc and calcium. The Onco has no objections. Are there reasons no too? Thank you.
Nearly a year after ADT and all clear with testosterone recovering well. Been advised by a fellow runner to try a supplement of magnesium, zinc and calcium. The Onco has no objections. Are there reasons no too? Thank you.
Runner1957
in
Prostate Cancer Network
3 months ago
WORRIED ABOUT REOCCURRENCE???
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
Worried....
Stopped IMRT 1 year ago and stopped adt (4 mos) 9 months ago...
9/23/23 Blood Test PSA .1 --- PSA FREE undetectable and Testosterone was 98
3/4/24 Blood Test PSA .2 ----Psa Free Undetectable and Testosterone not in yet.
I am concerned about the increase
JWS13
in
Advanced Prostate Cancer
3 months ago
Testosterone volatility
My testosterone was measured @ 490 in 2014 when I was DX with PCa Gleason 6, it was measured again in 2016 at 463. It was not measured again until after I started on ADT and it has been >7 ever since. Is there a way for me to extrapolate what it would have been in 2021 when I was DX with Gleason
My testosterone was measured @ 490 in 2014 when I was DX with PCa Gleason 6, it was measured again in 2016 at 463. It was not measured again until after I started on ADT and it has been >7 ever since. Is there a way for me to extrapolate what it would have been in 2021 when I was DX with Gleason
Scout4answers
in
Prostate Cancer Network
3 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
3 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
3 months ago
Hypo, Hashi's, Menopause & Testosterone
My last sex hormone blood test showed my testosterone at [u]
1.91!
[/u]
(range of 0.10-1.42) This concerns my Endo doc who has been amazing treating my thyroid issues, but has now informed me that AFTER
age 60
you shouldn't BEGIN hrt. šŖ So, that's out of the question for me since
My last sex hormone blood test showed my testosterone at [u]
1.91!
[/u]
(range of 0.10-1.42) This concerns my Endo doc who has been amazing treating my thyroid issues, but has now informed me that AFTER
age 60
you shouldn't BEGIN hrt. šŖ So, that's out of the question for me since
wavedancers
in
Thyroid UK
3 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
janebob99
in
Prostate Cancer Network
3 months ago
Low Testosterone reduces Survival by a huge amount.
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
janebob99
in
Prostate Cancer Network
3 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
3 months ago
PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
3 months ago
Medichecks help!
So Iām no not the best with maths and need help as Googleās confusing me even more! I ordered bloods through medichecks for DHEAs and testosterone as recommended on here and in the book āit starts with the eggā I waited a week and my lab results are inā¦ Great- or so I thought! Medichecks have
So Iām no not the best with maths and need help as Googleās confusing me even more! I ordered bloods through medichecks for DHEAs and testosterone as recommended on here and in the book āit starts with the eggā I waited a week and my lab results are inā¦ Great- or so I thought! Medichecks have
Eat-sleep-ivf-repeat
in
Fertility Network UK
3 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
3 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
3 months ago
Tuff Nutt is back with lots of questions!
In late November, 2023, I made two trips to ER for low BP and extreme chest pain in the same week. While in the hospital the second visit, my pre ER sore throat symptoms developed into something called HPIV-3. My first evening after being discharged, I developed uncontrollable coughing. This continued
In late November, 2023, I made two trips to ER for low BP and extreme chest pain in the same week. While in the hospital the second visit, my pre ER sore throat symptoms developed into something called HPIV-3. My first evening after being discharged, I developed uncontrollable coughing. This continued
TuffNuttoCrack
in
Advanced Prostate Cancer
3 months ago
High Testosterone Level Why?
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
Taffypaul
in
British Liver Trust
3 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
3 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
3 months ago
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