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What I learned from today's conference call...
Already approved:
enzalutamide
and apalutamide. New this year: darolutamide, an androgen receptor signaling inhibitor. Very positive results are being seen, better tolerated side effects, and a good safety profile. So, how to decide what to do?
Already approved:
enzalutamide
and apalutamide. New this year: darolutamide, an androgen receptor signaling inhibitor. Very positive results are being seen, better tolerated side effects, and a good safety profile. So, how to decide what to do?
tallguy2
in
Advanced Prostate Cancer
5 years ago
Pembrolizumab in Patients With Heavily Treated Metastatic Castration-Resistant Prostate Cancer
Despite prior progression on
enzalutamide
, 48% (23/48) of men were treated with concurrent
enzalutamide
.
Despite prior progression on
enzalutamide
, 48% (23/48) of men were treated with concurrent
enzalutamide
.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Denied for Vision Trial
While we were waiting for all the tests, his PSA went up to 530.62 so the doctor prescribed him Xtandi (
enzalutamide
) . It seems like he has more energy now. But I'm really scared how long it will last..... Will you please let me know what option will we have after Xtandi fail on him?
While we were waiting for all the tests, his PSA went up to 530.62 so the doctor prescribed him Xtandi (
enzalutamide
) . It seems like he has more energy now. But I'm really scared how long it will last..... Will you please let me know what option will we have after Xtandi fail on him?
Muzpapa
in
Advanced Prostate Cancer
5 years ago
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Radium-223 in Clinical Practice. Video
The PEACE III trial [[i]A Randomized Multicenter Phase III Trial Comparing
Enzalutamide
vs. a Combination of Ra223 and
Enzalutamide
in Asymptomatic or Mildly Symptomatic Castration Resistant Prostate Cancer Patients Metastatic to Bone[/i]] is mentioned.
The PEACE III trial [[i]A Randomized Multicenter Phase III Trial Comparing
Enzalutamide
vs. a Combination of Ra223 and
Enzalutamide
in Asymptomatic or Mildly Symptomatic Castration Resistant Prostate Cancer Patients Metastatic to Bone[/i]] is mentioned.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Enzalutamide working for my dad
We basically came to the conclusion for him to go on
Enzalutamide
since he has HTN and severe white coat syndrome! 3 weeks on
Enzalutamide
PSA dropped like a stone to 1.8!
We basically came to the conclusion for him to go on
Enzalutamide
since he has HTN and severe white coat syndrome! 3 weeks on
Enzalutamide
PSA dropped like a stone to 1.8!
fmoser
in
Advanced Prostate Cancer
5 years ago
Enzalutamide and docetaxel together?
Just wondering if anyone out there has done these two treatments together? And if so, what were the side effects and did you have any favorable results? Thanks much!!
Just wondering if anyone out there has done these two treatments together? And if so, what were the side effects and did you have any favorable results? Thanks much!!
MeliaQuinn
in
Advanced Prostate Cancer
5 years ago
Xtandi cost
My MO wants to Rx Xtandi (
Enzalutamide
). My part D Medicare supplement says it will cost $2400 the first month, and $600+ every month thereafter. I still work and have an income, but that cost is shocking. I would like to hear about financial assistance others have received in my situation.
My MO wants to Rx Xtandi (
Enzalutamide
). My part D Medicare supplement says it will cost $2400 the first month, and $600+ every month thereafter. I still work and have an income, but that cost is shocking. I would like to hear about financial assistance others have received in my situation.
xpbdb
in
Advanced Prostate Cancer
5 years ago
Enzalutamide With Standard Therapy in Metastatic Prostate Cancer
The
enzalutamide
group had more frequent treatment discontinuation due to adverse events than the standard-care group. Seizures occurred in 7 patients in the
enzalutamide
group (1%) and in no patients in the standard-care group.
The
enzalutamide
group had more frequent treatment discontinuation due to adverse events than the standard-care group. Seizures occurred in 7 patients in the
enzalutamide
group (1%) and in no patients in the standard-care group.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Enzalutamide With Standard Therapy in Metastatic Prostate Cancer - The New England Journal of Medicine
Journal Scan / Research · July 08, 2019 The authors concluded that
enzalutamide
in combination with androgen-deprivation therapy (ADT) is superior to ADT plus standard antiandrogen therapy and leads to an improvement in overall survival.
Journal Scan / Research · July 08, 2019 The authors concluded that
enzalutamide
in combination with androgen-deprivation therapy (ADT) is superior to ADT plus standard antiandrogen therapy and leads to an improvement in overall survival.
GranPaSmurf
in
Advanced Prostate Cancer
5 years ago
Next Step
He has castration-resistant prostate cancer with progression despite abiraterone,
enzalutamide
, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 4 of 6 infusions thus far.
He has castration-resistant prostate cancer with progression despite abiraterone,
enzalutamide
, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 4 of 6 infusions thus far.
Amandaslp78
in
Advanced Prostate Cancer
5 years ago
"Early initiation of Lu-177 PSMA radioligand therapy prolongs overall survival in metastatic prostate cancer"
Addition of Abiraterone or
Enzalutamide
provided a significant prolongation of survival (40 months, p<0.05). On the other hand, prior surgical or radiation treatment of primary tumor had no significant effect on the OS (30 months, p>0.05).
Addition of Abiraterone or
Enzalutamide
provided a significant prolongation of survival (40 months, p<0.05). On the other hand, prior surgical or radiation treatment of primary tumor had no significant effect on the OS (30 months, p>0.05).
tango65
in
Advanced Prostate Cancer
5 years ago
Advice needed please.
We are scheduled to see Dr Nick Plowman on Harley Street (He was strongly recommended by Dr Khoo at the Royal Marsden) My Father has never had radiation, chemo, xandti,
enzalutamide
, denosumab etc. What other treatments are viable at this stage?
We are scheduled to see Dr Nick Plowman on Harley Street (He was strongly recommended by Dr Khoo at the Royal Marsden) My Father has never had radiation, chemo, xandti,
enzalutamide
, denosumab etc. What other treatments are viable at this stage?
taylor123
in
Advanced Prostate Cancer
5 years ago
Doctors Who Are willing to Supervise Bipolar Androgen Therapy (BAT)
Denmeade† Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on
enzalutamide
: an open-label, phase 2, multicohort study https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30906-3/fulltext
Benjamin A Teply, MD
Hao
Denmeade† Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on
enzalutamide
: an open-label, phase 2, multicohort study https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30906-3/fulltext
Benjamin A Teply, MD
Hao
cesanon
in
Advanced Prostate Cancer
5 years ago
Flare in Prostate-specific Membrane Antigen PET Tracer Uptake with Initiation of Androgen Pathway Blockade in Metastatic Prostate Cancer.
The study confirms what it has been posted here by GP24 and others that ADT and
Enzalutamide
may increase the tracer uptake by the cancer cells. The uptake flare in this situation is not an indication of disease progression.
The study confirms what it has been posted here by GP24 and others that ADT and
Enzalutamide
may increase the tracer uptake by the cancer cells. The uptake flare in this situation is not an indication of disease progression.
tango65
in
Advanced Prostate Cancer
5 years ago
A Phase III Trial of Enzalutamide Versus Enzalutamide, Abiraterone and Prednisone for Metastatic Castration Resistant Prostate Cancer.
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112895-asco-2019-alliance-a031201-a-phase-iii-trial-of-
enzalutamide
-versus-
enzalutamide
-abiraterone-and-prednisone-for-metastatic-castration-resistant-prostate-cancer.html?
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112895-asco-2019-alliance-a031201-a-phase-iii-trial-of-
enzalutamide
-versus-
enzalutamide
-abiraterone-and-prednisone-for-metastatic-castration-resistant-prostate-cancer.html?
tango65
in
Advanced Prostate Cancer
5 years ago
Both apalutamide and enzalutamide succeed for metastatic hormone-sensitive prostate cancer (mHSPC) - enzalutamide not for high volume mets
However,
enzalutamide
was compared to antiandrogen (e.g., Casodex) +ADT, while apalutamide only had to beat ADT alone. More details here: https://pcnrv.blogspot.com/2019/05/two-new-advanced-hormonal-agents.html
However,
enzalutamide
was compared to antiandrogen (e.g., Casodex) +ADT, while apalutamide only had to beat ADT alone. More details here: https://pcnrv.blogspot.com/2019/05/two-new-advanced-hormonal-agents.html
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
Clinical Implications of New Data on Apalutamide + ADT in Castrate-Sensitive Prostate Cancer
So, I would like to make it very clear that this drug has not been compared with
enzalutamide
in a, you know, in a randomized setting.
So, I would like to make it very clear that this drug has not been compared with
enzalutamide
in a, you know, in a randomized setting.
Balsam01
in
Advanced Prostate Cancer
5 years ago
ASCO 2019 Abstracts.
Dose finding in combination (CCS1477 + abiraterone; CCS1477 +
enzalutamide
) will be open once monotherapy dose escalation completes.
Dose finding in combination (CCS1477 + abiraterone; CCS1477 +
enzalutamide
) will be open once monotherapy dose escalation completes.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Xtandi or Zytiga or Yonsa? Pros, Cons, Side Effects? What about Erleada?
What are the pros and cons of Xtandi (
enzalutamide
) and Zytiga (abiraterone acetate) and Yonsa another formulation of abiraterone acetate? Particularly regarding side effects. It seems the docs never do a good job of explaining side effects, until they are upon you.
What are the pros and cons of Xtandi (
enzalutamide
) and Zytiga (abiraterone acetate) and Yonsa another formulation of abiraterone acetate? Particularly regarding side effects. It seems the docs never do a good job of explaining side effects, until they are upon you.
cesanon
in
Advanced Prostate Cancer
5 years ago
Anxiety after coming off Enzalutamide
Anyone experienced the same post-
Enzalutamide
. Any/all Help appreciated.
Anyone experienced the same post-
Enzalutamide
. Any/all Help appreciated.
beatPC
in
Advanced Prostate Cancer
5 years ago
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